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Gadolinium Chelates and Stability

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Contrast Media

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

Abstract

The gadolinium ions which enhance the signals in MR images are very toxic, so in the contrast medium molecule they have to be strongly attached to a chelate to avoid adverse effects. The linear chelate molecules are open chains which can fold and unfold off the gadolinium ion with ease. In contrast, the macrocyclic chelate molecules are rigid rings of almost optimal size to cage the gadolinium ion. Experimental data, both in vitro and in vivo, and clinical observations, have confirmed the lower stability of the linear gadolinium-based molecules compared to the more stable macrocyclic agents.

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Authors and Affiliations

  1. Diagnostic Imaging, University of Sheffield, Sheffield, S36 2TS, UK

    Sameh K. Morcos

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  1. Sameh K. Morcos
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Correspondence to Sameh K. Morcos .

Editor information

Editors and Affiliations

  1. Copenhagen University Hospital, Herlev, Denmark

    Henrik S. Thomsen

  2. Diagnostic Radiology Dept., St. Bartholomews Hospital, London, United Kingdom

    Judith A. W. Webb

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© 2014 Springer-Verlag Berlin Heidelberg

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Morcos, S.K. (2014). Gadolinium Chelates and Stability. In: Thomsen, H., Webb, J. (eds) Contrast Media. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2013_895

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  • DOI: https://doi.org/10.1007/174_2013_895

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-36723-6

  • Online ISBN: 978-3-642-36724-3

  • eBook Packages: MedicineMedicine (R0)

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