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Brix G, Semmler W, Port R, Schad LR, Layer G, Lorenz WJ (1991) Pharmacokinetic parameters in CNS Gd-DTPA enhanced MR imaging. J Comput Assist Tomogr 15:621–628
Buckley DL (2002) Uncertainty in the analysis of tracer kinetics using dynamic contrast-enhanced T1-weighted MRI. Magnetic Resonance in Medicine 47(3):601–606
Buckley DL, Roberts C, Parker GJ, Logue JP, Hutchinson CH (2003) In vivo determination of the microvascular characteristics of prostate cancer using dynamic contrast-enhanced MRI. 11th Meeting of the International Society for Magnetic Resonance in Medicine:461
Crone C (1963) The permeability of capillaries in various organs as determined by use of the ‘indicator diffusion’ method. Acta Physiol Scand 58:292–305
Daldrup HE, Shames DM, Husseini W, Wendland MF, Okuhata Y, Brasch RC (1998) Quantification of the extraction fraction for gadopentetate across breast cancer capillaries. Magn Reson Med 40:537–543
Degani H, Gusis V, Weinstein D, Fields S, Strano S (1997) Mapping pathophysiological features of breast tumors by MRI at high spatial resolution. Nat Med 3:780–782
Evelhoch JL (1999) Key factors in the acquisition of contrast kinetic data for oncology. J Magn Reson Imaging 10:254–259
Evelhoch JL, LoRusso P, DelProposto Z, Stark K, Latif Z, Morton P, Waterton J, Wheeler C, Barge A (2002) Dynamic contrast-enhanced MRI evaluation of the effects of ZD6126 on tumour vasculature in a phase I clinical trial. Proceedings of the Annual Meeting of the ISMRM:2095
Folkman J (1990) What is the evidence that tumors are angiogenesis dependent?. J Natl Cancer Inst 82:4–6
Folkman J (1995) Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1:27–31
Fritz-Hansen T, Rostrup E, Søndergaard L, Ring PB, Amtorp O, Larsson HB (1998) Capillary transfer constant of Gd-DTPA in the myocardium at rest and during vasodilation assessed by MRI. Magn Reson Med 40:922–929
Hatabu H, Tadamura E, Levin DL, Chen Q, Li W, Kim D, Prasad PV, Edelman RR (1999) Quantitative assessment of pulmonary perfusion with dynamic contrast-enhanced MRI. Magn Reson Med 42:1033–1038
Hayes C, Padhani AR, Leach MO (2002) Assessing changes in tumour vascular function using dynamic contrast-enhanced magnetic resonance imaging. NMR Biomed 15:154–163
Henderson E, Rutt BK, Lee TY (1998) Temporal sampling requirements for the tracer kinetics modeling of breast disease. Magn Reson Imaging 16:1057–1073
Henderson E, Sykes J, Drost D, Weinmann HJ, Rutt BK, Lee TY (2000) Simultaneous MRI measurement of blood flow, blood volume, and capillary permeability in mammary tumors using two different contrast agents. J Magn Reson Imaging 12:991–1003
Jackson A, Haroon H, Zhu XP, Li KL, Thacker NA, Jayson G (2002) Breath-hold perfusion and permeability mapping of hepatic malignancies using magnetic resonance imaging and a first-pass leakage profile model. NMR Biomed 15:164–173
Johnson JA, Wilson TA (1966) A model for capillary exchange. Am J Physiol 210:1299–1303
Kety SS (1951) The theory and applications of the exchange of inert gas at the lungs and tissues. Pharmacol Rev 3:1–41
Koh TS, Zeman V, Darko J, Lee TY, Milosevic MF, Haider M, Warde P, Yeung IW (2001) The inclusion of capillary distribution in the adiabatic tissue homogeneity model of blood flow. Phys Med Biol 46:1519–1538
Larsson HBW, Stubgaard M, Fredricksen JL, Jensen M, Henriksen O, Paulson OB (1990) Quantitation of blood-brain barrier defect by magnetic resonance imaging and gadolinium-DTPA in patients with multiple sclerosis and brain lesions. Magnetic Resonance in Medicine 16:117–131
Li KL, Zhu XP, Waterton J, Jackson A (2000) Improved 3D quantitative mapping of blood volume and endothelial permeability in brain tumors. J Magn Reson Imaging 12:347–357
Liney GP, Gibbs P, Hayes C, Leach MO, Turnbull LW (1999) Dynamic contrast-enhanced MRI in the differentiation of breast tumors: user-defined versus semi-automated region-of-interest analysis. J Magn Reson Imaging 10(6):945–949
Mattiello, J and Evelhoch JL (1991) Relative volume-average murine tumor blood flow measurement via deuterium nuclear magnetic resonance spectroscopy. Magn Reson Med 18(2):320–334
Mayr NA, Yuh WT, Arnholt JC, Ehrhardt JC, Sorosky JI, Magnotta VA, Berbaum KS, Zhen W, Paulino AC, Oberley LW, Sood AK, Buatti JM (2000) Pixel analysis of MR perfusion imaging in predicting radiation therapy outcome in cervical cancer. J Magn Reson Imaging 12:1027–1033
Mitchell DG (1997) MR imaging contrast agents—what's in a name?. J Magn Reson Imaging 7:1–4
Ohno Y, Hatabu H, Higashimo T, Takenaka D, Watanabe H, Nishimura Y, Yoshimura M, Sugimura K (2004) Dynamic perfusion MRI versus perfusion scintigraphy: prediction of postoperative lung function in patients with lung cancer. American Journal of Roentgenology 182:73–78
Parker GJM (1997) Monitoring contrast agent kinetics using dynamic MRI: Quantitative and qualitative analysis. Institute of Cancer Research
Parker GJM, Tanner SF, Leach MO (1996) Pitfalls in the measurement of tissue permeability over short time-scales using multi-compartment models with a low temporal resolution blood input function. 4th Meeting of the International Society for Magnetic Resonance in Medicine: 1582
Parker GJ, Clark D, Watson Y, Buckley DL, Berrisford C, Anderson H, Jackson A, Waterton JC (2003) T1-weighted DCE-MRI applied to lung tumours: Pre-processing and modelling. 11th Meeting of the International Society for Magnetic Resonance in Medicine:1255
Parker GJ, Jackson A, Waterton JC, Buckley DL (2003) Automated arterial input function extraction for T1-weighted DCE-MRI. 11th Meeting of the International Society for Magnetic Resonance in Medicine:1264
Patlak CS, Blasberg RG, Fenstermacher JD (1983) Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 3:1–7
Renkin EM (1959) Transport of potassium-42 from blood to tissue in isolated mammalian skeletal muscles. Am J Physiol 197:1205–1210
Roberts TP (1997) Physiologic measurements by contrast-enhanced MR imaging: expectations and limitations. J Magn Reson Imaging 7:82–90
Sha'afi RI (1981) Permeability for water and other polar molecules. Membrane Transport:29–60
St Lawrence KS, Lee T-Y (1998) An adiabatic approximation to the tissue homogeneity model for water exchange in the brain: 1. Theoretical derivation. J Cereb Blood Flow Metab 18:1365–1377
Su MY, Jao JC, Nalcioglu O (1994) Measurement of vascular volume fraction and blood-tissue permeability constants with a pharmacokinetic model: studies in rat muscle tumors with dynamic Gd-DTPA enhanced MRI. Magn Reson Med 32:714–724
Tofts PS (1997) Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. J Magn Reson Imaging 7:91–101
Tofts PS, Kermode AG (1991) Measurement of the blood-brain barrier permeability and leakage space using dynamic MR imaging. 1. Fundamental concepts. Magn Reson Med 17:357–367
Tofts PS, Berkowitz B, Schnall MD (1995) Quantitative analysis of dynamic Gd-DTPA enhancement in breast tumors using a permeability model. Magn Reson Med 33:564–568
Tofts PS, Brix G, Buckley DL, Evelhoch JL, Henderson E, Knopp MV, Larsson HBW, Lee T-Y, Mayr NA, Parker GJM, Port RE, Taylor J, Weisskoff RM (1999) Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging 10(3):223–232
Vonken EP, van Osch MJ, Bakker CJ, Viergever MA (2000) Simultaneous quantitative cerebral perfusion and Gd-DTPA extravasation measurement with dual-echo dynamic susceptibility contrast MRI. Magn Reson Med 43:820–827
Weinmann H-J, Laniado M, Mützel W (1984) Pharmacokinetics of GdDTPA/dimeglumine after intravenous injection into healthy volunteers. Physiol Chem Phys Med NMR 16:167–172
Zierler KL (1963) Theory of use of indicators to measure blood flow and extracellular volume and calculation of transcapillary movement of tracers. Circulation Research 7:464–471
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Parker, G.J.M., Buckley, D.L. (2005). Tracer Kinetic Modelling for T1-Weighted DCE-MRI. In: Jackson, A., Buckley, D.L., Parker, G.J.M. (eds) Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Oncology. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26420-5_6
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DOI: https://doi.org/10.1007/3-540-26420-5_6
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