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Design and Construction of Novel Peptides and Proteins by Tailored Incorporation of Coenzyme Functionality

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Implementation and Redesign of Catalytic Function in Biopolymers

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 202))

Abstract

Recent research in a number of laboratories has focused on devising strategies for the integration of coenzyme functionality into non-native biopolymer scaffolds. The goal of this research is to influence the inherent chemical reactivity of coenzymes to generate unique molecules with novel functional properties. This review will discuss the progress made in this area and delineate the issues involved in using polypeptides and proteins to harness the chemical properties of selected coenzymes. The specific coenzymes that will be presented in this review are pyridoxal phosphate, thiazolium pyrophosphate, flavin and nicotinamide adenine dinucleotide.

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Author information

Authors and Affiliations

  1. Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA

    Barbara Imperiali, Kevin A. McDonnell & Michael Shogren-Knaak

Authors
  1. Barbara Imperiali
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  2. Kevin A. McDonnell
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  3. Michael Shogren-Knaak
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Editor information

Editors and Affiliations

  1. Institut für Organische Chemie und Biochemie, Technische Universität München, D-85747, Garching, Germany

    Franz P. Schmidtchen

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© 1999 Springer-Verlag Berlin Heidelberg

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Imperiali, B., McDonnell, K.A., Shogren-Knaak, M. (1999). Design and Construction of Novel Peptides and Proteins by Tailored Incorporation of Coenzyme Functionality. In: Schmidtchen, F.P., et al. Implementation and Redesign of Catalytic Function in Biopolymers. Topics in Current Chemistry, vol 202. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-48990-8_1

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  • DOI: https://doi.org/10.1007/3-540-48990-8_1

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  • Print ISBN: 978-3-540-65728-6

  • Online ISBN: 978-3-540-48990-0

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