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Application of Aptamers in Therapeutics and for Small-Molecule Detection

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RNA Towards Medicine

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 173))

Abstract

Nucleic acids that can bind with high affinity and specificity to target molecules are called “aptamers”. Aptamers recognise a large variety of different enzymatic methods. molecule classes. The main focus of this chapter is small molecules as targets. Aptamers are applied complementarily to antibody technologies and can substitute antibodies or small molecules wherever their different properties, such as biochemical nature or highly discriminating capacities, are advantageous. Examples of promising applications of these versatile molecules are discussed in the field of therapeutics and biotechnology with a special view to small-molecule detection.

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Authors and Affiliations

  1. RiNA Netzwerk RNA-Technologien GmbH, Takustr. 3, 14195, Berlin, Germany

    M. Menger, J. Glökler & M. Rimmele

Authors
  1. M. Menger
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  2. J. Glökler
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  3. M. Rimmele
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Editor information

Editors and Affiliations

  1. Institute of Chemistry/Biochemistry, Free University Berlin, Thielallee 63, 14195, Berlin, Germany

    Volker Erdmann

  2. Institute of Bioorganic Chemistry, Polish Academy of Scienes, Noskowskiego 12/14, 61-704, Poznan, Poland

    Jan Barciszewski

  3. Institute of Experimental Pathology, Molecular Neurobiology (ZMBE), University of Münster, Von-Esmarch-Str. 56, 48149, Münster, Germany

    Jürgen Brosius

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Menger, M., Glökler, J., Rimmele, M. (2006). Application of Aptamers in Therapeutics and for Small-Molecule Detection. In: Erdmann, V., Barciszewski, J., Brosius, J. (eds) RNA Towards Medicine. Handbook of Experimental Pharmacology, vol 173. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27262-3_18

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