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Nuclear Transcription Factors in the Mitochondria: A New Paradigm in Fine-Tuning Mitochondrial Metabolism

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Pharmacology of Mitochondria

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 240))

Abstract

Noncanonical functions of several nuclear transcription factors in the mitochondria have been gaining exceptional traction over the years. These transcription factors include nuclear hormone receptors like estrogen, glucocorticoid, and thyroid hormone receptors: p53, IRF3, STAT3, STAT5, CREB, NF-kB, and MEF-2D. Mitochondria-localized nuclear transcription factors regulate mitochondrial processes like apoptosis, respiration and mitochondrial transcription albeit being nuclear in origin and having nuclear functions. Hence, the cell permits these multi-stationed transcription factors to orchestrate and fine-tune cellular metabolism at various levels of operation. Despite their ubiquitous distribution in different subcompartments of mitochondria, their targeting mechanism is poorly understood. Here, we review the current status of mitochondria-localized transcription factors and discuss the possible targeting mechanism besides the functional interplay between these factors.

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Acknowledgments

We would like to thank all the members of Dr. Sepuri lab for critical comments on the manuscript. We are grateful to Dr. Thanuja Krishnamoorthy for critically evaluating the manuscript. We thank the funding agency SERB to Dr. Sepuri lab and DST-FIST and UGC-SAP to the department. Mr. Arun Kumar and Fareed Mohammed are supported by CSIR and UGC Junior Research Fellowship, respectively.

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  1. Department of Biochemistry, School of Life Sciences, University of Hyderabad, Telangana, 500046, India

    Naresh Babu V. Sepuri, Prasad Tammineni, Fareed Mohammed & Arunkumar Paripati

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  1. Naresh Babu V. Sepuri
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  2. Prasad Tammineni
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  3. Fareed Mohammed
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Correspondence to Naresh Babu V. Sepuri .

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  1. Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA

    Harpreet Singh

  2. Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

    Shey-Shing Sheu

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Sepuri, N.B.V., Tammineni, P., Mohammed, F., Paripati, A. (2016). Nuclear Transcription Factors in the Mitochondria: A New Paradigm in Fine-Tuning Mitochondrial Metabolism. In: Singh, H., Sheu, SS. (eds) Pharmacology of Mitochondria. Handbook of Experimental Pharmacology, vol 240. Springer, Cham. https://doi.org/10.1007/164_2016_3

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