Abstract
Non-small cell lung cancer (NSCLC) is a serious health problem. Identifying factors affecting quality of life (QoL) may help modify risk factors and improve survival. The study included 180 patients treated for NSCLC in the Lower Silesian Center of Lung Diseases between January and December 2015. QoL was assessed with QLQ-C30 and QLQ-LC13 scales. General physical functioning was measured with the ECOG Performance Status scale. The clinical and sociodemographic data were retrieved from medical records. The influence of clinical and sociodemographic factors on QoL was examined. NSCLC reduced the global QoL (47.1 ± 23.4) and emotional functioning (57.8 ± 28.8); cognitive functioning was affected in least (76.0 ± 21.0). The patients reported fatigue (42.2 ± 26.2), sleep problems (42.0 ± 30.8), cough (49.8 ± 24.0), and taking analgesics (50.3 ± 37.1) as the most limiting factors. The worsening of a health condition expressed by the length of malignant disease; the presence of comorbidities, metastases, the cluster of symptoms, worse spirometric indices, and living alone had a negative influence on QoL. In conclusion, patients with NSCLC experience reduced QoL and emotional functioning. Proper treatment of comorbidities and symptom management may improve QoL in these patients.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, Filiberti A, Flechtner H, Fleischman SB, de Haes JC, Kaasa S, Klee M, Osoba D, Razavi D, Rofe PB, Schraub S, Sneeuw K, Sullivan M, Takeda F (1993) The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85(5):365–376
Arraras JI, Hernandez B, Martinez M, Cambra C, Rico M, Illarramendi JJ, Viudez A, Ibanez B, Zarandona U, Martinez E, Vera R (2016) Quality of life in Spanish advanced non-small-cell lung cancer patients: determinants of global QL and survival analyses. SpringerPlus 5:836
Bendixen M, Jorgensen OD, Kronborg C, Andersen C, Licht PB (2016) Postoperative pain and quality of life after lobectomy via video-assisted thoracoscopic surgery or anterolateral thoracotomy for early stage lung cancer: a randomised controlled trial. Lancet Oncol 17(6):836–844
Bergman B, Aaronson NK, Ahmedzai S, Kaasa S, Sullivan M (1994) The EORTC QLQ-LC13: a modular supplement to the EORTC Core Quality of Life Questionnaire (QLQ-C30) for use in lung cancer clinical trials. EORTC Study Group on Quality of Life. Eur J Cancer 30A(5):635–642
Braun DP, Gupta D, Staren ED (2011) Quality of life assessment as a predictor of survival in non-small cell lung cancer. BMC Cancer 11:353
Brown DJ, McMillan DC, Milroy R (2005) The correlation between fatigue, physical function, the systemic inflammatory response, and psychological distress in patients with advanced lung cancer. Cancer 103(2):377–382
Corre R, Greillier L, Le Caer H, Audigier-Valette C, Baize N, Berard H, Falchero L, Monnet I, Dansin E, Vergnenegre A, Marcq M, Decroisette C, Auliac JB, Bota S, Lamy R, Massuti B, Dujon C, Perol M, Daures JP, Descourt R, Lena H, Plassot C, Chouaid C (2016) Use of a comprehensive geriatric assessment for the management of elderly patients with advanced non-small-cell lung cancer: the Phase III Randomized ESOGIA-GFPC-GECP 08-02 Study. J Clin Oncol 34(13):1476–1483
de Oliveira PI, Pereira CA, Belasco AG, Bettencourt AR (2013) Comparison of the quality of life among persons with lung cancer, before and after the chemotherapy treatment. Rev Lat Am Enfermagem 21:787–794
Dela Cruz CS, Tanoue LT, Matthay RA (2011) Lung cancer: epidemiology, etiology, and prevention. Clin Chest Med 32(4):605–644
Didkowska J, Wojciechowska U, Manczuk M, Lobaszewski J (2016) Lung cancer epidemiology: contemporary and future challenges worldwide. Ann Transl Med 4:150
Griebsch I, Palmer M, Fayers PM, Ellis S (2014) Is progression-free survival associated with a better health-related quality of life in patients with lung cancer? Evidence from two randomised trials with afatinib. BMJ Open 4:e005762
Gupta D, Braun DP, Staren ED (2012) Association between changes in quality of life scores and survival in non-small cell lung cancer patients. Eur J Cancer Care (Engl) 21(5):614–622
Henoch I, Bergman B, Gustafsson M, Gaston-Johansson F, Danielson E (2007) The impact of symptoms, coping capacity, and social support on quality of life experience over time in patients with lung cancer. J Pain Symptom Manag 34(4):370–379
Larsson M, Ljung L, Johansson BB (2012) Health-related quality of life in advanced non-small cell lung cancer: correlates and comparisons to normative data. Eur J Cancer Care (Engl) 21:642–649
Leduc C, Quoix E (2016) Is there really a role for the comprehensive geriatric assessment in metastatic non-small cell lung cancer? Transl Cancer Res 5(Suppl 1):S44–S46
Li TC, Li CI, Tseng CH, Lin KS, Yang SY, Chen CY, Hsia TC, Lee YD, Lin CC (2012) Quality of life predicts survival in patients with non-small cell lung cancer. BMC Public Health 12:790
Li XH, Zhu JL, Hong C, Zeng L, Deng LM, Jin LY (2013) Effects of systematic rehabilitation programs on quality of life in patients undergoing lung resection. Mol Clin Oncol 1(1):200–208
Maione P, Perrone F, Gallo C, Manzione L, Piantedosi F, Barbera S, Cigolari S, Rosetti F, Piazza E, Robbiati SF, Bartetto O, Novello S, Migliorino MR (2005) Pretreatment quality of life and functional status assessment significantly predict survival of elderly patients with advanced non-small-cell lung cancer receiving chemotherapy: a prognostic analysis of the multicenter Italian lung cancer in the elderly study. J Clin Oncol 23(28):6865–6872
Montazeri A, Milroy R, Hole D, McEwen J, Gillis CR (2003) How quality of life data contribute to our understanding of cancer patients' experiences? A study of patients with lung cancer. Qual Life Res 12(2):157–166
Ngeow J, Leong SS, Gao F, Toh CK, Lim WT, Tan EH, Poon D (2010) Impact of comorbidities on clinical outcomes in non-small cell lung cancer patients who are elderly and/or have poor performance status. Crit Rev Oncol Hematol 76(1):53–60
Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET, Carbone PP (1982) Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 5:649–655
Rauma V, Sintonen H, Rasanen JV, Salo JA, Ilonen IK (2015) Long-term lung cancer survivors have permanently decreased quality of life after surgery. Clin Lung Cancer 16(1):40–45
Rauma V, Salo J, Sintonen H, Rasanen J, Ilonen I (2016) Patient features predicting long-term survival and health-related quality of life after radical surgery for non-small cell lung cancer. Thorac Cancer 7(3):333–339
Ridge CA, McErlean AM, Ginsberg MS (2013) Epidemiology of lung cancer. Semin Interv Radiol 30(2):93–98
Scott NW, Fayers PM, Aaronson NK, Bottoley A, de Greaff A, Groenvold M, Gundy C, Koller M, Pettersen MA, Sprangers MA (2008) EORTC QLQ-C30 reference values. https://groups.eortc.be/qol/sites/default/files/img/newsletter/reference_values_manual2008.pdf. Accessed on 27 Sept 2016
Tomaszewski KA, Puskulluoglu M, Biesiada K, Bochenek J, Nieckula J, Krzemieniecki K (2013) Validation of the Polish version of the eortc QLQ-C30 and the QLQ-OG25 for the assessment of health-related quality of life in patients with esophagi-gastric cancer. J Psychosoc Oncol 31(2):191–203
Ubels RJ, Mokhles S, Andrinopoulou ER, Braat C, van der Voort van Zyp NC, Aluwini S, Aerts JG, Nuyttens JJ (2015) Quality of life during 5 years after stereotactic radiotherapy in stage I non-small cell lung cancer. Radiat Oncol 10:98
Wang JW, Gong XH, Ding N, Chen XF, Sun L, Tang Z, Yu DH, Yuan ZP, Wang XD, Yu JM (2015) The influence of comorbid chronic diseases and physical activity on quality of life in lung cancer survivors. Support Care Cancer 23(5):1383–1389
Yun YH, Kim YA, Sim JA, Shin AS, Chang YJ, Lee J, Kim MS, Shim YM, Zo JL (2016) Prognostic value of quality of life score in disease-free survivors of surgically-treated lung cancer. BMC Cancer 16:505
Zikos E, Ghislain I, Coens C, Ediebah DE, Sloan E, Quinten C, Koller M, van Meerbeeck JP, Flechtner HH, Stupp R, Pallis A, Czimbalmos A, Sprangers MA, Bottomley A (2014) Health-related quality of life in small-cell lung cancer: a systematic review on reporting of methods and clinical issues in randomised controlled trials. Lancet Oncol 15(2):e78–e89
Conflict of Interests
The authors declare no conflicts of interest in relation to this article.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Chabowski, M., Polański, J., Mazur, G., Janczak, D., Rosińczuk, J. (2017). Sociodemographic and Clinical Determinants of Quality of Life of Patients with Non-small Cell Lung Cancer. In: Pokorski, M. (eds) Clinical Management of Pulmonary Disorders and Diseases. Advances in Experimental Medicine and Biology(), vol 1022. Springer, Cham. https://doi.org/10.1007/5584_2017_36
Download citation
DOI: https://doi.org/10.1007/5584_2017_36
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-69544-0
Online ISBN: 978-3-319-69545-7
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)