Abstract
In minimally invasive tumor resection, the desirable goal is to perform a minimal but complete removal of cancerous cells. In the last decades interventional nuclear medicine probes supported the detection of remaining tumor cells. However, scanning the patient with an intraoperative probe and applying the treatment are not done simultaneously. The main contribution of this work is to extend the one dimensional signal of a beta-probe to a four dimensional signal including the spatial information of the distal end of the probe. We generate a color encoded surface map of the scanned activity and guide any tracked surgical instrument back to the regions with measured activity. For navigation, we implement an augmented reality visualization that superimposes the acquired surface on a visual image of the real anatomy. Alternatively, a simulated beta-probe count rate in the tip of a tracked therapeutic instrument is simulated showing the count number and coding it as an acoustic signal. Preliminary tests were performed showing the feasibility of the new designed system and the viability of such a three dimensional intraoperative molecular imaging modality.
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References
Phelps, M.E.: PET: The merging of biology and imaging into molecular imaging. The Journal of Nuclear Medicine 41(4), 661–681 (2000)
Levin, C.S., Restom, T.S., Kapelanski, D.P., Hoh, C.K.: A simple surgical probe that directly detects positrons emitted from radiolabeled malignant tissue. Proceedings of the SNM 50th Annual Meeting 44(5) (2003)
Daghighian, F., Mazziotta, J.C., Hoffman, E.J., Shenderov, P., Eshaghian, B., Siegel, S., Phelps, M.E.: Intraoperative beta probe: A device for detecting tissue labeled with positron or electron emitting isotopes during surgery. Med. Phys. 21(1), 153–157 (1994)
Raylman, R.R., Wahl, R.L.: Evaluation of ion-implanted-silicon detectors for use in intraoperative positron-sensitive probes. Med. Phys. 23(11), 1889–1895 (1996)
Weisenberg, A.G.: Gamma-ray blind beta probe. US Patent 6,317,622 (2001)
Sielhorst, T., Feuerstein, M., Traub, J., Kutter, O., Navab, N.: Campar: A software framework guaranteeing quality for medical augmented reality. In: Proceedings of CARS 2006 (to appear, 2006)
Hoff, W.A., Vincent, T.L.: Analysis of head pose accuracy in augmented reality. IEEE Trans. Visualization and Computer Graphics 6 (2000)
Hartley, R., Zisserman, A.: Multiple View Geometry in Computer Vision, 2nd edn. Cambridge University Press, Cambridge (2003)
Daniilidis, K.: Hand - eye calibration using dual quaternions. Journal of Robotics Research 18, 286–298 (1999)
Scibilia, G., Soluri, A.: Surgical probe for laparoscopy or intracavitary tumor localization. US patent 6,021,341 (2000)
Daghighian, F., Walker, R.E., Leon, B.J.: Methods and devices to expand applications of intraoperative radiation probes. US patent 6,510,336 B1 (2003)
Raylman, R.R., Hyder, A.: A dual surface barrier detector unit for beta-sensitive endoscopic probes. IEEE Trans. Nucl. Sci. 51(1), 117–122 (2004)
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© 2006 Springer-Verlag Berlin Heidelberg
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Wendler, T., Traub, J., Ziegler, S.I., Navab, N. (2006). Navigated Three Dimensional Beta Probe for Optimal Cancer Resection. In: Larsen, R., Nielsen, M., Sporring, J. (eds) Medical Image Computing and Computer-Assisted Intervention – MICCAI 2006. MICCAI 2006. Lecture Notes in Computer Science, vol 4190. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11866565_69
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DOI: https://doi.org/10.1007/11866565_69
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-44707-8
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