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Orexins and Orexin Receptors: From Molecules to Integrative Physiology

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Orphan G Protein-Coupled Receptors and Novel Neuropeptides

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 46))

Abstract

Recent studies have implicated the orexin system as a critical regulator of sleep/wake states, feeding behavior, and reward processes. Orexin deficiency results in narcolepsy-cataplexy in humans, dogs, and rodents, suggesting that the orexin system is particularly important for maintenance of wakefulness. Orexin agonists and antagonists are thought to be promising avenues toward the treatment of sleep disorders, eating disorders, and drug addiction. In this chapter, we discuss the current understanding of the physiological roles of orexins in regulation of arousal, sleep/wake states, energy homeostasis, and reward systems.

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Authors and Affiliations

  1. Department of Pharmacology, Institute of Basic Medical Science, University of Tsukuba, Tsukuba, 305-8575, Ibaraki, Japan

    Taizo Matsuki & Takeshi Sakurai

  2. Yanagisawa Orphan Receptor Project, ERATO, Japan Science and Technology Agency, 135-0064, Tokyo, Japan

    Taizo Matsuki & Takeshi Sakurai

  3. Department of Molecular Neuroscience and Integrative Physiology, Graduate School of Medical Science, Kanazawa University, 920 8640, Kanazawa, Japan

    Taizo Matsuki & Takeshi Sakurai

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  1. Taizo Matsuki
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  2. Takeshi Sakurai
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Correspondence to Takeshi Sakurai .

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Olivier Civelli Qun-Yong Zhou

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Matsuki, T., Sakurai, T. (2008). Orexins and Orexin Receptors: From Molecules to Integrative Physiology. In: Civelli, O., Zhou, QY. (eds) Orphan G Protein-Coupled Receptors and Novel Neuropeptides. Results and Problems in Cell Differentiation, vol 46. Springer, Berlin, Heidelberg. https://doi.org/10.1007/400_2007_047

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