Abstract
Molecular imprinting is a process that allows for the synthesis of artificial receptors for a given target molecule based on synthetic polymers. The target molecule acts as a template around which interacting and cross-linking monomers are arranged and co-polymerized to form a cast-like shell. In essence, a molecular memory is imprinted in the polymer, which is now capable of selectively binding the target. Molecularly imprinted polymers (MIPs) thus possess the most important feature of biological antibodies - specific molecular recognition. They can thus be used in applications where selective binding events are of importance, such as immunoassays, affinity separation, biosensors, and directed synthesis and catalysis. Since its beginnings in the 1970s, the technique of molecular imprinting has greatly diversified during the last decade both from a materials point of view and from an application point of view. Still, there is much room for further improvement. The key challenges, in particular the binding site homogeneity and water compatibility of MIPs, and the possibility of synthesizing MIPs specific for proteins, are actively addressed by research groups over the World. Other important points are the conception of composite materials based on MIPs, in order to include additional interesting properties into the material, and the synthesis of very small and quasi-soluble MIPs, close in size to proteins.
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References
Arshady R, Mosbach K (1981) Makromol Chem 182:687
Wulff G, Sarhan A (1972) Angew Chem Int Ed 11:341
Haupt K (2003) Anal Chem 75:376A
Dickert FL, Hayden O, Halikias KP (2001) Analyst 126:766
Katz A, Davis ME (2000) Nature 403:286
Lordel S, Chapuis-Hugon F, Eudes V, Pichon V (2010) J Chromatogr A 1217:6674
Ansell RJ, Mosbach K (1998) Analyst 123:1611
Pérez N, Whitcombe MJ, Vulfson EN (2000) J Appl Polym Sci 77:1851
Bompart M, De Wilde Y, Haupt K (2009) Adv Mater 22:2343
Lakshmi D, Bossi A, Whitcombe MJ, Chianella I, Fowler SA, Subrahmanyam S, Piletska EV, Piletsky SA (2009) Anal Chem 81:3576
Umpleby RJ, Baxter SC, Chen Y, Shah RN, Shimizu KD (2001) Anal Chem 73:4584
Zimmerman SC, Lemcoff NG (2004) Chem Commun 1:5
Möller K, Crescenzi C, Nilsson U (2004) Anal Bioanal Chem 378:197
Wulff G, Knorr K (2002) Bioseparation 10:257
Shea KJ, Thompson EA (1978) J Org Chem 43:4253
Whitcombe MJ, Rodriguez ME, Villar P, Vulfson EN (1995) J Am Chem Soc 117:7105
Chianella I, Lotierzo M, Piletsky SA, Tothill IE, Chen B, Karim K, Turner APF (2002) Anal Chem 74:1288
Wu L, Li Y (2004) J Mol Recognit 17:567
Yañez F, Chianella I, Piletsky SA, Concheiro A, Alvarez-Lorenzo C (2010) Anal Chim Acta 659:178
O'Mahony J, Molinelli A, Nolan K, Smyth MR, Mizaikoff B (2005) Biosens Bioelectron 20:1884
Molinelli A, O'Mahony J, Nolan K, Smyth MR, Jakusch M, Mizaikoff B (2005) Anal Chem 77:5196
Hall AJ, Manesiotis P, Emgenbroich M, Quaglia M, De Lorenzi E, Sellergren B (2005) J Org Chem 70:1732
Ansell RJ, Wang DY, Kuah JKL (2008) Analyst 133:1673
Lanza F, Sellergren B (1999) Anal Chem 71:2092
Takeuchi T, Fukuma D, Matsui J (1999) Anal Chem 71:285
Takeuchi T, Seko A, Matsui J, Mukawa T (2001) Instrum Sci Technol 29:1
Dirion B, Cobb Z, Schillinger E, Andersson LI, Sellergren B (2003) J Am Chem Soc 125:15101
Ceolin G, Navarro-Villoslada F, Moreno-Bondi MC, Horvai G, Horvath V (2009) J Comb Chem 11:645
Navarro-Villoslada F, San Vicente B, Moreno-Bondi MC (2004) Anal Chim Acta 504:149
Navarro-Villoslada F, Takeuchi T (2005) Bull Chem Soc Jpn 78:1354
Rossi C, Haupt K (2007) Anal Bioanal Chem 389:455
Patel A, Fouace S, Steinke JHG (2003) Chem Commun 1:88
Patel A, Fouace S, Steinke JHG (2004) Anal Chim Acta 504:53
Bompart M, Haupt K (2009) Aust J Chem 62:751
Chiefari J, Chong YK, Ercole F, Krstina J, Jeffery J, Le TPT, Mayadunne RTA, Meijs GF, Moad CL, Moad G, Rizzardo E, Thang SH (1998) Macromolecules 31:5559
Moad G, Rizzardo E, Thang SH (2006) Aust J Chem 59:669
Titirici MM, Sellergren B (2006) Chem Mater 18:1773
Du Zhenxia I, Zhifeng F (2006) Chin Chem Lett 17:549
Southard GE, Van Houten KA, Ott EW, Murray GM (2007) Anal Chim Acta 581:202
Southard GE, Van Houten KA, Murray GM (2007) Macromolecules 40:1395
Liu H, Zhuang X, Turson M, Zhang M, Dong X (2008) J Sep Sci 31:1694
Gonzato C, Courty M, Pasetto P, Haupt K (2011) Adv Funct Mater 21:3947
Otsu T (2000) J Polym Sci Pol Chem 38:2121
Otsu T, Yoshida M, Tazaki T (1982) Makromol Chem Rapid Commun 3:133
Wang HY, Kobayashi T, Fujii N (1997) J Chem Technol Biotechnol 70:355
Rückert B, Hall A, Sellergren B (2002) J Mater Chem 12:2275
Sellergren B, Rückert B, Hall A (2002) Adv Mater 14:1204
Rong F, Feng X, Li P, Yuan C, Fu D (2006) Chinese Sci Bull 51:2566
Pérez-Moral N, Mayes AG (2007) Macromol Rapid Commun 28:2170
Vaughan AD, Sizemore SP, Byrne ME (2007) Polymer 48:74
Su S, Zhang M, Li B, Zhang H, Dong X (2008) Talanta 76:1141
Kamigaito M, Ando T, Sawamoto M (2001) Chem Rev 101:3689
Kato M, Kamigaito M, Sawamoto M, Higashimura T (1995) Macromolecules 28:1721
Wang J-S, Matyjaszewski K (1995) J Am Chem Soc 117:5614
Matyjaszewski K, Xia J (2001) Chem Rev 101:2921
Salomon DH, Rizzardo E, Cacioli P (1985) US Patent US4581429
Hawker CJ, Bosman AW, Harth E (2001) Chem Rev 101:3661
Boonpangrak S, Whitcombe MJ, Prachayasittikul V, Mosbach K, Ye L (2006) Biosens Bioelectron 22:349
Teodorescu M, Matyjaszewski K (2000) Macromol Rapid Commun 21:190
Xia J, Zhang X, Matyjaszewski K (1999) Macromolecules 32:3531
Wei X, Li X, Husson SM (2005) Biomacromolecules 6:1113
Li X, Husson SM (2006) Biosens Bioelectron 22:336
Wei X, Husson SM (2007) Ind Eng Chem Res 46:2117
Zu BY, Pan GQ, Guo XZ, Zhang Y, Zhang HQ (2009) J Polym Sci A Polym Chem 47:3257
Sasaki S, Ooya T, Takeuchi T (2010) Polym Chem 1:1684
Zu BY, Zhang Y, Guo XZ, Zhang HQ (2010) J Polym Sci A Polym Chem 48:532
Sulitzky C, Ruckert B, Hall AJ, Lanza F, Unger K, Sellergren B (2002) Macromolecules 35:79
Vaughan AD, Zhang JB, Byrne ME (2010) AIChE J 56:268
Lu C, Zhou W, Han B, Yang H, Chen X, Wang X (2007) Anal Chem 79:5457
Pan GQ, Zu BY, Guo XZ, Zhang Y, Li CX, Zhang HQ (2009) Polymer 50:2819
Pan G, Ma Y, Zhang Y, Guo X, Li C, Zhang H (2011) Soft Matter 7:8428
Pichon V, Haupt K (2006) J Liq Chromatogr Relat Technol 29:989
Andersson LI (1996) Anal Chem 68:111
Bengtsson H, Roos U, Andersson LI (1997) Anal Comm 34:233
Haupt K, Dzgoev A, Mosbach K (1998) Anal Chem 70:628
Caro E, Marcé RM, Cormack PAG, Sherrington DC, Borrull F (2004) J Chromatogr A 1047:175
Haupt K, Mayes AG, Mosbach K (1998) Anal Chem 70:3936
Legido-Quigley C, Oxelbark J, De Lorenzi E, Zurutuza-Elorza A, Cormack PAG (2007) Anal Chim Acta 591:22
Díaz-Alvarez M, Turiel E, Martín-Esteban A (2009) Anal Bioanal Chem 393:899
Sun H-W, Qiao F-X (2008) J Chromatogr A 1212:1
Wulff G, Biffis A (2001) In: Sellergren B (ed) Molecularly imprinted polymers: man-made mimics of antibodies and their applications in analytical chemistry. Elsevier, Amsterdam, pp 71–111
Wulff G, Schönfeld R (1998) Adv Mater 10:957
Sellergren B (1994) Anal Chem 66:1578
Lübke C, Lübke M, Whitcombe MJ, Vulfson EN (2000) Macromolecules 33:5098
Urraca JL, Moreno-Bondi MC, Hall AJ, Sellergren B (2007) Anal Chem 79:695
Sadlej-Sosnowska N (1997) J Incl Phenom Mol Rec Chem 27:31
Piletsky SA, Andersson HS, Nicholls IA (1998) J Mol Recogn 11:94
Song SH, Shirasaka K, Hirokawa Y, Asanuma H, Wada T, Sumaoka J, Komiyama M (2010) Supramol Chem 22:149
Hishiya T, Shibata M, Kakazu M, Asanuma H, Komiyama M (1999) Macromolecules 32:2265
Hochuli E, Döbeli H, Schacher A (1987) J Chromatogr A 411:177
Hart BR, Shea KJ (2002) Macromolecules 35:6192
Hart BR, Shea KJ (2001) J Am Chem Soc 123:2072
Striegler S (2001) Tetrahedron 57:2349
Striegler S (2004) J Chromatogr B 804:183
Tse Sum Bui B, Haupt K (2010) Anal Bioanal Chem 398:2481
Andersson LI, Müller R, Mosbach K (1996) Macromol Res Comm 17:65
Fu GQ, Zhu J, Jiang YZ (2008) Anal Chem 80:2634
Verheyen E, Schillemans JP, van Wijk M, Demeniex MA, Hennink WE, van Nostrum CF (2011) Biomaterials 32:3008
Hjertén S, Liao JL, Nakazato K, Wang Y, Zamaratskaia G, Zhang HX (1997) Chromatographia 44:227
Janiak DS, Kofinas P (2007) Anal Bioanal Chem 389:399
Hansen DE (2007) Biomaterials 28:4178
Bossi A, Bonini F, Turner APF, Piletsky SA (2007) Biosens Bioelectron 22:1131
Shi HQ, Tsai WB, Garrison MD, Ferrari S, Ratner BD (1999) Nature 398:593
El Kirat K, Bartkowski M, Haupt K (2009) Biosens Bioelectron 24:2618
Linares AV, Vandevelde F, Pantigny J, Falcimaigne-Cordin A, Haupt K (2009) Adv Funct Mater 19:1
Uysal A, Demirel G, Turan E, Çaykara T (2008) Anal Chim Acta 625:110
Casey BJ, Kofinas P (2008) J Biomed Mater Res A 87A:359
Cutivet A, Schembri C, Kovensky J, Haupt K (2009) J Am Chem Soc 131:14699
Hoshino Y, Kodama T, Okahata Y, Shea KJ (2008) J Am Chem Soc 130:15242
Hoshino Y, Urakami T, Kodama T, Koide H, Oku N, Okahata Y, Shea KJ (2009) Small 5:1562
Hoshino Y, Koide H, Urakami T, Kanazawa H, Kodama T, Oku N, Shea KJ (2010) J Am Chem Soc 132:6644
Rachkov A, Minoura N (2000) J Chromatogr A 889:111
Rachkov A, Minoura N (2001) Biochim Biophys Acta 1544:255
Nishino H, Huang C-S, Shea KJ (2006) Angew Chem Int Ed 45:2392
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Haupt, K., Linares, A.V., Bompart, M., Bui, B.T.S. (2011). Molecularly Imprinted Polymers. In: Haupt, K. (eds) Molecular Imprinting. Topics in Current Chemistry, vol 325. Springer, Berlin, Heidelberg. https://doi.org/10.1007/128_2011_307
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DOI: https://doi.org/10.1007/128_2011_307
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