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Extracellular Activities of Aminoacyl-tRNA Synthetases: New Mediators for Cell–Cell Communication

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Aminoacyl-tRNA Synthetases in Biology and Medicine

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 344))

Abstract

Over the last decade, many reports have discussed aminoacyl-tRNA synthetases (ARSs) in extracellular space. Now that so many of them are known to be secreted with distinct activities in the broad range of target cells including endothelial, various immune cells, and fibroblasts, they need to be classified as a new family of extracellular signal mediators. In this chapter the identity of the secreted ARSs, receptors, and their physiological and pathological implications will be described.

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Authors and Affiliations

  1. Medicinal Bioconvergence Research Center, Graduate School of Convergence Science and Technology, College of Pharmacy, Seoul National University, Seoul, 151-742, South Korea

    Sung Hwa Son, Min Chul Park & Sunghoon Kim

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  1. Sung Hwa Son
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  2. Min Chul Park
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  3. Sunghoon Kim
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Correspondence to Min Chul Park .

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  1. Department of Molecular Medicine and Biopharmaceutical Sciences, Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University, Korea, Republic of (South Korea)

    Sunghoon Kim

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Son, S.H., Park, M.C., Kim, S. (2013). Extracellular Activities of Aminoacyl-tRNA Synthetases: New Mediators for Cell–Cell Communication. In: Kim, S. (eds) Aminoacyl-tRNA Synthetases in Biology and Medicine. Topics in Current Chemistry, vol 344. Springer, Dordrecht. https://doi.org/10.1007/128_2013_476

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