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Contrast Agents for Optical Imaging

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Contrast Agents II

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 222))

Abstract

Optical imaging encompasses many different techniques which use light of the UV to the NIR spectral region to visualize tissue optical characteristics imparted through absorption and scattering of light, as well as emission of fluorescence. A variety of different probes for optical detection of diseases have been synthesized and characterized for their potential to engender disease-specific optical signals within the tissue. This review summarizes the essential literature in this research field, especially covering the chemistry of novel biocompatible probes from the cyanine dyes, tetrapyrroles, lanthanide chelates and some other entities. Different chemical, optical and pharmocological properties were exploited to provide extracellular dyes, target-specific conjugates, activatable probes or pro-drugs. In selected examples, the synthesis of such agents and their mode of action is described and accompanied with in vivo data demonstrating their diagnostic efficacy. Finally, a summary of medical applications is given with emphasis on the current and future role of optical contrast agents. Further progress in the design of designated dyes will be of great value for the establishment of novel optical diagnostic methods in routine clinical practice.

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  1. Research Laboratories, Schering AG, Müllerstr. 170-178, 13342, Berlin, Germany

    Kai Licha

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  1. International Project Management Therapeutics, Schering AG, 13342, Berlin, Germany

    Werner Krause

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© 2002 Springer-Verlag Berlin Heidelberg

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Licha, K. (2002). Contrast Agents for Optical Imaging. In: Krause, W. (eds) Contrast Agents II. Topics in Current Chemistry, vol 222. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-46009-8_1

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  • DOI: https://doi.org/10.1007/3-540-46009-8_1

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