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The Cardiomyocyte Cell Cycle in Hypertrophy, Tissue Homeostasis, and Regeneration

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Reviews of Physiology, Biochemistry and Pharmacology, Vol. 165

Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology ((REVIEWS,volume 165))

Abstract

Mammalian cardiomyocytes withdraw from the cell cycle shortly after birth. Although the adult heart is unable to regenerate, numerous reports have shown that adult cardiomyocytes exhibit a dynamic range of cell cycle activity under various physiological and pathological conditions. Reason and consequence of cardiomyocyte cell cycle activity remain unclear and have led to a number of misconceptions. Understanding the scenarios in which cycling happens may promote new perspectives on the differentiated state of cardiomyocytes, treatments for hypertrophy, heart regeneration and cancer therapy. In this review we discuss the result of cardiomyocyte cell cycle activity in aging and disease and studies manipulating cardiac cell cycle activity to promote cardiac regeneration. In addition, we focus on cardiomyocyte differentiation, cell cycle exit, and the relationship between ploidy and regenerative potential. Finally, we provide observations that may further advance the goal of inducing adult mammalian heart regeneration through cardiomyocyte proliferation.

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Acknowledgments

This work was supported by the Alexander von Humboldt Foundation (Sofja Kovalevskaja Award to F.B.E.) and the DFG (EN 453/9-1).

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Authors and Affiliations

  1. Department of Cardiac Development and Remodelling, Max-Planck-Institute for Heart and Lung Research, Parkstrasse 1, Bad Nauheim, 61231, Germany

    David C. Zebrowski & Felix B. Engel

  2. Department of Nephropathology, Institute of Pathology, Laboratory of Experimental Renal and Cardiovascular Research, University of Erlangen-Nürnberg, Universitätsstraße 22, Erlangen, 91054, Germany

    Felix B. Engel

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  1. David C. Zebrowski
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  2. Felix B. Engel
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Correspondence to Felix B. Engel .

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Editors and Affiliations

  1. Dept. of Cell. and Molecular Medicine Lab. of Ion Channel Research, KU Leuven, Leuven, Belgium

    Bernd Nilius

  2. Deptartment of Neurobiology Biomedical Science Tower 3, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Susan G. Amara

  3. Walther-Straub-Institut für Pharmakologi, Ludwig-Maximilians-Universität München Medizinische Fakultät, München, Germany

    Thomas Gudermann

  4. MPI für Biophysikalische Chemie Abt. Neurobiologie, Göttingen, Germany

    Reinhard Jahn

  5. Zytopathologie, Universität Marburg Inst. Zytobiologie und, Marburg, Germany

    Roland Lill

  6. Abteilung II, Max-Planck-Institut für Herz- und Lungen, Bad Nauheim, Germany

    Stefan Offermanns

  7. Cardiff University School of Biosciences, Cardiff, United Kingdom

    Ole H. Petersen

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Zebrowski, D.C., Engel, F.B. (2013). The Cardiomyocyte Cell Cycle in Hypertrophy, Tissue Homeostasis, and Regeneration. In: Nilius, B., et al. Reviews of Physiology, Biochemistry and Pharmacology, Vol. 165. Reviews of Physiology, Biochemistry and Pharmacology, vol 165. Springer, Cham. https://doi.org/10.1007/112_2013_12

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