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Hyaluronidase and Chondroitinase

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Protein Reviews

Part of the book series: Advances in Experimental Medicine and Biology ((PROTRE,volume 925))

Abstract

Glycosaminoglycans (GAGs) are important constituents of the extracellular matrix that make significant contributions to biological processes and have been implicated in a wide variety of diseases. GAG-degrading enzymes with different activities have been found in various animals and microorganisms, and they play an irreplaceable role in the structure and function studies of GAGs. As two kind of important GAG-degrading enzymes, hyaluronidase (HAase) and chondroitinase (CSase) have been widely studied and increasing evidence has shown that, in most cases, their substrate specificities overlap and thus the “HAase” or “CSase” terms may be improper or even misnomers. Different from previous reviews, this article combines HAase and CSase together to discuss the traditional classification, substrate specificity, degradation pattern, new resources and naming of these enzymes.

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Abbreviations

GAG:

glycosaminoglycan

CS:

chondroitin sulfate

DS:

dermatan sulfate

HA:

hyaluronic acid

Hep:

heparin

HS:

heparan sulfate

GlcUA:

D-glucuronic acid

IdoUA:

L-iduronic acid

HexUA:

hexuronic acid

CSase:

chondroitinase

HAase:

hyaluronidase

GalNAc:

N-acetyl-D-galactosamine

GlcNAc:

N-acetyl-D-glucosamine

HexUA:

hexuronic acid

HexN:

hexosamine

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Acknowledgment

This work was financially supported by the National Natural Science Foundation of China (No. 31570071), the Major State Basic Research Development Program of China (No. 2012CB822102), and the Shenzhen strategic emerging industry development special funds (JCYJ20140418115815063).

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Authors and Affiliations

  1. National Glycoengineering Research Center, Shandong University, 27 S. Shanda Road, Jinan, 250100, China

    Wenshuang Wang & Fuchuan Li

  2. Shenzhen Research Institute of Shandong University, Rm A301, Virtual University Park, Nanshan, Shenzhen, 518057, China

    Wenshuang Wang & Fuchuan Li

  3. School of Foreign Languages, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai, 200093, China

    Junhong Wang

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  1. Wenshuang Wang
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Correspondence to Fuchuan Li .

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  1. Biochem and Mol Biol, Baylor College of Medicine, Houston, Texas, USA

    M. Zouhair Atassi

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Wang, W., Wang, J., Li, F. (2016). Hyaluronidase and Chondroitinase. In: Atassi, M. (eds) Protein Reviews. Advances in Experimental Medicine and Biology(), vol 925. Springer, Singapore. https://doi.org/10.1007/5584_2016_54

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