Abstract
We present a two-step process including white matter atlas generation and automatic segmentation. Our atlas generation method is based on population fiber clustering. We produce an atlas which contains high-dimensional descriptors of fiber bundles as well as anatomical label information. We use the atlas to automatically segment tractography in the white matter of novel subjects and we present quantitative results (FA measurements) in segmented white matter regions from a small population. We demonstrate reproducibility of these measurements across scans. In addition, we introduce the idea of using clustering for automatic matching of anatomical structures across hemispheres.
Chapter PDF
Similar content being viewed by others
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
Basser, P., Pajevic, S., Pierpaoli, C., Duda, J., Aldroubi, A.: In vivo fiber tractography using DT–MRI data. Magnetic Resonance in Medicine 44, 625–632 (2000)
Concha, L., Beaulieu, C., Gross, D.W.: Bilateral limbic diffusion abnormalities in unilateral temporal lobe epilepsy. Annals of Neurology 57(2), 188–196 (2004)
Jones, D.K., Catani, M., Pierpaoli, C., Reeves, S.J., Shergill, S.S., O’Sullivan, M., Golesworthy, P., McGuire, P., Horsfield, M.A., Simmons, A., Williams, S.C., Howard, R.J.: Age effects on diffusion tensor magnetic resonance imaging tractography measures of frontal cortex connections in schizophrenia. Human Brain Mapping (2005)
Partridge, S.C., Mukherjee, P., Berman, J.I., Henry, R.G., Miller, S.P., Lu, Y., Glenn, O.A., Ferriero, D.M., Barkovich, A.J., Vigneron, D.B.: Tractography-based quantitation of diffusion tensor imaging parameters in white matter tracts of preterm newborns. Magnetic Resonance in Medicine 22(4), 467–474 (2005)
Catani, M., Howard, R.J., Pajevic, S., Jones, D.K.: Virtual in vivo interactive dissection of white matter fasciculi in the human brain. NeuroImage 17, 77–79 (2002)
Mori, S., Wakana, S., Nagae-Poetscher, L.M., van Zijl, P.C.: MRI Atlas of Human White Matter. Elsevier, Amsterdam (2005)
Brun, A., Knutsson, H., Park, H.J., Shenton, M.E., Westin, C.F.: Clustering Fiber Traces Using Normalized Cuts. In: Barillot, C., Haynor, D.R., Hellier, P. (eds.) MICCAI 2004. LNCS, vol. 3216, pp. 368–375. Springer, Heidelberg (2004)
Gerig, G., Gouttard, S., Corouge, I.: Analysis of brain white matter via fiber tract modeling. In: EMBS, p. 426 (2004)
O’Donnell, L., Westin, C.F.: White Matter Tract Clustering and Correspondence in Populations. In: Duncan, J.S., Gerig, G. (eds.) MICCAI 2005. LNCS, vol. 3749, pp. 140–147. Springer, Heidelberg (2005)
Corouge, I., Gouttard, S., Gerig, G.: Towards a shape model of white matter fiber bundles using diffusion tensor MRI. In: ISBI, pp. 344–347 (2004)
Maddah, M., Mewes, A., Haker, S., Grimson, W.E.L., Warfield, S.: Automated Atlas-Based Clustering of White Matter Fiber Tracts from DTMRI. In: Duncan, J.S., Gerig, G. (eds.) MICCAI 2005. LNCS, vol. 3749, pp. 188–195. Springer, Heidelberg (2005)
Behrens, T., Johansen-Berg, H., Woolrich, M., Smith, S., Wheeler-Kingshott, C., Boulby, P., Barker, G., Sillery, E., Sheehan, K., Ciccarelli, O., Thompson, A., Brady, J., Matthews, P.: Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging. Nature Neuroscience 6, 750–757 (2003)
Parker, G.J., Wheeler-Kingshott, C.A., Barker, G.J.: Estimating distributed anatomical connectivity using fast marching methods and diffusion tensor imaging. IEEE TMI 21(5), 505–512 (2002)
Westin, C.F., Maier, S., Mamata, H., Nabavi, A., Jolesz, F., Kikinis, R.: Processing and visualization of diffusion tensor MRI. Medical Image Analysis 6(2), 93–108 (2002)
Basser, P., Pierpaoli, C.: Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. J. Magn. Reson. Ser. B 111, 209–219 (1996)
Zollei, L., Learned-Miller, E., Grimson, W.E.L., Wells, I.W.M.: Efficient population registration of 3D data. In: ICCV 2005, Computer Vision for Biomedical Image Applications (2005)
Brun, A., Park, H.J., Knutsson, H., Westin, C.F.: Coloring of DT-MRI Fiber Traces Using Laplacian Eigenmaps. In: Moreno-Díaz Jr., R., Pichler, F. (eds.) EUROCAST 2003. LNCS, vol. 2809, pp. 564–572. Springer, Heidelberg (2003)
Wang, X., Tieu, K., Grimson, E.: Learning semantic scene models by trajectory analysis. Technical report, MIT CSAIL (2006)
Shi, J., Malik, J.: Normalized cuts and image segmentation. PAMI 22(8), 888–905 (2000)
Fowlkes, C., Belongie, S., Chung, F., Malik, J.: Spectral grouping using the Nystrom method. PAMI 26(2), 214–225 (2004)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
O’Donnell, L., Westin, CF. (2006). High-Dimensional White Matter Atlas Generation and Group Analysis. In: Larsen, R., Nielsen, M., Sporring, J. (eds) Medical Image Computing and Computer-Assisted Intervention – MICCAI 2006. MICCAI 2006. Lecture Notes in Computer Science, vol 4191. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11866763_30
Download citation
DOI: https://doi.org/10.1007/11866763_30
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-44727-6
Online ISBN: 978-3-540-44728-3
eBook Packages: Computer ScienceComputer Science (R0)