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Induced Pluripotent Stem Cells: Characteristics and Perspectives

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Bioreactor Systems for Tissue Engineering II

Part of the book series: Advances in Biochemical Engineering / Biotechnology ((ABE,volume 123))

Abstract

The induction of pluripotency in somatic cells is widely considered as a major breakthrough in regenerative medicine, because this approach provides the basis for individualized stem cell-based therapies. Moreover, with respect to cell transplantation and tissue engineering, expertise from bioengineering to transplantation medicine is now meeting basic research of stem cell biology.

In this chapter, we discuss techniques, potential and possible risks of induced pluripotent stem (iPS) cells in the light of needs for patient-derived pluripotent stem cells. To this end, we compare these cells with other sources of pluripotent cells and discuss the first encouraging results of iPS cells in pharmacological research, disease modeling and cell transplantation, providing fascinating perspectives for future developments in biotechnology and regenerative medicine.

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Acknowledgments

We are very grateful to the members of our labs for providing intensive discussions and a lot of critical input, which contributed to this review. Both authors are group leaders within the cluster of excellence REBIRTH (REgenerative BIology and Reconstructive THerapy), which is funded by the German Research Foundation (DFG; EXC 62/1). Further funding is provided by the DFG (MA 2331/6-1, SCHO 340/4-1), the Federal Ministry of Education and Research through grants 0313926A, 01GN0812, 01GN0816 and 01GM0854, 01GN0958 and 0315493, as well as by the José Carreras leukemia foundation (DJCLS R09/01).

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Authors and Affiliations

  1. Junior Research Group Stem Cell Biology, Excellence Cluster REBIRTH, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany

    Tobias Cantz

  2. Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Excellence Cluster REBIRTH, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany

    Ulrich Martin

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  1. Tobias Cantz
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  2. Ulrich Martin
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Correspondence to Ulrich Martin .

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Editors and Affiliations

  1. Inst. Technische Chemie, Universität Hannover, Callinstr. 3, Hannover, 30167, Germany

    Cornelia Kasper

  2. Klinische und Experimentelle, Traumatologie, Ludwig Boltzmann Institut für, Donaueschingenstr. 13, Wien, 1200, Austria

    Martijn van Griensven

  3. Inst.Biotechnologie u. Verfahrenstechnik, TU Hamburg-Harburg, Denickestr. 15, Hamburg, 21073, Germany

    Ralf Pörtner

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Cantz, T., Martin, U. (2010). Induced Pluripotent Stem Cells: Characteristics and Perspectives. In: Kasper, C., van Griensven, M., Pörtner, R. (eds) Bioreactor Systems for Tissue Engineering II. Advances in Biochemical Engineering / Biotechnology, vol 123. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2010_74

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