Abstract
The objective of this study was to investigate the relationship between smoking history expressed by pack-years, metabolic and inflammatory markers, parameters of body composition (BC) and muscle strength among heavy smokers. A detailed smoking history was obtained from 49 heavy smokers (age = 44 ± 12, pack-years = 31 ± 23). Blood samples were analyzed for levels of glucose, lipids, liver enzymes and C-reactive protein (CRP). Anthropometric measurements included waist circumference and assessment of BC by dual energy X-ray absorptiometry (DEXA) and bioelectrical impedance analysis (BIA). Muscle strength was assessed by handgrip dynamometry and predicted one-repetition maximum (p1RM) tests. Positive correlations were found between pack-years of smoking, fasting glucose, alkaline phosphatase and CRP levels. Pack-years were also positively correlated with waist circumference, body mass index (BMI), whole-body and trunk fat mass measured by both DEXA and BIA. A negative correlation was found between pack-years of smoking and muscle strength measured by p1RM for the leg press exercise. After adjustment for age, sex and BMI, a positive correlation remained between pack-years of smoking and CRP levels. In conclusion, after controlling for possible confounders, smoking history was found to be positively associated with CRP levels among heavy smokers.
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Acknowledgments
This study was supported by grants from the Rappaport Institute, the Krol Foundation of Barnegat N.J., the Myers-JDC-Brookdale Institute of Gerontology and Human Development, and ESHEL – the association for planning and development of services for the aged in Israel.
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The authors declare no conflicts of interest in relation to this manuscript.
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Rom, O., Karkabi, K., Reznick, A.Z., Keidar, Z., Aizenbud, D. (2014). Relationship Between History of Smoking, Metabolic and Inflammatory Markers, Parameters of Body Composition and Muscle Strength. In: Pokorski, M. (eds) Environmental Biomedicine. Advances in Experimental Medicine and Biology(), vol 849. Springer, Cham. https://doi.org/10.1007/5584_2014_92
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DOI: https://doi.org/10.1007/5584_2014_92
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