Zusammenfassung
Die Ursache der idiopathischen thrombozytopenischen Purpura (ITP) ist noch weitgehend unbekannt. Die Pathophysiologie ist (auto-)immunologisch. Erkenntnisse der veränderten Kaskade der Immunantwort führten zu modernen biologischen Therapieansätzen. Prospektive kooperative Studien zeigen neue Aspekte der Demographie, des Verlaufs und der Betreuung bzw. Behandlung von Kindern mit ITP auf.
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Literatur
Ahn YS, Harrington WJ, Seelman RC et al (1974) Vincristine therapy of idiopathic and secondary thrombocytopenias. N Engl J Med 291:376
Andersen JC (1994) Response of resistant idiopathic thrombocytopenic purpura to pulsed high-dose demamethasone therapy. N Engl J Med 330:1560–1564
Andrew M, Blanchette V, Adams M et al (1991) A multicenter study of the treatment of childhood chronic idiopathic thrombocytopenic purpura with anti-D. J Pediatr 120:522–527
Aronis S, Platokouki H, Mitsika A et al (1995) Treatment of chronic idopathic thrombocytopenic purpura. Pediatr Hematol Oncol 12:409–410
Balint J, Quagliata F, Cochran SK et al (1995) Association of anti-platelet IgG antibody levels with response to extracorporeal protein A/silica Immunoadsorption in ITP patients. Am J of Hematol 50:74–75
Blanchette V, Imbach P, Andrew M et al (1994) Randomized trial of intravenous immunoglobulin G, intravenous anti-D, and oral prednisone in childhood acute immune thrombocytopenic purpura. Lancet 344:703
Blanchette V, Luke B, Anrew M et al (1993) A prospective, randomized trial of high-dose intravenous immune globulin G therapy, oral prednisone therapy, and no therapy in childhood acute immune thrombocytopenic purpura. J Pediatr 123:989
Brighton TA, Evans S, Castaldi PA et al (1996) Prospective evaluation of the clinical usefulness of an antigen-specific assay (MAIPA) in idiopathic thrombocytopenic purpura and other immune thrombocytopenias. Blood 88:194–201
Buchanan GR, Holtkamp CA (1984) Prednisone therapy for children with newly diagnosed idiopathic thrombocytopenic purpura. A randomized clinical trial. Am J Pediatr Hematol Oncol 6:355
Bussel JB, Graziano JN, Kimberly RP et al (1991) Intravenous anti-D treatment of immune thrombocytopenic purpura: Analysis of efficacy, toxicity, and mechanism of effect. Blood 77:1884
Bussel JB, Saal S, Gordon B (1988) Combined plasma exchange and intravenous gammaglobulin in the treatment of patients with refractory immune thrombocytopenic purpura. Transfusion 28:38
Centers for Disease Control and Prevention (1994) Outbreak of hepatitis C associated with intravenous immunoglobulin administration — United States, October 1993–June 1994. Morb Mortal Wkly Rep 43:505
Davis PW, Williams DA, Shamberger RC (1991) Immune thrombocytopenia: Surgical therapy and predictors of response. J Pediatr Surg 26:407
Dietrich S, Kaverl SV, Kazatchkine MD (1992) Modulation of autoimmunity by intravenous globulin through interaction with the functions of the immune/idiotypic network. Clin Immunol Immunopathol 62:873–881
Dubbeld P, Hillen HFP, Schouten HC (1994) Interferon treatment of refractory idiopathic thrombocytopenic purpura (ITP). Eur J Haematol 52:233
Duhem C, Dicato MA, Ries F (1994) Side-effects of intravenous immune globulins. Clin Exp Immunol 97:79
Emilia G, Morselli M, Luppi M et al (2002) Long-term salvage therapy with cyclosporin in refractory idiopathic thrombocytopenic purpura. Blood 99:1482–1485
Emmons RVB, Reid DM, Cohen RL et al (1996) Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction. Blood 87:4068–4071
Facon T, Caulier MT, Wattel E et al (1994) A randomized trial comparing vinblastine in slow infusion and by bolus i.v. injection in idiopathic thrombocytopenic purpura: A report on 42 patients. Br J Haematol 86:678
Flores A, Carles J, Junca J et al (1990) Danazol therapy in chronic immune thrombocytopenic purpura. Eur J Haematol 45:109
Gaines AR (2000) Acute onset hemoglobinemia and/or hemogloinuria and sequelae following Rho(D) immune globulin intravenous administration in immune thrombocytopenic purpura patients. Blood 95:2523–2529
George JN, Woolf SH, Raskob GE et al (1996) Idiopathic thrombocytopenic purpura; A practice guidline developed by explicit methods for the American Society of Hematology. Blood 88:3–40
Halperin DS, Doyle JJ (1988) Is bone marrow examination justified in idiopathic thrombocytopenic purpura? Am J Dis Child 142:509
Harrington WJ, Minnich V, Hollingsworth JW et al (1951) Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic purpura. J Lab Clin Med 38:1–10
Heyns AP, Lotter MG, Badenhorst PN et al (1982) Kinetics and sites of destruction of 111-indium-oxine-labeled platelets in idiopathic thrombocytopenic purpura: a quantitative study. Am J Haematol 12:167–177
Hudson JG, Yates P, Scott GL (1992) Further concern over use of alpha-interferon in immune thrombocytopenic purpura. Br J Haematol 82:630
Huhn RD, Read EJ, Rick M et al (1999) Intensive immunosuppression with high-dose cyclophosphamide and autologous CD34+ selected hematopoietic cell support for chronic refractory autoimmune thrombocytopenia (abstract). Blood 94:178
Imbach P (2003) Refractory idiopathic immune thrombocytopenic purpura in children — current and future treatment options. Ped Drugs 5:795–801
Imbach P, Akatsuka J, Blanchette V et al (1995) Immunthrombocytopenic purpura as a model for pathogenesis and treatment of autoimmunity. Eur J Pediatr 154(3):60–64
Imbach P, Barandun S, D’Apuzzo V et al (1981) High-dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura in childhood. Lancet 1:1228–1231
Imbach P, Kühne T, Holländer G (1997) Immunologic aspects in pathogenesis and treatment of immune thrombocytopenic purpura (ITP) in children. Current Opinion Pediatr 9:35–40
Imbach P, Kühne T, Signer E (2002) Historical aspects and present knowledge of idiopathic thrombocytopenic purpura. Br J Haemat 119:894–900
Imbach P, Luginbühl L, Späth P et al (1985) Cyclosporin A (CyA) and intravenous immunoglobulin (i.v. IgG) in chronic immune thrombocytopenic purpura (ITP) in childhood: a clinical and immunological study (progress report). In: Schindler R (ed) Cyclosporin in autoimmune disease,pp 268–269. Springer, Berlin Heidelberg
Imholz B, Imbach P, Baumgartner C et al (1988) Intravenous immunoglobulin (i.v. IgG) for previously treated acute or for chronic idiopathic thrombocytopenic purpura (ITP) in childhood: A prospective multicenter study. Blut 56: 63
Karpatkin S, Fotino M, Winchester R (1981) Hereditiy autoimmune thrombocytopenic purpura: an immunologic and genetic study. Ann Intern Med 94:781–782
Kattamis AC, Shankar S, Cohen AR (1997) Neurologic complications of treatment of childhood acute immune thrombocytopenic purpura with intravenously administered immunoglobulin G. J Pediatr 130:281–283
Kiefel V, Santoso S, Weisheit M et al (1987) Monolocal antibody-specific immobilization of platelet antigens (MAIPA): a new tool for the identification of platelet-reactive antibodies. Blood 70:1722–1726
Kühne T, Freedman J, Semple JW et al (1997) Platelet and immune responses to oral cyclic dexamethasone therapy in childhood chronic immune thrombocytopenoc purpura. Pediatr 130:17–24
Kühne T, Imbach P, Bolton-Maggs PHB et al for the Intercontinental Childhood ITP Study Group (2001) Newly diagnosed idiopathic thrombocytopenic purpura in childhood: an observational study. Lancet 358: 2122–2125
Laster AJ, Conley CL, Kickler TS et al (1982) Chronic immune thrombocytopenic purpura in monozygotic twins: genetic factos predisposing to immune thrombocytopenic purpura. N Engl J Med 307:1495–1498
Lilleyman JS (1994) Intracranial hemorrhage in idiopathic thrombocytopenic purpura. Arch Dis Child 71: 251–253
Marder VJ, Nusbacher J, Anderson FW (1981) One-year follow-up of plasma exchange therapy in 14 patients with idiopathic thrombocytopenic purpura. Transfusion 21:291
Matthey F, Ardeman S, Jones L et al (1990) Bleeding in immune thrombocytopenic purpura after alpha-interferon. Lancet 335:471
McMillan R, Tani P, Millard F et al (1987) Platelet-associated and plasma anti-glycoprotein autoantibodies in chronic ITP. Blood 70:1040–1045
Ozsoylu S, Irken G, Karabent A (1989) High-dose intravenous methyl-prednisolone for acute childhood idiopathic thrombocytopenic purpura. Eur J Haematol 42:431
Proctor SJ, Jackson G, Carey P et al (1989) Improvement of platelet counts in steroid-unresponsive idiopathic immune thrombocytopenic purpura after short-course therapy with recombinant alpha 2b interferon. Blood 74: 1894–1897
Quiquandon I, Fenaux P, Caulier MT et al (1990) Re-evaluation of the role of azathioprine in the treatment of adult chronic idiopathic thrombocytopenic purpura: A report on 53 cases. Br J Haematol 74:223
Raife TJ, Olson JD, Lentz SR (1996) Platelet antibody testing in idiopathic thrombocytopenic purpura. Blood 89:1112–1114
Reiner A, Gernsheimer T, Slichter SJ (1995) Pulse cyclophosphamide therapy for refractory autoimmune thrombocytopenic purpura. Blood 85:351
Robb LG, Tiedeman K (1990) Idiopathic thrombocytopenic purpura: Predictors of chronic disease. Arch Dis Child 65:502
Salama A, Kiefel V, Mueller-Eckhardt C (1986) Effect of IgG anti Rho(D) in adult patients with chronic autoimmune thrombocytopenia. Am J Hematol 22:241–250
Saleh MN, Gutheil J, Moore M et al (2000) A pilot study of the anti-CD20 monoclonal antibody rituximab in patients with refractory immune thrombocytopenia. Semin Oncol 6(suppl 12):99–103
Samuelson A, Towers TL, Ravetch JV (2001) Anti-inflamatory Activity of IVIG Mediated Through the Inhibitory FC Receptor. Science 291:484–486
Sartorius JA (1984) Steroid treatment of idiopathic thrombocytopenic purpura in children. Preliminary results of a randomized cooperative study. Am J Pediatr Hematol Oncol 6:165
Semple JW, Milev Y, Cosgrave D et al (1996) Differences in serum cytokine levels in acute and chronic autoimmune thrombocytopenic purpura: Relationship to platelet phenotype and antiplatelet T-Cell reactivity. Blood 87: 4245–4254
Stasi R, Pagana A, Stipa E et al (2001) Rituximab chimeric anti-CD20 monoclonal antibody treatment for adults with chronic idiopathic thrombocytopenic purpura. Blood 98:952–957
Semple JW, Freedman J (1995) Abnormal cellular immune mechanisms associated with autoimmune thrombocytopenia. Trans Med Reviews 4:327–338
Styrt B (1990) Infection associated with asplenia: Risks, mechanisms, and prevention. Am J Med 88:5–33
Tamary H, Kaplinsky C, Levy I et al (1994) Chronic childhood idiopathic thrombocytopenic purpura; Longterm follow-up. Acta Paediatr 83:931
Van der Beek-Boter JW, Van Oers MHJ, Von dem Borne AEKG et al (1992) Ascorbate for the treatment of ITP. Eur J Haematol 48:61
Van Leeuwen EF, van der Ven JTH, Engelfriet CP et al (1982) Specificity of autoantibodies in autoimmune thrombocytopenia. Blood 59:23–26
Warner MN, Moore JC, Warkentin TE et al (1999) A prospective study of protein-specific assays used to investigate idiopathic thrombocytopenic purpura. Br J Haemat 104:442–447
Weinblatt ME, Kochen J, Ortega J (1988) Danazol for children with immune thrombocytopenic purpura. Am J Dis Child 142:1317
Yu MW, Mason BL, Guo ZP et al (1995) Hepatitis C transmission associated with intravenous immunoglobulins. Lancet 345:1173
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Imbach, P., Kühne, T., Gaedicke, G. (2006). Idiopathische thrombozytopenische Purpura. In: Gadner, H., Gaedicke, G., Niemeyer, C., Ritter, J. (eds) Pädiatrische Hämatologie und Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29036-2_35
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DOI: https://doi.org/10.1007/3-540-29036-2_35
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