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Transition and main-group metal cyclopentadienyl complexes: Preclinical studies on a series of antitumor agents of different structural type

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Bioinorganic Chemistry

Part of the book series: Structure and Bonding ((STRUCTURE,volume 70))

Abstract

Cyclopentadienyl metal complexes are organometallic compounds which exhibit antiproliferative properties in vivo and in vitro. They are represented by compounds of various structural type. The metallocene diacido complexes (C5H5)2MX2 contain early transition metal atoms such as titanium(IV) and vanadium(IV), the ionic metallicenium salts [(C5H5)2M]+X− include medium transition metals, e.g. iron(III), whereas the uncharged decasubstituted metallocenes (C5R5)2M comprise the main group elements tin(II) and germanium(II) as central metal atoms M. A variety of biological data are available about metallocene diacido complexes, especially titanocene dichloride. These substances exhibit antitumor properties against numerous experimental tumors, e.g. Ehrlich ascites tumor, B 16 melanoma, colon 38 carcinoma, Lewis lung carcinoma, as well as against various human tumors heterotransplanted to athymic mice. Biological experiments using (C5H5)2TiCl2 and (C5H5)2VCl2 pointed to the nucleic acids as a probable target for metallocene diacido complexes within the cells, revealed a main accumulation of titanium or vanadium in the liver and the intestine and unfolded a pattern of organ toxicity which fundamentally differs from that of other cytostatic drugs. These biological features confirm the cyclopentadienyl metal complexes to be an independent group of non-platinum-group metal antitumor agents being characterized by unusual biological properties. They represent interesting candidates for future biological and clinical investigations.

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Abbreviations

ID50 :

concentration effecting 50% inhibition of cellular proliferation in vitro

ED90 :

dose effecting complete tumor regression in 90% of the animals treated

LD50, LD100 :

doses killing 50 or 100%, resp., of the animals treated

T.I.:

therapeutic index, defined as the relation of a lethal dose (LD50) to a therapeutic dose (ED90)

T/C:

ratio of tumor weights of treated and untreated (control) tumors. Values less than 50% are cnsidered significant.

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Authors and Affiliations

  1. Institut für Anatomie, Freie Universität Berlin, Königin-Luise-Straße 15, D-1000, Berlin 33

    Petra Köpf-Maier

  2. Institut für Anorganische and Analytische Chemie, Technische Universität Berlin, Straße des 17. Juni 135, D-1000, Berlin 12

    Hartmut Köpf

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  1. Petra Köpf-Maier
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  2. Hartmut Köpf
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© 1988 Springer-Verlag

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Köpf-Maier, P., Köpf, H. (1988). Transition and main-group metal cyclopentadienyl complexes: Preclinical studies on a series of antitumor agents of different structural type. In: Bioinorganic Chemistry. Structure and Bonding, vol 70. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-50130-4_3

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  • DOI: https://doi.org/10.1007/3-540-50130-4_3

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