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Chromatin Mechanisms in Drosophila Dosage Compensation

  • Chapter
Epigenetics and Chromatin

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 38))

Abstract

Dosage compensation ensures that males and females equalize the expression of the X-linked genes and therefore provides an exquisite model system to study chromosome-wide transcription regulation. In Drosophila, this is achieved by hyper-transcription of the genes on the male X chromosome. This process requires an RNA/protein-containing dosage compensation complex. Here, we discuss the current status of the known Drosophila complex members as well as the recent views on targeting, assembly and spreading mechanisms.

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  1. European Molecular Biology Laboratory, Gene Expression Programme, Meyerhofstrasse 1, 69117, Heidelberg, Germany

    Mikko Taipale & Asifa Akhtar

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  1. Mikko Taipale
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  2. Asifa Akhtar
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  1. Institute of Molecular Genetics of Montpellier, 1919 Route de Mende, 34293, Montpellier Cedex 05, France

    Philippe Jeanteur

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Taipale, M., Akhtar, A. (2005). Chromatin Mechanisms in Drosophila Dosage Compensation. In: Jeanteur, P. (eds) Epigenetics and Chromatin. Progress in Molecular and Subcellular Biology, vol 38. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27310-7_5

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