Skip to main content
SpringerLink
Log in

Expression and Function of Somatostatin and its Receptors in Immune Cells

  • Chapter
Somatostatin

Part of the book series: Endocrine Updates ((ENDO,volume 24))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 54.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Elliott, D.E. Schistosomiasis: pathophysiology, diagnosis, and treatment. Gastroenterology Clinics of North America 1996 25(3):599–625.

    Article  CAS  PubMed  Google Scholar 

  2. Elliott DE. Methods used to study immunoregulation of schistosome egg granulomas. Methods: A Companion to Methods in Enzymology 1996;9:255–67.

    Article  CAS  PubMed  Google Scholar 

  3. Rakasz E, Blum AM, Metwali A, Elliott DE, Li J, Ballas ZK, Qadir K, Lynch R, Weinstock JV. Localization and regulation of IFN-gamma production within the granulomas of murine schistosomiasis in IL-4-deficient and control mice. J.Immunol. 1998;160(10):4994–9.

    CAS  PubMed  Google Scholar 

  4. Weinstock JV, Blum AM, Malloy T. Macrophages within the granulomas of murine Schistosoma mansoni are a source of a somatostatin 1–14-like molecule. Cellular Immunology 1990;131(2):381–90.

    Article  CAS  PubMed  Google Scholar 

  5. Elliott DE, Blum AM, Li J, Metwali A, Weinstock JV. Preprosomatostatin messenger RNA is expressed by inflammatory cells and induced by inflammatory mediators and cytokines. J.Immunol. 1998;160(8):3997–4003.

    CAS  PubMed  Google Scholar 

  6. Blum AM, Metwali A, Mathew RC, Cook G, Elliott D, Weinstock JV. Granuloma T Lymphocytes in murine schistosomiasis mansoni have somatostatin receptors and respond to somatostatin with decreased IFN-gamma secretion. J. Immunol. 1992;149(11):3621–6.

    CAS  PubMed  Google Scholar 

  7. Blum AM, Elliott DE, Metwali A, Li J, Qadir K, Weinstock JV. Substance P regulates somatostatin expression in inflammation. J.Immunol. 1998;161(11):6316–22.

    CAS  PubMed  Google Scholar 

  8. Elliott DE, Li J, Blum AM, Metwali A, Patel YC, Weinstock JV. SSTR2A is the dominant somatostatin receptor subtype expressed by inflammatory cells, is widely expressed and directly regulates T cell IFN-gamma release. Eur. J. Immunol. 1999;29(8):2454–63.

    Article  CAS  PubMed  Google Scholar 

  9. Farrar MA, Schreiber RD. The molecular cell biology of interferon-gamma and its receptor. Annual Review of Immunology 1993;11:571–611.

    Article  CAS  PubMed  Google Scholar 

  10. Romagnani S. Lymphokine production by human T cells in disease states. Annual Review of Immunology 1994; 12:227–57.

    Article  CAS  PubMed  Google Scholar 

  11. Swain SL, Bradley LM, Croft M, Tonkonogy S, Atkins G, Weinberg AD, Duncan DD, Hedrick SM, Dutton RW, Huston G. Helper T-cell subsets: phenotype, function and the role of lymphokines in regulating their development. Immunological Reviews 1991;123:115–44.

    CAS  PubMed  Google Scholar 

  12. Blum AM, Metwali A, Mathew RC, Elliott D, Weinstock JV. Substance P and somatostatin can modulate the amount of IgG2a secreted in response to schistosome egg antigens in murine schistosomiasis mansoni. J. Immunol. 1993;151(12):6994–7004.

    CAS  PubMed  Google Scholar 

  13. Bruno JF, Xu Y, Song J, Berelowitz M. Molecular cloning and functional expression of a brain-specific somatostatin receptor. Proc. Natl. Acad. Sci. USA 1992;89(23):11151–5.

    CAS  PubMed  Google Scholar 

  14. Corness JD, Demchyshyn LL, Seeman P, Van Tol HH, Srikant CB, Kent G, Patel YC, Niznik HB. A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides. FEBS Lett. 1993;321(2–3):279–84.

    CAS  PubMed  Google Scholar 

  15. Demchyshyn LL, Srikant CB, Sunahara RK, Kent G, Seeman P, Van Toi HH, Panetta R, Patel YC, Niznik HB. Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20. Mol Pharmacol 1993;43(6):894–901.

    CAS  PubMed  Google Scholar 

  16. O’Carroll AM, Lolait SJ, Konig M, Mahan LC. Molecular cloning and expression of a pituitary somatostatin receptor with preferential affinity for somatostatin-28. Mol Pharmacol 1992;42(6):939–46.

    CAS  PubMed  Google Scholar 

  17. Panetta R, Greenwood MT, Warszynska A, Demchyshyn LL, Day R, Niznik, HB, Srikant CB, Patel YC. Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28. Mol Pharmacol 1994;45(3):417–27.

    CAS  PubMed  Google Scholar 

  18. Rohrer L, Raulf F, Bruns C, Buettner R, Hofstaedter F, Schule R. Cloning and characterization of a fourth human somatostatin receptor. Proc. Natl. Acad. Sci. USA 1993;90(9):4196–200.

    CAS  PubMed  Google Scholar 

  19. Yamada Y, Reisine T, Law SF, Ihara Y, Kubota A, Kagimoto S, Seino M, Seino Y, Bell GI, Seino S. Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase. Mol. Endocrinol. 1992;6(12):2136–42.

    Article  CAS  PubMed  Google Scholar 

  20. Yamada Y, Post SR, Wang K, Tager HS, Bell GI, Seino S. Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. Proc. Natl. Acad. Sci. USA 1992;89(1):251–5.

    CAS  PubMed  Google Scholar 

  21. Yasuda K, Rens-Domiano S, Breder CD, Law SF, Saper CB, Reisine T, Bell GI. Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase. J. Biol. Chem. 1992;267(28):20422–8.

    CAS  PubMed  Google Scholar 

  22. Elliott DE, Metwali A, Blum AM, Sandor M, Lynch R, Weinstock JV. T lymphocytes isolated from the hepatic granulomas of schistosome-infected mice express somatostatin receptor subtype II (SSTR2) messenger RNA. J. Immunol. 1994;153(3):1180–6.

    CAS  PubMed  Google Scholar 

  23. Patel YC, Panetta R, Escher E, Greenwood M, Srikant CB. Expression of multiple somatostatin receptor genes in AtT-20 cells. Evidence for a novel somatostatin-28 selective receptor subtype. J. Biol. Chem. 1994;269(2):1506–9.

    CAS  PubMed  Google Scholar 

  24. Patel YC, Greenwood M, Kent G, Panetta R, Srikant CB. Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation. Biochem. Biophys. Res. Commun. 1993;192(1):288–94.

    Article  CAS  PubMed  Google Scholar 

  25. Reisine T, Kong H, Raynor K, Yano H, Takeda J, Yasuda K, Bell GI. Splice variant of the somatostatin receptor 2 subtype, somatostatin receptor 2B, couples to adenylyl cyclase. Mol Pharmacol 1993;44(5): 1016–20.

    CAS  PubMed  Google Scholar 

  26. Vanetti M, Kouba M, Wang X, Vogt G, Hollt V. Cloning and expression of a novel mouse somatostatin receptor (SSTR2B). FEBS Lett. 1992;311(3):290–4.

    Article  CAS  PubMed  Google Scholar 

  27. Alderton F, Fan TP, Schindler M, Humphrey PP. Rat somatostatin sst2(a) and sst2(b) receptor isoforms mediate opposite effects on cell proliferation. British Journal of Pharmacology 1998; 125(8): 1630–3.

    Article  CAS  PubMed  Google Scholar 

  28. Kraus J, Woltje M, Schonwetter N, Hollt V. Alternative promoter usage and tissue specific expression of the mouse somatostatin receptor 2 gene. FEBS Lett. 1998;428(3): 165–70.

    Article  CAS  PubMed  Google Scholar 

  29. Weinstock JV, Elliott D. The substance P and somatostatin interferon-g immunoregulatory circuit. Annals of the New York Academy of Sciences 1998;840:532–9.

    Article  CAS  PubMed  Google Scholar 

  30. Boom WH, Liano D, Abbas AK. Heterogeneity of helper/inducer T lymphocytes. II. Effects of interleukin 4-and interleukin 2-producing T cell clones on resting B lymphocytes. Journal of Experimental Medicine 1988;167(4):1350–63.

    Article  CAS  PubMed  Google Scholar 

  31. Blum AM, Metwali A, Cook G, Mathew RC, Elliott D, Weinstock JV. Substance P modulates antigen-induced, IFN-gamma production in murine Schistosomiasis mansoni. J. Immunol. 1993;151(l):225–33.

    CAS  PubMed  Google Scholar 

  32. Blum AM, Metwali A, Kim-Miller M, Li J, Qadir K, Elliott DE, Lu B, Fabry Z, Gerard N, Weinstock JV. The substance P receptor is necessary for a normal granulomatous response in murine schistosomiasis mansoni. J. Immunol. 1999;162(10):6080–5.

    CAS  PubMed  Google Scholar 

  33. Stanisz AM, Befus D, Bienenstock J. Differential effects of vasoactive intestinal peptide, substance P, and somatostatin on immunoglobulin synthesis and proliferations by lymphocytes from Peyer’s patches, mesenteric lymph nodes, and spleen. J. Immunol. 1986;136(1):152–6.

    CAS  PubMed  Google Scholar 

  34. Krco CJ, Gores A, Go VL. Gastrointestinal regulatory peptides modulate in vitro immune reactions of mouse lymphoid cells. Clinical Immunology & Immunopathology 1986;39(2):308–18.

    CAS  Google Scholar 

  35. Agro A, Padol I, Stanisz AM. Immunomodulatory activities of the somatostatin analogue BIM 23014c: effects on murine lymphocyte proliferation and natural killer activity. Regulatory Peptides 1991;32(2): 129–39.

    Article  CAS  PubMed  Google Scholar 

  36. Levite M. Neuropeptides, by direct interaction with T cells, induce cytokine secretion and break the commitment to a distinct T helper phenotype. Proc. Natl. Acad. Sci. USA 1998;95(21): 12544–9.

    Article  CAS  PubMed  Google Scholar 

  37. Stanisz AM, Scicchitano R, Payan DG, Bienenstock J. In vitro studies of immunoregulation by substance P and somatostatin. Annals of the New York Academy of Sciences 1987;496:217–25.

    CAS  PubMed  Google Scholar 

  38. Scicchitano R, Dazin P, Bienenstock J, Payan DG, Stanisz AM. The murine IgA-secreting plasmacytoma MOPC-315 expresses somatostatin receptors. J. Immunol. 1988;141(3):937–41.

    CAS  PubMed  Google Scholar 

  39. Kronheim S, Berelowitz M, Pimstone BL. A radioimmunoassay for growth hormone release-inhibiting hormone: method and quantitative tissue distribution. Clinical Endocrinology 1976;5(6):619–30.

    CAS  PubMed  Google Scholar 

  40. Fuller PJ, Verity K. Somatostatin gene expression in the thymus gland. J. Immunol. 1989;143(3):1015–7.

    CAS  PubMed  Google Scholar 

  41. Aguila MC, Dees WL, Haensly WE, McCann SM. Evidence that somatostatin is localized and synthesized in lymphoid organs. Proc. Natl. Acad. Sci. USA 1991;88(24):11485–9.

    CAS  PubMed  Google Scholar 

  42. Mascardo RN, Barton RW, Sherline P. Somatostatin has an antiproliferative effect on concanavalin A-activated rat thymocytes. Clinical Immunology & Immunopathology 1984;33(1):131–8.

    CAS  Google Scholar 

  43. Aguila MC, Rodriguez AM, Aguila-Mansilla HN, Lee WT. Somatostatin antisense oligodeoxynucleotide-mediated stimulation of lymphocyte proliferation in culture. Endocrinology 1996;137(5):1585–90.

    Article  CAS  PubMed  Google Scholar 

  44. Krieg AM, Yi AK, Matson S, Waldschmidt TJ, Bishop GA, Teasdale R, Koretzky GA, Klinman DM. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 1995;374(6522):546–9.

    Article  CAS  PubMed  Google Scholar 

  45. Sedqi M, Roy S, Mohanraj D, Ramakrishnan S, Loh HH. Activation of rat thymocytes selectively upregulates the expression of somatostatin receptor subtype-1. Biochem. Mol. Biol. Int. 1996;38(1):103–12.

    CAS  PubMed  Google Scholar 

  46. ten Bokum AM, Lichtenauer-Kaligis EG, Melief MJ, van Koetsveld PM, Bruns C, van Hagen PM, Hofland LJ, Lamberts SW, Hazenberg MP. Somatostatin receptor subtype expression in cells of the rat immune system during adjuvant arthritis. Journal of Endocrinology 1999;161(1):167–75.

    PubMed  Google Scholar 

  47. Rees RG, Eckland DJA, Lightman SL, Brewerton DA. The effects of somatostatin analogue, BM23014, on adjuvant arthritis in rats. British Journal of Rheumatology 1989;28(Supplement 2):40

    Google Scholar 

  48. Karalis K, Mastorakos G, Chrousos GP, Tolis G. Somatostatin analogues suppress the inflammatory reaction in vivo. Journal of Clinical Investigation 1994;93(5):2000–6.

    CAS  PubMed  Google Scholar 

  49. Ferone D, van Hagen PM, van Koetsveld PM, Zuijderwijk J, Mooy DM, Lichtenauer-Kaligis EG, Colao A, Bogers AJ, Lombardi G, Lamberts SW, et al. In vitro characterization of somatostatin receptors in the human thymus and effects of somatostatin and octreotide on cultured thymic epithelial cells. Endocrinology 1999;140(1):373–80.

    Article  CAS  PubMed  Google Scholar 

  50. Talme T, Schultzberg M, Sundqvist KG, Marcusson JA. Colocalization of somatostatin-and HLA-DR-like immunoreactivity in dendritic cells of psoriatic skin [see comments]. Acta Dermato-Venereologica 1997;77(5):338–42.

    CAS  PubMed  Google Scholar 

  51. Payan DG, Hess CA, Goetzl EJ. Inhibition by somatostatin of the proliferation of T-lymphocytes and Molt-4 lymphoblasts. Cellular Immunology 1984;84(2):433–8.

    Article  CAS  PubMed  Google Scholar 

  52. Fais S, Annibale B, Boirivant M, Santoro A, Pallone F, Delle FG. Effects of somatostatin on human intestinal lamina propria lymphocytes. Modulation of lymphocyte activation. Journal of Neuroimmunology 1991;31(3):211–9.

    Article  CAS  PubMed  Google Scholar 

  53. Tang SC, Braunsteiner H, Wiedermann CJ. Regulation of human T lymphoblast growth by sensory neuropeptides: augmentation of cholecystokinin-induced inhibition of Molt-4 proliferation by somatostatin and vasoactive intestinal peptide in vitro. Immunology Letters 1992;34(3):237–42.

    Article  CAS  PubMed  Google Scholar 

  54. Yousefi S, Ghazinouri A, Vaziri N, Tilles J, Carandang G, Cesario T. The effect of somatostatin on the production of human interferons by mononuclear cells. Proceedings of the Society for Experimental Biology & Medicine 1990;194(2):114–8.

    CAS  Google Scholar 

  55. Yousefi S, Vaziri N, Carandang G, Le W, Yamamoto R, Granger G, Ocariz J, Cesario T. The paradoxical effects of somatostatin on the bioactivity and production of cytotoxins derived from human peripheral blood mononuclear cells. British Journal of Cancer 1991;64(2):243–6.

    CAS  PubMed  Google Scholar 

  56. Levite M, Cahalon L, Hershkoviz R, Steinman L, Lider O. Neuropeptides, via specific receptors, regulate T cell adhesion to fibronectin. J. Immunol. 1998;160(2):993–1000.

    CAS  PubMed  Google Scholar 

  57. Bhathena SJ, Louie J, Schechter GP, Redman RS, Wahl L, Recant L. Identification of human mononuclear leukocytes bearing receptors for somatostatin and glucagon. Diabetes 1981;30(2):127–31.

    CAS  PubMed  Google Scholar 

  58. Reubi JC, Horisberger U, Waser B, Gebbers JO, Laissue J. Preferential location of somatostatin receptors in germinal centers of human gut lymphoid tissue. Gastroenterology 1992;103(4):1207–14.

    CAS  PubMed  Google Scholar 

  59. Nakamura H, Koike T, Hiruma K, Sato T, Tomioka H, Yoshida S. Identification of lymphoid cell lines bearing receptors for somatostatin. Immunology 1987;62(4):655–8.

    CAS  PubMed  Google Scholar 

  60. Sreedharan SP, Kodama KT, Peterson KE, Goetzl EJ. Distinct subsets of somatostatin receptors on cultured human lymphocytes. J. Biol. Chem. 1989;264(2):949–52.

    CAS  PubMed  Google Scholar 

  61. Tsutsumi A, Takano H, Ichikawa K, Kobayashi S, Koike T. Expression of somatostatin receptor subtype 2 mRNA in human lymphoid cells. Cellular Immunology 1997;181(1):44–9.

    Article  CAS  PubMed  Google Scholar 

  62. Ferone D, van Hagen PM, Colao A, Annunziato L, Lamberts SW, Hofland, LJ. Somatostatin receptors in the thymus. Annals of Medicine 1999;31Suppl 2:28–33.

    CAS  PubMed  Google Scholar 

  63. Reubi JC, Laissue JA, Waser B, Steffen DL, Hipkin RW, Schonbrunn A. Immunohistochemical detection of somatostatin sst2a receptors in the lymphatic, smooth muscular, and peripheral nervous systems of the human gastrointestinal tract: facts and artifacts. Journal of Clinical Endocrinology & Metabolism 1999;84(8):2942–50.

    Article  CAS  Google Scholar 

  64. ten Bokum AM, Melief MJ, Schonbrunn A, van der Ham F, Lindeman J, Hofland LJ, Lamberts SW, van Hagen PM. Immunohistochemical localization of somatostatin receptor sst2A in human rheumatoid synovium. Journal of Rheumatology 1999;26(3):532–5.

    PubMed  Google Scholar 

  65. ten Bokum AM, Hofland LJ, de Jong G, Bouma J, Melief MJ, Kwekkeboom, DJ, Schonbrunn A, Mooy CM, Laman JD, et al. Immunohistochemical localization of somatostatin receptor sst2A in sarcoid granulomas. European Journal of Clinical Investigation 1999;29(7):630–6.

    PubMed  Google Scholar 

  66. Cardoso A, el Ghamrawy C, Gautron JP, Horvat B, Gautier N, Enjalbert, Krantic S. Somatostatin increases mitogen-induced IL-2 secretion and proliferation of human Jurkat T cells via sst3 receptor isotype. Journal of Cellular Biochemistry 1998;68(1):62–73.

    Article  CAS  PubMed  Google Scholar 

  67. van Hagen PM, Hofland LJ, ten Bokum AM, Lichtenauer-Kaligis EG, Kwekkeboom DJ, Ferone D, Lamberts SW. Neuropeptides and their receptors in the immune system. Annals of Medicine 1999;31Suppl 2:15–22.

    PubMed  Google Scholar 

  68. Vanhagen PM, Krenning EP, Reubi JC, Kwekkeboom DJ, Bakker WH, Mulder, AH, Laissue I, Hoogstede HC, Lamberts SW. Somatostatin analogue scintigraphy in granulomatous diseases. European Journal of Nuclear Medicine 1994;21(6):497–502.

    Article  CAS  PubMed  Google Scholar 

  69. Ozturk E, Gunalp B, Ozguven M, Ozkan S, Sipit T, Narin Y, Bayhan H. The visualization of granulomatous disease with somatostatin receptor scintigraphy. Clinical Nuclear Medicine 1994; 19(2): 129–32.

    CAS  PubMed  Google Scholar 

  70. Vanhagen PM, Markusse HM, Lamberts SW, Kwekkeboom DJ, Reubi JC, Krenning EP. Somatostatin receptor imaging. The presence of somatostatin receptors in rheumatoid arthritis. Arthritis & Rheumatism 1994;37(10): 1521–7.

    CAS  Google Scholar 

  71. Postema PT, Kwekkeboom DJ, van Hagen PM, Krenning EP. Somatostatin-receptor scintigraphy in Graves’ orbitopathy. European Journal of Nuclear Medicine 1996;23(6):615–7.

    Article  CAS  PubMed  Google Scholar 

  72. Kwekkeboom DJ, Krenning EP, Kho GS, Breeman WA, van Hagen PM. Somatostatin receptor imaging in patients with sarcoidosis. European Journal of Nuclear Medicine 1998;25(9):1284–92.

    CAS  PubMed  Google Scholar 

  73. Reubi JC, Waser B, van Hagen M, Lamberts SW, Krenning EP, Gebbers JO, Laissue JA. In vitro and in vivo detection of somatostatin receptors in human malignant lymphomas. International Journal of Cancer 1992;50(6):895–900.

    CAS  Google Scholar 

  74. John M, Meyerhof W, Richter D, Waser B, Schaer JC, Scherubl H, Boese-Landgraf J, Neuhaus P, Ziske C, Molling K, et al. Positive somatostatin receptor scintigraphy correlates with the presence of somatostatin receptor subtype 2. Gut 1996;38(1):33–9.

    CAS  PubMed  Google Scholar 

  75. Bowman MA, Campbell L, Darrow BL, Ellis TM, Suresh A, Atkinson MA. Immunological and metabolic effects of prophylactic insulin therapy in the NOD-scid/scid adoptive transfer model of IDDM. Diabetes 1996;45(2):205–8.

    CAS  PubMed  Google Scholar 

  76. Matucci-Cerinic M, Borrelli F, Generini S, Cantelmo A, Marcucci I, Martelli F, Romagnoli P, Bacci S, Conz A, Marinelli P. Somatostatin-induced modulation of inflammation in experimental arthritis. Arthritis & Rheumatism 1995;38(11): 1687–93.

    CAS  Google Scholar 

  77. Eliakim R, Karmeli F, Okon E, Rachmilewitz D. Octreotide effectively decreases mucosal damage in experimental colitis. Gut 1993;34(2):264–9.

    CAS  PubMed  Google Scholar 

  78. Lamrani A, Tulliez M, Chauvelot-Moachon L, Chaussade S, Mauprivez C, Hagnere AM, Vidon N. Effects of octreotide treatment on early TNF-alpha production and localization in experimental chronic colitis. Alimentary Pharmacology & Therapeutics 1999;13(5):583–94.

    CAS  Google Scholar 

  79. Coari G, Di Franco M, Iagnocco A, Di Novi MR, Mauceri MT, Ciocci A. Intra-articular somatostatin 14 reduces synovial thickness in rheumatoid arthritis: an ultrasonographic study. International Journal of Clinical Pharmacology Research 1995;15(1):27–32.

    CAS  PubMed  Google Scholar 

  80. Fioravanti A, Govoni M, La Montagna G, Perpignano G, Tirri G, Trotta, Bogliolo A, Ciocci A, Mauceri MT, Marcolongo R. Somatostatin 14 and joint inflammation: evidence for intraarticular efficacy of prolonged administration in rheumatoid arthritis. Drugs Under Experimental & Clinical Research 1995;21(3):97–103.

    CAS  Google Scholar 

  81. Cortot A, Dupas JL, Colombel JF, Canva JY, Rigaud D, Gehenot M, Deschamps V, and Bonfils S. Vapreotide (Octastatine, RC 160) in the treatment of acute Crohn’s disease (CD). Gut 1994;35F285

    Google Scholar 

  82. Weber G, Klughardt G, Neidhardt M, Galle K, Frey H, Geiger A. Treatment of psoriasis with somatostatin. Archives of Dermatological Research 1982;272(1–2):31–6.

    CAS  PubMed  Google Scholar 

  83. Guilhou JJ, Boulanger A, Barneon G, Vic P, Meynadier J, Tardieu JC, Clot J. Somatostatin treatment of psoriasis. Archives of Dermatological Research 1982;274(3–4):249–57.

    CAS  PubMed  Google Scholar 

  84. Matucci-Cerinic M, Lotti T, Cappugi P, Boddi V, Fattorini L, Panconesi E. Somatostatin treatment of psoriatic arthritis. International Journal of Dermatology 1988;27(1):56–8.

    CAS  PubMed  Google Scholar 

  85. Venier A, De Simone C, Forni L, Ghirlanda G, Uccioli L, Serri F, Frati L. Treatment of severe psoriasis with somatostatin: four years of experience. Archives of Dermatological Research 1988;280 Suppl:S51–S54

    PubMed  Google Scholar 

  86. Camisa C, O’Dorisio TM, Maceyko RF, Schacht GE, Mekhjian HS, Howe BA. Treatment of psoriasis with chronic subcutaneous administration of somatostatin analog 201-995 (sandostatin). I. An open-label pilot study. Cleveland Clinic Journal of Medicine 1990;57(1):71–6.

    CAS  PubMed  Google Scholar 

  87. Krassas GE, Kaltsas T, Dumas A, Pontikides N, Tolis G. Lanreotide in the treatment of patients with thyroid eye disease. European Journal of Endocrinology 1997;136(4):416–22.

    CAS  PubMed  Google Scholar 

  88. Buscail L, Delesque N, Esteve JP, Saint-Laurent N, Prats H, Clerc P, Robberecht P, Bell GI, Liebow C, Schally AV. Stimulation of tyrosine phosphatase and inhibition of cell proliferation by somatostatin analogues: mediation by human somatostatin receptor subtypes SSTR1 and SSTR2. Proc. Natl. Acad. Sci. USA 1994;91(6):2315–9.

    CAS  PubMed  Google Scholar 

  89. Dent P, Wang Y, Gu YZ, Wood SL, Reardon DB, Mangues R, Pellicer A, Schonbrunn A, Sturgill TW. S49 cells endogenously express subtype 2 somatostatin receptors which couple to increase protein tyrosine phosphatase activity in membranes and down-regulate Raf-1 activity in situ. Cellular Signalling 1997;9(7):539–49.

    Article  CAS  PubMed  Google Scholar 

  90. Lopez F, Esteve JP, Buscail L, Delesque N, Saint-Laurent N, Theveniau, Nahmias C, Vaysse N, Susini C. The tyrosine phosphatase SHP-1 associates with the sst2 somatostatin receptor and is an essential component of sst2-mediated inhibitory growth signaling. J. Biol. Chem. 1997;272(39):24448–54.

    Article  CAS  PubMed  Google Scholar 

  91. Alberola-Ila J, Takaki S, Kerner JD, Perlmutter RM. Differential signaling by lymphocyte antigen receptors. Annual Review of Immunology 1997;15:125–54.

    Article  CAS  PubMed  Google Scholar 

  92. Plas DR, Johnson R, Pingel JT, Matthews RJ, Dalton M, Roy G, Chan, AC, Thomas ML. Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling. Science 1996;272(5265):1173–6.

    CAS  PubMed  Google Scholar 

  93. Pani G, Fischer KD, Mlinaric-Rascan I, Siminovitch KA. Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase. Journal of Experimental Medicine 1996;184(3):839–52.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. College of Medicine, Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA

    David E. Elliott M.D., Ph.D.

Authors
  1. David E. Elliott M.D., Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Medicine, McGill University Heath Center, Montréal, Québec, Canada

    Coimbatore B. Srikant

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Springer Science + Business Media, Inc.

About this chapter

Cite this chapter

Elliott, D.E. (2004). Expression and Function of Somatostatin and its Receptors in Immune Cells. In: Srikant, C.B. (eds) Somatostatin. Endocrine Updates, vol 24. Springer, Boston, MA. https://doi.org/10.1007/1-4020-8033-6_11

Download citation

  • DOI: https://doi.org/10.1007/1-4020-8033-6_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4020-7799-9

  • Online ISBN: 978-1-4020-8033-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation