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Oxidative stress responses in yeast

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Yeast Stress Responses

Part of the book series: Topics in Current Genetics ((TCG,volume 1))

Abstract

Yeast, and especially S. cerevisiae, is a unique eukaryotic model organism for studying oxidative stress and its cellular responses. S. cerevisiae has become a very powerful tool to decipher the complexity of these biologically important responses, because it offers the relative simplicity of a single celled eukaryotic organism that enables the combination and integration of genetic, biochemical, physico-chemical, cell biological, and genome-wide experimental approaches. We introduce the subject with basic concepts about reactive oxygen species (ROS) and explain their cellular toxicity and the experimental approaches that have been adapted to their analysis. Subsequently, we summarize some of the knowledge obtained in the yeast model of the cellular effects of ROS, the antioxidant and thiol redox control systems, and the cellular responses to elevated ROS concentrations. Cellular responses to ROS concentrations are often referred to as adaptive oxidative stress responses. Special attention is given to the signal transduction pathways that regulate these responses in S. cerevisiae, S. pombe, and other fungi. Emphasis is given to the systems that sense elevated ROS concentrations. Important links between oxidative stress responses, carbohydrate metabolism, respiration and the mitochondria, iron and copper metabolism, cell cycle control and yeast apoptotic-like responses are also dealt with here. The data reviewed in this article illustrates how much our understanding of the biology of oxidants has advanced, and how much research is still needed to unravel its complexity.

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Authors and Affiliations

  1. Laboratoire Stress Oxydants et Cancer, CBA-Saclay, France

    Michel B. Toledano, Agnes Delaunay, Benoit Biteau, Daniel Spector & Dulce Azevedo

  2. Florida Atlantic, University Center for Molecular Biology and Biotechnology, USA

    Daniel Spector

  3. Genomic and stress, ITQB, Portugal

    Dulce Azevedo

Authors
  1. Michel B. Toledano
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  2. Agnes Delaunay
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  3. Benoit Biteau
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  4. Daniel Spector
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  5. Dulce Azevedo
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  1. Department of Cell and Molecular Biology/Microbiology, Göteborg University, Box 462, 405 30, Göteborg, Sweden

    Stefan Hohmann

  2. Department of Biochemistry & Molecular Biology Division of Scheikunde, Vrije Universiteit, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands

    Willem H. Mager

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Toledano, M.B., Delaunay, A., Biteau, B., Spector, D., Azevedo, D. (2003). Oxidative stress responses in yeast. In: Hohmann, S., Mager, W.H. (eds) Yeast Stress Responses. Topics in Current Genetics, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-45611-2_6

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  • DOI: https://doi.org/10.1007/3-540-45611-2_6

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