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Measuring Contrast Agent Concentration in T1-Weighted Dynamic Contrast-Enhanced MRI

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Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Oncology

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

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References

  • Barsky D, Putz B, Schulten K (1997) Theory of heterogeneous relaxation in compartmentalized tissues. Magn Reson Med 37:666–675

    PubMed  Google Scholar 

  • Bluml S, Schad LR, Stepanow B, Lorenz WJ (1993) Spin-lattice relaxation-time measurement by means of a turboFLASH technique. Magn Reson Med, 30:289–295

    PubMed  Google Scholar 

  • Boetes C, Barentsz JO, Mus RD, van der Sluis RF, van Erning LJ, Hendriks JH, Holland R, Ruys SH (1994) MR characterization of suspicious breast lesions with a gadolinium-enhanced turboFLASH subtraction technique. Radiology 193:777–781

    PubMed  Google Scholar 

  • Brookes JA, Redpath TW, Gilbert FJ, Murray AD, Staff RT (1999) Accuracy of T1 measurement in dynamic contrastenhanced breast MRI using two-and three-dimensional variable flip angle fast low-angle shot. J Magn Reson Imaging 9:163–171

    Article  PubMed  Google Scholar 

  • Buckley DL (2002) Uncertainty in the analysis of tracer kinetics using dynamic contrast-enhanced T1-weighted MRI. Magn Reson Med 47:601–606

    Article  PubMed  Google Scholar 

  • Calamante F, Gadian DG, Connelly A (2000) Delay and dispersion effects in dynamic susceptibility contrast MRI: simulations using singular value decomposition. Magn Reson Med 44:464–473

    Article  Google Scholar 

  • Checkley D, Tessier JJ, Wedge SR, Dukes M, Kendrew J, Curry B, Middleton B, Waterton JC (2003) Dynamic contrastenhanced MRI of vascular changes induced by the VEGF-signalling inhibitor ZD4190 in human tumour xenografts. Magn Reson Imaging 21:475–482

    Google Scholar 

  • Cron GO, Santyr G, Kelcz F (1999) Accurate and rapid quantitative dynamic contrast-enhanced breast MR imaging using spoiled gradient-recalled echoes and bookend T-1 measurements. Magn Reson Med 42:746–753

    Article  PubMed  Google Scholar 

  • Donahue KM, Burstein D, Manning WJ, Gray ML (1994) Studies of Gd-DTPA relaxivity and proton-exchange rates in tissue. Magn Reson Med 32:66–76

    PubMed  Google Scholar 

  • Donahue KM, Weisskoff RM, Chesler DA, Kwong KK, Bogdanov AA Jr, Mandeville JB, Rosen BR (1996) Improving MR quantification of regional blood volume with intravascular T1 contrast agents: accuracy, precision, and water exchange. Magn Reson Med 36:858–867

    PubMed  Google Scholar 

  • Donahue KM, Weisskoff RM, Burstein D (1997) Water diffusion and exchange as they influence contrast enhancement. J Magn Reson Imaging 7:102–110

    PubMed  Google Scholar 

  • Engelstad BL, Wolf GL (1988) Contrast agents. In: Stark DD, Bradley WG Jr (eds) Magnetic resonance imaging. Mosby, St Louis, pp 161–181

    Google Scholar 

  • Evelhoch JL (1999) Key factors in the acquisition of contrast kinetic data for oncology. J Magn Reson Imaging 10:254–259

    Article  PubMed  Google Scholar 

  • Fram EK, Herfkens RJ, Johnson GA, Glover GH, Karis JP, Shimakawa A, Perkins TG, Pelc NJ (1987) Rapid calculation of T1 using variable flip angle gradient refocused imaging. Magn Reson Imaging 5:201–208

    Article  PubMed  Google Scholar 

  • Freeman A, Gowland P, Jellineck D, Wilcock D, Firth J, Worthington B, Mansfield P, Ratcliffe G (1994) Gd uptake in brain tumours: application of fast T1 mapping using LL_EPI (abstract). Proceedings of the Society of Magnetic Resonance, San Francisco, CA p 863

    Google Scholar 

  • Fritz-Hansen T, Rostrup E, Larsson HB, Sondergaard L, Ring P, Henriksen O (1996) Measurement of the arterial concentration of Gd-DTPA using MRI: a step toward quantitative perfusion imaging. Magn Reson Med 36:225–231

    PubMed  Google Scholar 

  • Gowland P, Mansfield P (1993) Accurate measurement of T(1) in-vivo in less-than 3 seconds using echo-planar imaging. Magn Reson Med 30:351–354

    PubMed  Google Scholar 

  • Gowland P, Mansfield P, Bullock P, Stehling M, Worthington B, Firth J (1992) Dynamic studies of gadolinium uptake in brain tumors using inversion-recovery echo-planar imaging. Magn Reson Med 26:241–258

    PubMed  Google Scholar 

  • Haase A, Frahm J, Matthaei D, Hanicke W, Merboldt KD (1986) FLASH imaging-rapid NMR imaging using low flip-angle pulses. J Magn Reson 67:258–266

    Google Scholar 

  • Hayes C, Padhani AR, Leach MO (2002) Assessing changes in tumour vascular function using dynamic contrast-enhanced magnetic resonance imaging. NMR Biomed 15:154–163

    Article  PubMed  Google Scholar 

  • Hazlewood CF, Chang DC, Nichols BL, Woessner DE (1974) Nuclear magnetic resonance transverse relaxation times of water protons in skeletal muscle. Biophys J 14:583–606

    PubMed  Google Scholar 

  • Henderson E, Rutt BK, Lee TY (1998) Temporal sampling requirements for the tracer kinetics modeling of breast disease. Magn Reson Imaging 16:1057–1073

    PubMed  Google Scholar 

  • Heywang SH, Wolf A, Pruss E, Hilbertz T, Eiermann W, Permanetter W (1989) MR imaging of the breast with Gd-DTPA: use and limitations. Radiology 171:95–103

    PubMed  Google Scholar 

  • Hittmair K, Gomiscek G, Langenberger K, Recht M, Imhof H, Kramer J (1994) Method for the quantitative assessment of contrast agent uptake in dynamic contrast-enhanced MRI. Magn Reson Med 31:567–571

    PubMed  Google Scholar 

  • Judd RM, Atalay MK, Rottman GA, Zerhouni EA (1995) Effects of myocardial water exchange on T1 enhancement during bolus administration of MR contrast agents. Magn Reson Med 33:215–223

    PubMed  Google Scholar 

  • Judd RM, Reeder SB, May-Newman K (1999) Effects of water exchange on the measurement of myocardial perfusion using paramagnetic contrast agents. Magn Reson Med 41:334–342

    Article  PubMed  Google Scholar 

  • Landis CS, Li X, Telang FW, Molina PE, Palyka I, Vetek G, Springer CS (1999) Equilibrium transcytolemmal water-exchange kinetics in skeletal muscle in vivo. Magn Reson Med 42:467–478

    Article  PubMed  Google Scholar 

  • Landis CS, Li X, Telang FW, Coderre JA, Micca PL, Rooney WD, Latour LL, Vetek G, Palyka I, Springer CS (2000) Determination of the MRI contrast agent concentration time course in vivo following bolus injection: effect of equilibrium transcytolemmal water exchange. Magn Reson Med 44:563–574

    PubMed  Google Scholar 

  • Larsson HBW, Stubgaard M, Frederiksen JL, Jensen M, Henriksen O, Paulson OB (1990) Quantitation of blood-brain barrier defect by magnetic resonance imaging and gadolinium-DTPA in patients with multiple sclerosis and brain tumors. Magn Reson Med 16:117–131

    PubMed  Google Scholar 

  • Larsson HBW, Rosenbaum S, Fritz-Hansen T (2001) Quantification of the effect of water exchange in dynamic contrast MRI perfusion measurements in the brain and heart. Magn Reson Med 46:272–281

    Article  PubMed  Google Scholar 

  • Li KL, Zhu XP, Waterton J, Jackson A (2000) Improved 3D quantitative mapping of blood volume and endothelial permeability in brain tumors. J Magn Reson Imaging 12:347–357

    Article  PubMed  Google Scholar 

  • Mussurakis S, Buckley DL, Drew PJ, Fox JN, Carleton PJ, Turnbull LW, Horsman A (1997) Dynamic MR imaging of the breast combined with analysis of contrast agent kinetics in the differentiation of primary breast tumours. Clin Radiol 52:516–526

    PubMed  Google Scholar 

  • Mussurakis S, Gibbs P, Horsman A (1998) Peripheral enhancement and spatial contrast uptake heterogeneity of primary breast tumours: quantitative assessment with dynamic MRI. J Comput Assist Tomogr 22:35–46

    PubMed  Google Scholar 

  • Parker GJ, Suckling J, Tanner SF, Padhani AR, Revell PB, Husband JE, Leach MO (1997) Probing tumor microvascularity by measurement, analysis and display of contrast agent uptake kinetics. J Magn Reson Imaging 7:564–574

    PubMed  Google Scholar 

  • Parker GJ, Baustert I, Tanner SF, Leach MO (2000) Improving image quality and T-1 measurements using saturation recovery turboFLASH with an approximate K-space normalisation filter. Magn Reson Imaging 18:157–167

    Article  PubMed  Google Scholar 

  • Parker GJ, Barker GJ, Tofts PS (2001) Accurate multislice gradient echo T(1) measurement in the presence of non-ideal RF pulse shape and RF field nonuniformity. Magn Reson Med 45:838–845

    Article  PubMed  Google Scholar 

  • Parker GJ, Jackson A, Waterton JC, Buckley DL (2003) Automated arterial input function extraction for T1-weighted DCE-MRI (abstract). Proc ISMRM 11th annual meeting, Toronto, Canada, p 1264

    Google Scholar 

  • Pedevilla M, Stollberger R, Schmidt F, Wach P, Ebner F (1995) Comparison of various methods used for breast tumor characterization in Gd-DTPA enhanced MR imaging (abstract). Proc Society of Magnetic Resonance, Nice, France, p 1600

    Google Scholar 

  • Pfeuffer J, Flogel U, Dreher W, Leibfritz D (1998) Restricted diffusion and exchange of intracellular water: theoretical modelling and diffusion time dependence of H-1 NMR measurements on perfused glial cells. NMR Biomed 11:19–31

    Article  PubMed  Google Scholar 

  • Pirkle JL, Ashley DL, Goldstein JH (1979) Pulse nuclear magnetic resonance measurements of water exchange across the erythrocyte membrane employing a low Mn concentration. Biophys J 25:389–406

    PubMed  Google Scholar 

  • Quirk JD, Bretthorst GL, Duong TQ, Snyder AZ, Springer CS, Ackerman JJH, Neil JJ (2003) Equilibrium water exchange between the intra-and extracellular spaces of mammalian brain. Magn Reson Med 50:493–499

    Article  PubMed  Google Scholar 

  • Rijpkema M, Kaanders J, Joosten FBM, van der Kogel AJ, Heerschap A (2001) Method for quantitative mapping of dynamic MRI contrast agent uptake in human tumors. J Magn Reson Imaging 14:457–463

    Article  PubMed  Google Scholar 

  • Rosen BR, Belliveau JW, Vevea JM, Brady TJ (1990) Perfusion imaging with NMR contrast agents. Magn Reson Med 14:249–265

    PubMed  Google Scholar 

  • Shames DM, Kuwatsuru R, Vexler V, Muhler A, Brasch RC (1993) Measurement of capillary-permeability to macromolecules by dynamic magnetic resonance imaging: a quantitative noninvasive technique. Magn Reson Med 29:616–622

    PubMed  Google Scholar 

  • Springer CS Jr (1994) Physiochemical principles influencing magnetopharmaceuticals. In: Gillies RJ (ed) NMR in physiology and biomedicine. Academic Press, San Diego, pp 75–100

    Google Scholar 

  • Stanisz GJ, Henkelman RM (2000) Gd-DTPA relaxivity depends on macromolecular content. Magn Reson Med 44:665–667

    Article  PubMed  Google Scholar 

  • Terada T, Nambu K, Hyotani G, Miyamoto K, Tsuura M, Nakamura Y, Nishiguchi T, Itakura T, Hayashi S, Komai N (1992) A method for quantitative measurement of cerebral vascular-permeability using X-ray CT and iodinated contrastmedium. Neuroradiology 34:290–296

    Article  PubMed  Google Scholar 

  • Tofts PS, Kermode AG (1991) Measurement of the blood-brain barrier permeability and leakage space using dynamic MR imaging. 1. Fundamental concepts. Magn Reson Med 17:357–367

    PubMed  Google Scholar 

  • Tong CY, Prato FS (1994) A novel fast T1-mapping method. J Magn Reson Imaging 4:701–708

    PubMed  Google Scholar 

  • Vallee JP, Ivancevic M, Lazeyras F, Kasuboski L, Chatelain P, Righetti A, Didier D (2003) Use of high flip angle in T1-prepared FAST sequences for myocardial perfusion quantification. Eur Radiol 13:507–514

    PubMed  Google Scholar 

  • Wang HZ, Riederer SJ, Lee JN (1987) Optimizing the precision in T1 relaxation estimation using limited flip angles. Magn Reson Med 5:399–416

    PubMed  Google Scholar 

  • Wedeking P, Sotak CH, Telser J, Kumar K, Chang CA, Tweedle MF (1992) Quantitative dependence of MR signal intensity on tissue concentration of Gd(HP-DO3A) in the nephrectomized rat. Magn Reson Imaging 10:97–108

    Article  PubMed  Google Scholar 

  • Yankeelov TE, Rooney WD, Li X, Springer CS (2003) Variation of the relaxographic „shutter-speed“ for transcytolemmal water exchange affects the CR bolus-tracking curve shape. Magn Reson Med 50:1151–1169

    Article  PubMed  Google Scholar 

  • Zhu XP, Li KL, Kamaly-Asl ID, Checkley DR, Tessier JJ, Waterton JC, Jackson A (2000) Quantification of endothelial permeability, leakage space, and blood volume in brain tumors using combined T1 and T2* contrast-enhanced dynamic MR imaging. J Magn Reson Imaging 11:575–585

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Imaging Science and Biomedical Engineering, University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, UK

    Geoffrey J. M. Parker PhD

Authors
  1. 1David L. Buckley PhD
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  2. Geoffrey J. M. Parker PhD
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Editor information

Editors and Affiliations

  1. Imaging Science and Biomedical Engineering, The Medical School, University of Manchester, Stopford Building Oxford Road, Manchester, M13 9PT, UK

    Alan Jackson MBChB (Hons), PhD, FRCP FRCR (Professor) (Professor)

  2. Imaging Science and Biomedical Engineering, University of Manchester, Stopford Building Oxford Road, Manchester, M13 9PT, UK

    David L. Buckley PhD (Lecturer in Image Science) & Geoffrey J. M. Parker PhD (Research Fellow in Imaging Science) (Lecturer in Image Science) &  (Research Fellow in Imaging Science)

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© 2005 Springer-Verlag Berlin Heidelberg

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Buckley, 1.L., Parker, G.J.M. (2005). Measuring Contrast Agent Concentration in T1-Weighted Dynamic Contrast-Enhanced MRI. In: Jackson, A., Buckley, D.L., Parker, G.J.M. (eds) Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Oncology. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26420-5_5

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  • DOI: https://doi.org/10.1007/3-540-26420-5_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-42322-5

  • Online ISBN: 978-3-540-26420-0

  • eBook Packages: MedicineMedicine (R0)

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