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Total (Bio)Synthesis: Strategies of Nature and of Chemists

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Natural Products via Enzymatic Reactions

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 297))

Abstract

The biosynthetic pathways to a number of natural products have been reconstituted in vitro using purified enzymes. Many of these molecules have also been synthesized by organic chemists. Here we compare the strategies used by nature and by chemists to reveal the underlying logic and success of each total synthetic approach for some exemplary molecules with diverse biosynthetic origins.

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Acknowledgments

This work was supported by National Institutes of Health grants GM85770 and AI47818 to B.S.M., a postdoctoral fellowship from the German Academic Exchange Service (DAAD) to T.A.M.G. and a Howard Hughes Medical Institute sponsored Life Sciences Research Foundation postdoctoral fellowship to K.S.R.

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  1. Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA, 92093, USA

    Alexandra A. Roberts, Katherine S. Ryan, Bradley S. Moore & Tobias A. M. Gulder

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  1. Alexandra A. Roberts
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  2. Katherine S. Ryan
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  3. Bradley S. Moore
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  4. Tobias A. M. Gulder
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Correspondence to Bradley S. Moore or Tobias A. M. Gulder .

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  1. Kekulé-Institut für Organische, Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, Bonn, 53121, Germany

    Jörn Piel

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Roberts, A.A., Ryan, K.S., Moore, B.S., Gulder, T.A.M. (2010). Total (Bio)Synthesis: Strategies of Nature and of Chemists. In: Piel, J. (eds) Natural Products via Enzymatic Reactions. Topics in Current Chemistry, vol 297. Springer, Berlin, Heidelberg. https://doi.org/10.1007/128_2010_79

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