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Application of Activity-Based Protein Profiling to the Study of Microbial Pathogenesis

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Activity-Based Protein Profiling

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 324))

Abstract

Activity-based protein profiling (ABPP) is a powerful technology for the dissection of dynamic and complex enzyme interactions. The mechanisms involved in microbial pathogenesis are an example of just such a system, with a plethora of highly regulated enzymatic interactions between the infecting organism and its host. In this review we will discuss some of the cutting-edge applications of ABPP to the study of bacterial and parasitic pathogenesis and virulence, with an emphasis on Clostridium difficile, methicillin-resistant Staphylococcus aureus, quorum sensing, and malaria.

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Authors and Affiliations

  1. Department of Chemistry, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK

    William P. Heal & Edward W. Tate

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  1. William P. Heal
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  2. Edward W. Tate
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Correspondence to Edward W. Tate .

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Editors and Affiliations

  1. Technical University of Munich, Department of Organic Chemistry II, Lichtenbergstr. 4, Garching, 85747, Germany

    Stephan A. Sieber

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Heal, W.P., Tate, E.W. (2011). Application of Activity-Based Protein Profiling to the Study of Microbial Pathogenesis. In: Sieber, S. (eds) Activity-Based Protein Profiling. Topics in Current Chemistry, vol 324. Springer, Berlin, Heidelberg. https://doi.org/10.1007/128_2011_299

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