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The Role of Hormones in Intrinsic Aging

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Skin Aging

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Reference

  1. Zouboulis CC (2000) Human skin: an independent peripheral endocrine organ. Horm Res 54:230–242

    CAS  PubMed  Google Scholar 

  2. Ebling FJG (1990) The hormonal control of hair growth. In: Orfanos CE, Happle R, (eds) Hair and hair growth. Springer, Berlin Heidelberg New York, pp 267–99

    Google Scholar 

  3. Fritsch M, Orfanos CE, Zouboulis CC (2001) Sebocytes are the key regulators of androgen homeostasis in human skin. J Invest Dermatol 116:793–800

    Article  CAS  PubMed  Google Scholar 

  4. Suzuki I, Cone CD, Im S, Nordlund J, Abdel-Malek ZA (1996) Binding of melanocortin hormones to the melanocortin receptor MC1R on human melanocytes stimulates proliferation and melanogenesis. Endocrinology 137:1627–1633

    CAS  PubMed  Google Scholar 

  5. Deplewski D, Rosenfield RL (2000) Role of hormones in pilosebaceous unit development. Endocr Rev 21:363–392

    Article  CAS  PubMed  Google Scholar 

  6. Stenn KS, Paus R (2001) Control of hair follicle cycling. Physiol Rev 81:449–494

    CAS  PubMed  Google Scholar 

  7. Labrie F, Luu-The V, Labrie C, Pelletier G, El-Alfy M (2000) Intracrinology and the skin. Horm Res 54:218–229

    Article  CAS  PubMed  Google Scholar 

  8. Orfanos CE, Adler YD, Zouboulis CC (2000) The SAHA syndrome. Horm Res 54:251–258

    Article  CAS  PubMed  Google Scholar 

  9. Phillips TJ, Demircay Z, Sahu M (2001) Hormonal effects on skin aging. Clin Geriatr Med 17:661–672

    Article  CAS  PubMed  Google Scholar 

  10. Thiboutot DM (1995) Dermatological manifestations of endocrine disorders. J Clin Endocrinol Metab 80:3082–3087

    Article  CAS  PubMed  Google Scholar 

  11. Greenspan FS, Gardner DG (2001) Basic and clinical endocrinology, 6th edn. McGraw Hill, New York

    Google Scholar 

  12. Brincat MP (2000) Hormone replacement therapy and the skin. Maturitas 35:107–117

    Article  CAS  PubMed  Google Scholar 

  13. Morley JE (2001) Androgens and aging. Maturitas 38:61–73

    Article  CAS  PubMed  Google Scholar 

  14. Callens A, Vaillant L, Lecomte P, Berson M, Gall Y, Lorette G (1996) Does hormonal skin aging exist? A study of the influence of different hormone therapy regimens on the skin of postmenopausal women using non-invasive measurement techniques. Dermatology 193:289–294

    CAS  PubMed  Google Scholar 

  15. Rudman D, Feller AG, Nagraj HS, Gergans GA, Lalitha PY, Goldberg AF, Schlenker RA, Cohn L, Rudman IW, Mattson DE (1990) Effects of human growth hormone in men over 60 years old. N Engl J Med 323:1–6

    CAS  PubMed  Google Scholar 

  16. Raine-Fenning NJ, Brincat MP, Muscat-Baron Y (2003) Skin aging and menopause: implications for treatment. Am J Clin Dermatol 4:371–378

    Article  PubMed  Google Scholar 

  17. Sator PG, Schmidt JB, Rabe T, Zouboulis CC (2004) Skin aging and sex hormones in women — clinical perspectives for intervention by hormone replacement therapy. Exp Dermatol 13[Suppl 4]:36–40

    CAS  PubMed  Google Scholar 

  18. Dieudonne MN, Pecquery R, Leneveu MC, Giudicelli Y (2000) Opposite effects of androgens and estrogens on adipogenesis in rat preadipocytes: evidence for sex and site-related specificities and possible involvement of insulin-like growth factor 1 receptor and peroxisome proliferator-activated receptor γ2. Endocrinology 141:649–656

    Article  CAS  PubMed  Google Scholar 

  19. Tavakkol A, Varani J, Elder JT, Zouboulis CC (1999) Maintenance of human skin in organ culture: role for insulin-like growth factor-1 receptor and epidermal growth factor receptor. Arch Dermatol Res 291:643–651

    Article  CAS  PubMed  Google Scholar 

  20. Ma H, Sprecher HW, Kolattukudy PE (1998) Estrogen-induced production of a peroxisome proliferator-activated receptor (PPAR) ligand in a PPARγ-expressing tissue. J Biol Chem 273:30131–30138

    CAS  PubMed  Google Scholar 

  21. Rosenfield RL, Kentsis A, Deplewski D, Ciletti N (1999) Rat preputial sebocyte differentiation involves peroxisome proliferator-activated receptors. J Invest Dermatol 112:226–232

    Article  CAS  PubMed  Google Scholar 

  22. Miller KK (2001) Androgen deficiency in women. J Clin Endocrinol Metab 86:2395–2401

    CAS  PubMed  Google Scholar 

  23. Makrantonaki E, Oeff MK, Fimmel S, Zouboulis CC (2003) Molecular mechanisms of hormone-induced skin aging. Exp Dermatol 12:333

    Google Scholar 

  24. Chen W, Yang C-C, Sheu H-M, Seltmann H, Zouboulis CC (2003) Expression of peroxisome proliferator-activated receptor and CCAAT/enhancer binding protein transcription factors in cultured human sebocytes. J Invest Dermatol 121:441–447

    Article  CAS  PubMed  Google Scholar 

  25. Oettel M (2002) Is there a role for estrogens in the maintenance of men’s health? Aging Male 5:248–257

    CAS  PubMed  Google Scholar 

  26. Katz MS (2000) Geriatric grand rounds: Eve’s rib, or a revisionist view of osteoporosis in men. J Gerontol A Biol Sci Med Sci 55:M560–569

    CAS  PubMed  Google Scholar 

  27. Brossner C, Petritsch K, Fink K, Auprich M, Madersbacher S, Adlercreutz H, Rehak P, Petritsch P (2004) Phytoestrogen tissue levels in benign prostatic hyperplasia and prostate cancer and their association with prostatic diseases. Urology 64:707–711

    Article  PubMed  Google Scholar 

  28. Ponholzer A, Plas E, Schatzl G, Jungwirth A, Madersbacher S (2002) Austrian Society of Urology. Association of DHEA-S and estradiol serum levels to symptoms of aging men. Aging Male 5:233–238

    CAS  PubMed  Google Scholar 

  29. Juul A, Skakkebaek NE (2002) Androgens and the ageing male. Hum Reprod Update 8:423–433

    Article  CAS  PubMed  Google Scholar 

  30. Von Eckardstein S, Nieschlag E (2000) Therapie mit Sexualhormonen beim alternden Mann. Dt Ärztebl 97:A3175–3182

    Google Scholar 

  31. Kao JS, Garg A, Mao-Qiang M, Crumrine D, Ghadially R, Feingold KR, Elias PM (2001) Testosterone perturbs epidermal permeability barrier homeostasis. J Invest Dermatol 116:443–451

    Article  CAS  PubMed  Google Scholar 

  32. Gilliver SC, Wu F, Ashcroft GS (2003) Regulatory roles of androgens in cutaneous wound healing. Thromb Haemost 90:978–985

    CAS  PubMed  Google Scholar 

  33. Gambera A, Scagliola P, Falsetti L, Sartori E, Bianchi U (2004) Androgens, insulin-like growth factor-I (IGF-I), and carrier proteins (SHBG, IGFBP-3) in postmenopause. Menopause 11:159–166

    PubMed  Google Scholar 

  34. Ghizzani A, Razzi S, Fava A, Sartini A, Picucci K, Petraglia F (2003) Management of sexual dysfunctions in women. J Endocrinol Invest 26[Suppl 3]:137–138

    CAS  PubMed  Google Scholar 

  35. Buvat J (2003) Androgen therapy with dehydroepiandrosterone. World J Urol 21:346–355

    Article  CAS  PubMed  Google Scholar 

  36. Hennessey JV, Chromiak JA, DellaVentura S, Reinert SE, Puhl J, Kiel DP, Rosen CJ, Vandenburgh H, MacLean DB (2001) Growth hormone administration and exercise effects on muscle fiber type and diameter in moderately frail older people. J Am Geriatr Soc 49:852–858

    Article  CAS  PubMed  Google Scholar 

  37. Kann PH (2003) Growth hormone in anti-aging medicine: a critical review. Aging Male 6:257–263

    CAS  PubMed  Google Scholar 

  38. Harman SM, Blackman MR (2004) Use of growth hormone for prevention or treatment of effects of aging. J Gerontol A Biol Sci Med Sci 59:652–658

    PubMed  Google Scholar 

  39. Savine R, Sonksen P (2000) Growth hormone — hormone replacement for the somatopause? Horm Res 53[Suppl 3]:37–41

    CAS  PubMed  Google Scholar 

  40. Mauras N, Rini A, Welch S, Sager B, Murphy SP (2003) Synergistic effects of testosterone and growth hormone on protein metabolism and body composition in prepubertal boys. Metabolism 52:964–969

    Article  CAS  PubMed  Google Scholar 

  41. Prakasam G, Yeh JK, Chen MM, Castro-Magana M, Liang CT, Aloia JF (1999) Effects of growth hormone and testosterone on cortical bone formation and bone density in aged orchiectomized rats. Bone 24:491–497

    Article  CAS  PubMed  Google Scholar 

  42. Lissett CA, Shalet SM (2003) The insulin-like growth factor-I generation test: peripheral responsiveness to growth hormone is not decreased with ageing. Clin Endocrinol (Oxf) 58:238–245

    Article  CAS  Google Scholar 

  43. Weber MM (2002) Effects of growth hormone on skeletal muscle. Horm Res 58[Suppl 3]:43–48

    CAS  PubMed  Google Scholar 

  44. Akamatsu H, Zouboulis CC, Orfanos CE (1992) Control of human sebocyte proliferation in vitro by testosterone and 5-alpha-dihydrotestosterone is dependent on the localization of the sebaceous glands. J Invest Dermatol 99:509–511

    Article  CAS  PubMed  Google Scholar 

  45. Deplewski D, Rosenfield RL (1999) Growth hormone and insulin-like growth factors have different effects on sebaceous cell growth and differentiation. Endocrinology 140:4089–4094

    Article  CAS  PubMed  Google Scholar 

  46. Zouboulis CC, Makrantonaki E (2003) Molekulare Mechanismen der hormonellen Hautalterung. J Dtsch Dermatol Gesellschaft 1[Suppl 1]:S94

    Google Scholar 

  47. Ruiz-Torres A, Soares de Melo Kirzner M (2002) Ageing and longevity are related to growth hormone/ insulin-like growth factor-1 secretion. Gerontology 48:401–407

    Article  CAS  PubMed  Google Scholar 

  48. Lee KS, Oh KY, Kim BC (2000) Effects of dehydroepiandrosterone on collagen and collagenase gene expression by skin fibroblasts in culture. J Dermatol Sci 23:103–110

    CAS  PubMed  Google Scholar 

  49. Baulieu E-E, Thomas G, Legrain S, Lahlou N, Roger M, Debuire B, Faucounau V, Girard L, Hervy M-P, Latour F, Leaud M-C, Mokrane A, Pitti-Ferrandi H, Trivalle C, de Lacharrière O, Nouveau S, Rakoto-Arison B, Souberbielle J-C, Raison J, Le Bouc Y, Raynaud A, Girerd X, Forette F (2000) Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge Study to a sociobio-medical issue. Proc Natl Acad Sci U S A 97:4279–4284

    Article  CAS  PubMed  Google Scholar 

  50. Percheron G, Hogrel JY, Denot-Ledunois S, Fayet G, Forette F, Baulieu EE, Fardeau M, Marini JF (2003) Double-blind placebo-controlled trial. Effect of 1-year oral administration of dehydroepiandrosterone to 60-to 80-year-old individuals on muscle function and cross-sectional area: a double-blind placebo-controlled trial. Arch Intern Med 163:720–727

    Article  CAS  PubMed  Google Scholar 

  51. Genazzani AR, Inglese S, Lombardi I, Pieri M, Bernardi F, Genazzani AD, Rovati L, Luisi M (2004) Long-term low-dose dehydroepiandrosterone replacement therapy in aging males with partial androgen deficiency. Aging Male 7:133–143

    CAS  PubMed  Google Scholar 

  52. Allolio B, Arlt W (2002) DHEA treatment: myth or reality? Trends Endocrinol Metab 13:288–294

    CAS  PubMed  Google Scholar 

  53. Huber J, Gruber C (2001) Immunological and dermatological impact of progesterone. Gynecol Endocrinol 15[Suppl 6]:18–21

    PubMed  Google Scholar 

  54. Wieser F, Hosmann J, Tschugguel W, Czerwenka K, Sedivy R, Huber JC (2001) Progesterone increases the number of Langerhans cells in human vaginal epithelium. Fertil Steril 75:1234–1235

    Article  CAS  PubMed  Google Scholar 

  55. Mingjia L, Short R (2002) How oestrogen or progesterone might change a woman’s susceptibility to HIV-1 infection. Aust N Z J Obstet Gynaecol 42:472–475

    Article  PubMed  Google Scholar 

  56. Fischer TW, Elsner P (2001) The antioxidative potential of melatonin in the skin. Curr Probl Dermatol 29:165–174

    CAS  PubMed  Google Scholar 

  57. Abdel-Wahhab MA, Abdel-Galil MM, El-Lithey M (2005) Melatonin counteracts oxidative stress in rats fed an ochratoxin A contaminated diet. J Pineal Res 38:130–135

    Article  CAS  PubMed  Google Scholar 

  58. Fischer TW, Greif C, Fluhr JW, Wigger-Alberti W, Elsner P (2004) Percutaneous penetration of topically applied melatonin in a cream and an alcoholic solution. Skin Pharmacol Physiol 17:190–194

    Article  CAS  PubMed  Google Scholar 

  59. Fischer T, Bangha E, Elsner P, Kistler GS (1999) Suppression of UV-induced erythema by topical treatment with melatonin. Influence of the application time point. Biol Signals Recept 8:132–135

    Article  CAS  PubMed  Google Scholar 

  60. Wespes E, Schulman CC (2002) Male andropause: myth, reality, and treatment. Int J Impot Res 14[Suppl 1]:S93–98

    PubMed  Google Scholar 

  61. Traustadottir T, Bosch PR, Matt KS (2005) The HPA axis response to stress in women: effects of aging and fitness. Psychoneuroendocrinology 30:392–402

    Article  CAS  PubMed  Google Scholar 

  62. Kaplan MM, Pan CY, Gordon PR, Lee JK, Gilchrest BA (1988) Human epidermal keratinocytes in culture convert thyroxine to 3,5,3′-triiodothyronine by type II iodothyronine deiodination: a novel endocrine function of the skin. J Clin Endocrinol Metab 66:815–822

    CAS  PubMed  Google Scholar 

  63. Morrow LB (1978) How thyroid disease presents in the elderly. Geriatrics 33:42–45

    CAS  PubMed  Google Scholar 

  64. Mirza FS, Prestwood KM (2004) Bone health and aging: implications for menopause. Endocrinol Metab Clin North Am 33:741–759

    Article  CAS  PubMed  Google Scholar 

  65. Vieth R, Ladak Y, Walfish PG (2003) Age-related changes in the 25-hydroxyvitamin D versus parathyroid hormone relationship suggest a different reason why older adults require more vitamin D. J Clin Endocrinol Metab 88:185–191

    Article  CAS  PubMed  Google Scholar 

  66. Dawson-Hughes B (2004) Racial/ethnic considerations in making recommendations for vitamin D for adult and elderly men and women. Am J Clin Nutr 80[Suppl 6]:1763S–1766S

    CAS  PubMed  Google Scholar 

  67. Zouboulis CC (2004) The human skin as a hormone target and an endocrine gland. Hormones 3:9–26

    Google Scholar 

  68. Cao T, Tsai SY, O’Malley BW, Wang XJ, Roop DR (2002) The epidermis as a bioreactor: topically regulated cutaneous delivery into the circulation. Hum Gene Ther 13:1075–1080

    Article  CAS  PubMed  Google Scholar 

  69. Lemmey AB, Glassford J, Flick-Smith HC, Holly JM, Pell JM (1997) Differential regulation of tissue insulin-like growth factor-binding protein (IGFBP)-3, IGF-I and IGF type 1 receptor mRNA levels, and serum IGF-I and IGFBP concentrations by growth hormone and IGF-I. J Endocrinol 154:319–328

    Article  CAS  PubMed  Google Scholar 

  70. Zouboulis CC, Degitz K (2004) Androgen action on human skin — from basic research to clinical significance. Exp Dermatol 13[Suppl 4]:5–10

    CAS  PubMed  Google Scholar 

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Zouboulis, C.C., Makrantonaki, E. (2006). The Role of Hormones in Intrinsic Aging. In: Gilchrest, B.A., Krutmann, J. (eds) Skin Aging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-32953-6_6

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  • DOI: https://doi.org/10.1007/3-540-32953-6_6

  • Publisher Name: Springer, Berlin, Heidelberg

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