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Mesenchymal Stem Cells-Derived Exosomes for Wound Regeneration

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Cell Biology and Translational Medicine, Volume 4

Part of the book series: Advances in Experimental Medicine and Biology ((CBTMED,volume 1119))

Abstract

Wound healing is a complex process with the considerable burden on healthcare system. There are several cellular therapy methods that have been introduced to treat different types of wounds. Despite the advantages of cellular therapy, it is needed to overcome different limitations of this method such as; tumorigenicity and immune rejection. Accordingly, scientists have suggested cell-based vesicles and exosomes. Exosomes can promote proliferation, migration, and angiogenesis process in the wound environment. They have also some advantages such as the potential for drug and gene delivery, easy to storage, and stability in the body. These advantages make them as a novel approach in regenerative medicine without the limitations of cellular therapy. In this review, the authors emphasize on biological properties of MSC-exosomes and their therapeutic effects as a new strategy for wound regeneration.

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Abbreviations

ANGPT1:

Angiopoietin 1

ASCs:

Adipose-derived stem cells

BBB:

Blood-Brain Barrier

BM-MSCs:

Bone marrow-derived mesenchymal stem cells

CHA:

Composite collagen–hydroxyapatite

ECM:

Extra-cellular matrix

DFU:

Diabetic foot ulcers

EGF:

Epidermal growth factor

EVs:

Extra-cellular vesicles

FDA:

Food and Drug Administration

FGF 2:

Fibroblast growth factor 2

IGF-1:

Insulin growth factor 1

IL-1:

Interlukin 1

IL-6:

Interlukin 6

iPS:

Induced pluripotent stem cells

MSCs:

Mesenchymal stem cells

PDGF:

Platelet-derived growth factor

STAT3:

Signal transducer and activator of transcription 3

TGF-β1:

Transforming growth factor beta 1

TNF-α:

Tumor necrosis factor-alpha

UCB-MSCs:

Umbilical cord blood mesenchymal stem cells

VEGF:

Vascular endothelial growth factor

MSC Exo:

Mesenchymal stem cells-derived exosomes

HGF:

Hepatocyte growth factor

IGF-1:

Insulin-like growth factor 1

SDF-1:

Stromal cell-derived factor 1

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Acknowledgement

The authors would like to acknowledge Dr. Mohsen khorshidi, Firooze Hajipour, Rasta Arjmand, and Maryam Afshari for their kind support.

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Authors and Affiliations

  1. Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran

    Parisa Goodarzi & Fereshteh Mohamadi-Jahani

  2. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Bagher Larijani

  3. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Sepideh Alavi-Moghadam, Akram Tayanloo-Beik, Negar Ranjbaran & Babak Arjmand

  4. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Moloud Payab

  5. Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Khadijeh Falahzadeh, Maryamsadat Mousavi & Babak Arjmand

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  1. Parisa Goodarzi
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  2. Bagher Larijani
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Correspondence to Babak Arjmand .

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  1. Ottawa Hospital Research Institute, Ottawa, ON, Canada

    Kursad Turksen

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Goodarzi, P. et al. (2018). Mesenchymal Stem Cells-Derived Exosomes for Wound Regeneration. In: Turksen, K. (eds) Cell Biology and Translational Medicine, Volume 4. Advances in Experimental Medicine and Biology(), vol 1119. Springer, Cham. https://doi.org/10.1007/5584_2018_251

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