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Ozone chemonucleolysis in non-contained lumbar disc herniations

A pilot study with 12 months follow-up

  • Conference paper
Advanced Peripheral Nerve Surgery and Minimal Invasive Spinal Surgery

Part of the book series: Acta Neurochirurgica ((NEUROCHIRURGICA,volume 97))

Summary

Study design. Prospective case series with six and twelve months follow up.

Objective. To observe clinical and morphological results of the intradiscal ozone chemionucleolysis in patients affected by non-contained lumbar disc herniations.

Methods. 30 patients were included in the study on the base of precise inclusion and exclusion criteria. The patients were followed on 6 and 12 months period by Visual Analogic Scale (VAS), Roland Morris Disability Questionnaire (RMDQ) and Overall Patient Rating Scale (OPRS). Disc herniation volume morphology was evaluated at 5 months by control MRI scanning.

Results. Twenty-seven patients (90%) showed a statistically significant improvement in pain (P < 0.001, Wilcoxon test) and function (P < 0.001, Wilcoxon test), on VAS and RMDQ evaluation, respectively. The mean satisfaction with the treatment on OPSR was 79.3%, with 24 patients referring satisfaction equal or greater than 80%. There were no major complications related to the procedure.

Conclusions. The results of this study indicate the ozone chemonucleolysis as a possibly effective modality of treatment in patients affected by signs and symptoms of non-contained lumbar disc herniations that have overpassed conservative measures and have not yet fulfilled the indications for open surgical treatment.

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Authors and Affiliations

  1. Unità Funzionale di Chirurgia Spinale c.d.c. Villanova, Florence, Italy

    Josip Buric M.D.

  2. Don Gnocchi Foundation, Florence, Italy

    R. Molino Lova

Authors
  1. Josip Buric M.D.
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  2. R. Molino Lova
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Corresponding author

Correspondence to Josip Buric M.D. .

Editor information

Editors and Affiliations

  1. EU.N.I. European Neurosurgical Institute, Treviso, Italy

    Alberto Alexandre

  2. Neurosurgical Department, Verona University, Verona, Italy

    Albino Bricolo

  3. Boltzmann Institut für Experimentelle Plastische Chirurgie, University of Vienna, Austria

    Hanno Millesi

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© 2005 Springer-Verlag

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Buric, J., Lova, R.M. (2005). Ozone chemonucleolysis in non-contained lumbar disc herniations. In: Alexandre, A., Bricolo, A., Millesi, H. (eds) Advanced Peripheral Nerve Surgery and Minimal Invasive Spinal Surgery. Acta Neurochirurgica, vol 97. Springer, Vienna. https://doi.org/10.1007/3-211-27458-8_20

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  • DOI: https://doi.org/10.1007/3-211-27458-8_20

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-23368-9

  • Online ISBN: 978-3-211-27458-3

  • eBook Packages: MedicineMedicine (R0)

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