Skip to main content
SpringerLink
Log in

Ion channel regulation

  • Chapter
Antibiotics as Anti-Inflammatory and Immunomodulatory Agents

Part of the book series: Progress in Inflammation Research ((PIR))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Nadel JA, Widdicombe JH, Peatfield AC (1985) Regulation of airway secretions, ion transport, and water movement. In: AP Fishman (eds): The respiratory system. American Physiological Society, Bethesda, 419–45

    Google Scholar 

  2. Suez D, Szefler SJ (1986) Excessive accumulation of mucus in children with asthma: a potential role for erythromycin? A case discussion. J Allergy Clin Immunol 77: 330–4

    PubMed  Google Scholar 

  3. Marom ZM, Goswami SK (1991) Respiratory mucus hypersecretion (bronchorrhea): a case discussion. Possible mechanism(s) and treatment. J Allergy Clin Immunol 87: 1050–5

    PubMed  Google Scholar 

  4. Kadota J, Sakito O, Kohno S, Sawa H, Mukae H, Oda H, Kawakami K, Fukushima K, Hiratani K, Hara K (1993) A mechanism of erythromycin treatment in patients with diffuse panbronchiolitis. Am Rev Respir Dis 147: 153–9

    PubMed  Google Scholar 

  5. Tamaoki J, Takeyama K, Tagaya E, Konno K (1995) Effect of clarithromycin on sputu production and its rheological properties in chronic respiratory tract infections. Antimicrob Agents Chemother 39: 1688–90

    PubMed  Google Scholar 

  6. Takizawa H, Ohtoshi T, Kawasaki S, Kohyama T, Sato M, Tanaka M, Kasama T, Kobayashi K, Nakajima J, Ito K (1997) Erythromycin modulates IL-8 expression in human bronchial epithelial cells: studies with normal and inflamed airway epithelium. Am J Respir Crit Care Med 156: 266–71

    PubMed  Google Scholar 

  7. Tamaoki J, Takeyama K, Yamawaki I, Kondo M, Konno K (1997) Lipopolysaccharide-induced goblet cell hypersecretion in the guinea-pig trachea: inhibition by macrolides. Am J Physiol 272: L15–L19

    PubMed  Google Scholar 

  8. Goswami SK, Kivity S, Marom Z (1990) Erythromycin inhibits respiratory glycoconjugate secretion from human airways in vitro. Am Rev Respir Dis 141: 72–8

    PubMed  Google Scholar 

  9. Welsh MJ (1987) Electrolyte transport by airway epithelia. Physiol Rev 67: 1143–84

    PubMed  Google Scholar 

  10. Boucher RC (1994) State of the art: human airway ion transport. Am J Respir Crit Care Med 150: 581–93

    PubMed  Google Scholar 

  11. Widdicombe JH, Kondo M, Mochizuki SJ (1986) Regulation of airway mucosal ion transport. Int Arch Allergy Appl Immunol 94: 56–61

    Google Scholar 

  12. Tamaoki J, Isono K, Sakai N, Kanemura T, Konno K (1992) Erythromycin inhibits Cl secretion across canine tracheal epithelial cells. Eur Respir J 5: 234–8

    PubMed  Google Scholar 

  13. Hirano M, Miwa M, Saito S, Baba R, Takasu A, Iwata S, Hazama A, Okada Y (1998) Effects of macrolides on electrolyte secretion by airway ciliary epithelial cells. Jpn J Antibiot 51(Suppl): 152–4

    PubMed  Google Scholar 

  14. Shinkawa K, Sone S, Takahashi A, Maeda K, Tanoue N, Nakaya Y (2001) Effects of erythromycin and clarithromycin on chloride channels in bronchial epithelial cells. Jpn J Antibiot 54(Suppl): 59–62

    PubMed  Google Scholar 

  15. Anderson R, Fernandes AC, Eftychis HE (1984) Studies on the effects of ingestion of a single 500 mg oral dose of erythromycin stearate on leucocyte motility and transformation and on release in vitro of prostaglandin E2 by stimulated leucocytes. J Antimicrob Chemother 14: 41–50

    PubMed  Google Scholar 

  16. Johnson JD, Hand WL, Francis JB, King-Thompson N, Corwin RW (1980) Antibiotic uptake by alveolar macrophages. J Lab Clin Med 95: 429–39

    PubMed  Google Scholar 

  17. Ikeda K, Wu D, Takasaka T (1995) Inhibition of acetylcholine-evoked Cl- currents by 14-membered macrolide antibiotics in isolated acinar cells of the guinea pig nasal gland. Am J Respir Cell Mol Biol 13: 449–54

    PubMed  Google Scholar 

  18. Tamaoki J, Takemura H, Tagaya E, Konno K (1995) Effect of clarithromycin on transepithelial potential difference in rabbit tracheal mucosa. J Infect Chemother 1: 112–15

    Google Scholar 

  19. MacCall E, Li L, Sato H, Shannon TR, Blatter LA, Bers DM (1996) Effects of FK-506 on contraction and Ca2+ transients in rat cardiac myocytes. Circ Res 79: 1110–21

    PubMed  Google Scholar 

  20. Kanoh S, Kondo M, Tamaoki J, Shirakawa H, Kobayashi H, Nagata N, Konno K (1997) FK506 inhibits ATP-induced intracellular calcium rise in trachaeal epithelium. Am J Respir Crit Care Med 155: A609 (Abstr)

    Google Scholar 

  21. Kondo M, Konoh S, Tamaoki J, Shirakawa H, Miyazaki S, Nagai A (1998) Erythromycin inhibits ATP-induced intracellular calcium responses in bovine tracheal epithelial cells. Am J Respir Cell Mol Biol 19: 799–804

    PubMed  Google Scholar 

  22. Zhao DM, Xue HH, Chida K, Suda T, Oki Y, Kanai M, Uchida C, Ichiyama A, Nakamura H (2000) Effect of erythromycin on ATP-induced intracellular calcium response in A549_cells. Am J Physiol Lung Cell Mol Physiol 278: L726–L736

    PubMed  Google Scholar 

  23. Rubin BK, Druce H, Ramirez OE, Palmer R (1997) Effect of clarithromycin on nasal mucus properties in healthy subjects and in patients with purulent rhinitis. Am J Respir Crit Care Med 155: 2018–23

    PubMed  Google Scholar 

  24. Tagaya E, Tamaoki J, Kondo M, Nagai A (2002) Effect of a short course clarithromycin therapy on sputum production in patients with chronic airway hypersecretion. Chest 122: 213–18

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. First Department of Medicine, Tokyo Women’s Medical University School of Medicine, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan

    Jun Tamaoki

Authors
  1. Jun Tamaoki
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Pediatrics School of Medicine, Wake Forest University, Medical Center Boulevard, Winston-Salem, NC, 27157-1081, USA

    Bruce K. Rubin

  2. First Department of Medicine, Tokyo Women’s Medical University, 8-1 Kawada-Cho, Shinjuku, Tokyo, 162-8666, Japan

    Jun Tamaoki

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Birkhäuser Verlag Basel/Switzerland

About this chapter

Cite this chapter

Tamaoki, J. (2005). Ion channel regulation. In: Rubin, B.K., Tamaoki, J. (eds) Antibiotics as Anti-Inflammatory and Immunomodulatory Agents. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7310-5_9

Download citation

  • DOI: https://doi.org/10.1007/3-7643-7310-5_9

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-7643-5925-6

  • Online ISBN: 978-3-7643-7310-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation