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Chiral Sensor Devices for Differentiation of Enantiomers

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Differentiation of Enantiomers II

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 341))

Abstract

Differentiation of enantiomers remains one of the most attractive and important research areas in analytical chemistry due to its impact on pharmaceutical, chemical, biotechnology, and food industries. For a long time chiral separation techniques, such as high performance liquid chromatography (HPLC), gas chromatography (GC), and capillary electrophoresis (CE), have represented the gold standard for the separation and determination of enantiomers. These techniques, besides being time consuming and expensive, are also not suitable for real time analysis. Therefore, the development of fast and reliable chiral sensors remains a challenge to achieve on-line analysis of enantiomers in both gas and liquid samples. The scope of this chapter is to provide an overview on the basic functioning principles, as well as on the performance level, of solid-state sensing devices for enantiomers differentiation. Particular attention is paid to work providing a set of analytical figures of merit (sensitivity, repeatability, reproducibility, limit-of-detection, etc.) as well as to studies involving miniaturized (or miniaturizable) analytical devices that can deliver real-time, on-line, and label-free information on chiral compounds.

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Abbreviations

AFM:

Atomic force microscopy

Ala:

Alanine

Apt:

Aptamer

APTES:

3-Aminopropyltriethoxysilane

Asp:

Aspartic acid

CD:

Cyclodextrins

CLEP:

Chiral ligand exchange potentiometry

CSA:

Camphor sulfonic acid

CV:

Cyclic voltammetry

Cy:

Cysteine

DOPA:

Dopamine

DPV:

Differential pulse voltammetry

EIS:

Electrochemical impedance spectroscopy

GC:

Gas chromatography

Glu:

Glutamic acid

GSA:

Goat serum albumin

Hcy:

Homocysteine

His:

Histidine

HSA:

Human serum albumin

ISE:

Ion-selective electrode

ISFET:

Ion-selective field effect transistor

ITO:

Indium tin oxide

MA:

Mandelic acid

MIP:

Molecular imprinted polymer

MPTMS:

(3-Mercaptopropyl)trimethoxysilane

OCD:

Optical circular dichroism

OFET:

Organic film effect transistor

OTS:

Octadecyltrichlorosilane

PDMS:

Polydimethylsiloxane

PET:

Polyethyleneterephthalate

PPE:

Poly(phenylenethynylene)

PPy:

Poly(pyrrole)

PVC:

Polyvinylchloride

QCM:

Quartz crystal microbalance

RbSA:

Rabbit serum albumin

SAM:

Self-assembled monolayer

Try:

Tryptophan

TSMR:

Thickness shear mode resonator

Tym:

Tyrosinamide

Tyr:

Tyrosine

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Authors and Affiliations

  1. Università degli Studi di Bari “A. Moro”, via Orabona, 4, 70125, Bari, Italy

    Kyriaki Manoli, Maria Magliulo & Luisa Torsi

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  1. Kyriaki Manoli
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  2. Maria Magliulo
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  3. Luisa Torsi
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Correspondence to Luisa Torsi .

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  1. Institute of Organic Chemistry, University of Tübingen, Tübingen, Germany

    Volker Schurig

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Manoli, K., Magliulo, M., Torsi, L. (2013). Chiral Sensor Devices for Differentiation of Enantiomers. In: Schurig, V. (eds) Differentiation of Enantiomers II. Topics in Current Chemistry, vol 341. Springer, Cham. https://doi.org/10.1007/128_2013_444

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