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Nuclear Factor-κB Activation Mediates Cellular Transformation, Proliferation, Invasion Angiogenesis and Metastasis of Cancer

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Molecular Targeting and Signal Transduction

Part of the book series: Cancer Treatment and Research ((CTAR,volume 119))

Conclusions

Overall these studies clearly demonstrate that NF-κB plays a critical role in tumorigenesis. Similarity, suppression of NF-κB has the ability to inhibit various steps in the tumorigenic process. Design of inhibitors that are pharmacologically safe will be critical for the treatment of cancer. Because of the multiple agents that activate NF-κB through diverse pathways, it is unlikely that any single inhibitor of NF-κB would be effective against all tumors.

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  1. Department of Bioimmunotherapy, The University of Texas M. D. Anderson Cancer Center, Houston, Texas

    Shishir Shishodia & Bharat B. Aggarwal

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  1. Shishir Shishodia
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  1. M. D. Anderson Cancer Center, The University of Texas, Houston, TX, USA

    Rakesh Kumar Ph.D.

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Shishodia, S., Aggarwal, B.B. (2004). Nuclear Factor-κB Activation Mediates Cellular Transformation, Proliferation, Invasion Angiogenesis and Metastasis of Cancer. In: Kumar, R. (eds) Molecular Targeting and Signal Transduction. Cancer Treatment and Research, vol 119. Springer, Boston, MA. https://doi.org/10.1007/1-4020-7847-1_8

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