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Endometrial Morphology and Progestogens

  • Conference paper
New Mechanisms for Tissue-Selective Estrogen-Free Contraception

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 52))

4.16 Conclusion

There is a large body of knowledge about the local morphological and functional effects on the endometrium with progestogen exposure. This review has particularly focused on the effects of intrauterine LNG administration. It is disappointing that to date no single factor has emerged that directly correlates with the aberrant endometrial bleeding associated with any of the methods of progestogenonly contraception. It is therefore probable that several factors acting closely together will contribute to the pathogenesis of these abnormal bleeding patterns experienced by women. The eventual elucidation of such factors will facilitate the development of intervention strategies designed to overcome the BTB experienced with progestogen-only contraception. Thereafter progestogen-only contraceptive methods will gain increased user satisfaction and women may benefit from other health gains, especially if the progestogen is delivered locally to the uterine cavity.

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Authors and Affiliations

  1. Reproductive and Developmental Sciences, Obstetrics and Gynaecology, The University of Edinburgh, Chancellor’s Building 49 Little, France Crescent, EH 16 4SB, Edinburgh, UK

    H. O. D. Critchley

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  1. H. O. D. Critchley
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Editors and Affiliations

  1. Instituto Chileno de Medicina Reproductive (ICMER), José Ramon Gutierrez 295, Santiago de Chile, Chile

    H. B. Croxatto

  2. Strategic Business Unit, Gynecology and Andrology, Schering AG, Müllerstr. 178, 13342, Berlin, Germany

    R. Schürmann  & I. Schellschmidt  & 

  3. CRBA, Gynecology and Andrology, Female Health Care, Schering AG, Müllerstr. 178, 13342, Berlin, Germany

    U. Fuhrmann

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© 2005 Springer-Verlag Berlin Heidelberg

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Critchley, H.O.D. (2005). Endometrial Morphology and Progestogens. In: Croxatto, H.B., Schürmann, R., Fuhrmann, U., Schellschmidt, I. (eds) New Mechanisms for Tissue-Selective Estrogen-Free Contraception. Ernst Schering Research Foundation Workshop, vol 52. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-27147-3_4

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  • DOI: https://doi.org/10.1007/3-540-27147-3_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-23089-2

  • Online ISBN: 978-3-540-27147-5

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