Abstract
Based on the logical description of gene regulatory networks developed by R. Thomas, we introduce an enhanced modelling approach that uses timed automata. It yields a refined qualitative description of the dynamics of the system incorporating information not only on ratios of kinetic constants related to synthesis and decay, but also on the time delays occurring in the operations of the system. We demonstrate the potential of our approach by analysing an illustrative gene regulatory network of bacteriophage λ.
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Siebert, H., Bockmayr, A. (2006). Incorporating Time Delays into the Logical Analysis of Gene Regulatory Networks. In: Priami, C. (eds) Computational Methods in Systems Biology. CMSB 2006. Lecture Notes in Computer Science(), vol 4210. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11885191_12
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DOI: https://doi.org/10.1007/11885191_12
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-46166-1
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