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DNA replication, recombination, and repair in plastids

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Cell and Molecular Biology of Plastids

Part of the book series: Topics in Current Genetics ((TCG,volume 19))

Abstract

Plastid DNA is conserved, highly polyploid and uniform within a plant reflecting efficientplastid DNA replication/recombination/repair (DNA-RRR) pathways. We will review the current understandingof the DNA sequences, proteins, and mechanisms involved in plastid genome maintenance. This includesanalysis of the topological forms of plastid DNA, models of plastid DNA replication, homologous recombination,replication slippage, DNA repair, and plastid DNA-RRR-proteins. We will focus on flowering plantsbut include information from algae when relevant. Plastid DNA is comprised of a multimeric seriesof circular, linear, and branched forms. Variant plastid DNA molecules include small linear palindromeswith hairpin ends. Plastid transformation has demonstrated an efficient homologous recombinationpathway, acting on short ∼200  bp sequences, that is active throughout shoot development.These functional studies involving plastid transformation to manipulate DNA sequences, combined withgenomics and reverse genetics to isolate mutants in plastid DNA-RRR proteins, will be particularlyimportant for making progress in this field.

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    Anil Day & Panagiotis Madesis

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Day, A., Madesis, P. (2007). DNA replication, recombination, and repair in plastids. In: Bock, R. (eds) Cell and Molecular Biology of Plastids. Topics in Current Genetics, vol 19. Springer, Berlin, Heidelberg. https://doi.org/10.1007/4735_2007_0231

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