This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Hasegawa, P.M., Bressan, R.A., Zhu, J.K. and Bohnert, H.J. (2000) Plant cellular and molecular responses to high salinity. Annu. Rev. Plant Physiol. Plant Mol. Biol. 51, 463-499.
Ramanjulu, S. and Bartels, D. (2002) Drought-and desiccation-induced modulation of gene expression in plants. Plant Cell Environ. 25, 141-151.
Bohnert, H.J. and Cushman, J.C. (2002) Plants and environmental stress adaptation strategies. In: Plant Biotechnology and Transgenic Plants (Barz, M. and Oksman-Kaldentey, D., eds). New York : Marcel Dekker, pp. 635-664.
Lucht, J.M. and Bremer, E. (1994) Adaptation of Escherichia coli to high osmolarity environments: osmoregulation of the high-affinity glycine betaine transport system proU. FEMS Microbiol. Rev. 14, 3-20.
Hanson, A.D., Rathinasabapathi, B., Rivoal, J., Burnet, M., Dillon, M.O. and Gage, D.A. (1994) Osmoprotective compounds in the Plumbaginaceae: a natural experiment in metabolic engineering of stress tolerance. Proc. Natl. Acad. Sci. USA 91, 306-310.
McNeil, S.D., Nuccio, M.L. and Hanson, A.D. (1999) Betaines and related osmoprotectants. Targets for metabolic engineering of stress resistance. Plant Physiol. 120, 945-950.
Weretilnyk, E.A. and Hanson, A.D. (1990) Molecular cloning of a plant betaine-aldehyde dehydrogenase, an enzyme implicated in adaptation to salinity and drought. Proc. Natl. Acad. Sci. USA 87, 2745-2749.
Rathinasabapathi, B., Burnet, M., Russell, B.L., Gage, D.A., Liao, P.C., Nye, G.J., Scott, P., Golbeck, J.H. and Hanson, A.D. (1997) Choline monooxygenase, an unusual iron-sulfur enzyme catalyzing the first step of glycine betaine synthesis in plants: prosthetic group characterization and cDNA cloning. Proc. Natl. Acad. Sci. USA 94, 3454-3458.
Waditee, R., Tanaka, Y., Aoki, K., Hibino, T., Jikuya, H., Takano, J., Takabe, T. and Takabe, T. (2003) Isolation and functional characterization of N-methyltransferases that catalyze betaine synthesis from glycine in a halotolerant photosynthetic organism Aphanothece halophytica. J. Biol. Chem. 278, 4932-4942.
Bolen, D.W. and Baskakov, I.V. (2001) The osmophobic effect: natural selection of a thermodynamic force in protein folding. J. Mol. Biol. 310, 955-963.
Poolman, B., Spitzer, J.J. and Wood, J.M. (2004) Bacterial osmosensing: roles of membrane structure and electrostatics in lipid-protein and protein-protein interactions. Biochim. Biophys. Acta 1666, 88-104.
Kramer, R. and Morbach, S. (2004) BetP of Corynebacterium glutamicum, a transporter with three different functions: betaine transport, osmosensing, and osmoregulation. Biochim. Biophys. Acta 1658, 31-36.
Nuccio, M.L., Rhodes, D., McNeil, S.D. and Hanson, A.D. (1999) Metabolic engineering of plants for osmotic stress resistance. Curr Opin Plant Biol. 2,128-134.
Rontein, D., Basset, G., and Hanson, A.D. (2002) Metabolic engineering of osmoprotectant accumulation in plants. Metab. Eng. 4, 49-56.
Chen, T.H. and Murata, N. (2002) Enhancement of tolerance of abiotic stress by metabolic engineering of betaines and other compatible solutes. Curr. Opin. Plant Biol. 5, 250-257.
Sakamoto, A. and Murata, N. (2002) The role of glycine betaine in the protection of plants from stress: clues from transgenic plants. Plant Cell Environ. 25, 163-171.
Craig, S.A. (2004) Betaine in human nutrition. Am. J. Clin. Nutr. 80, 539-549.
Kempf, B. and Bremer, E. (1998) Uptake and synthesis of compatible solutes as microbial stress responses to high-osmolality environments. Arch. Microbiol. 170, 319-330.
Ishitani, M., Nakamura, T., Han, S.Y. and Takabe T. (1995) Expression of the betaine aldehyde dehydrogenase gene in barley in response to osmotic stress and abscisic acid. Plant Mol. Biol. 27, 307-315.
Perrino, L.A. and Pierce, S.K. (2000) Choline dehydrogenase kinetics contribute to glycine betaine regulation differences in chesapeake bay and atlantic oysters. J. Exp. Zool. 286, 250-261.
Perrino, L.A. and Pierce, S.K. (2000) Betaine aldehyde dehydrogenase kinetics partially account for oyster population differences in glycine betaine synthesis. J. Exp. Zool. 286, 238-249.
Lamark, T., Rokenes, T.P., McDougall, J. and Strom, A.R. (1996) The complex bet promoters of Escherichia coli: regulation by oxygen (ArcA), choline (BetI), and osmotic stress. J. Bacteriol. 178,1655-1662.
Liu, Y. and Bolen, D.W. (1995) The peptide backbone plays a dominant role in protein stabilization by naturally occurring osmolytes. Biochemistry 34, 12884-12891.
Murata, N., Mohanty, P.S., Hayashi, H. and Papageorgiou, G.C. (1992) Glycinebetaine stabilizes the association of extrinsic proteins with the photosynthetic oxygen-evolving complex. FEBS Lett. 296, 187-189.
Qu, Y., Bolen, C.L. and Bolen, D.W. (1998) Osmolyte-driven contraction of a random coil protein. Proc. Natl. Acad. Sci. USA 95, 9268-9273.
Ikuta, S., Imamura, S., Misaki, H. and Horiuti, Y. (1977) Purification and characterization of choline oxidase from Arthrobacter globiformis, J. Biochem. (Tokyo) 82, 1741-1749.
Hibino, T., Meng, Y.L., Kawamitsu, Y., Uehara, N., Matsuda, N., Tanaka, Y., Ishikawa, H., Baba, S., Takabe, T., Wada, K., Ishii, T. and Takabe, T. (2001) Molecular cloning and functional characterization of two kinds of betaine-aldehyde dehydrogenase in betaine-accumulating mangrove Avicennia marina (Forsk.) Vierh. Plant Mol. Biol. 45, 353-363.
Hibino, T., Waditee, R., Araki, E., Ishikawa, H., Aoki, K., Tanaka, Y. and Takabe T. (2002) Functional characterization of choline monooxygenase, an enzyme for betaine synthesis in plants. J Biol Chem. 277, 41352-41360.
Nakamura, T., Yokota, S., Muramoto, Y., Tsutsui, K., Oguri, Y., Fukui, K. and Takabe, T. (1997) Expression of a betaine aldehyde dehydrogenase gene in rice, a glycinebetaine nonaccumulator, and possible localization of its protein in peroxisomes. Plant J. 11, 1115-1120.
Nakamura, T., Nomura, M., Mori, H., Jagendorf, A.T., Ueda, A. and Takabe, T. (2001) An isozyme of betaine aldehyde dehydrogenase in barley. Plant Cell Physiol. 42, 1088-1092.
Trossat, C., Rathinasabapathi, B. and Hanson, A.D. (1997) Transgenically expressed betaine aldehyde dehydrogenase efficiently catalyzes oxidation of dimethylsulfoniopropionaldehyde and omega-aminoaldehydes. Plant Physiol. 113, 1457-1461.
Incharoensakdi, A., Matsuda, N., Hibino, T., Meng, Y.L., Ishikawa, H., Hara, A., Funaguma, T., Takabe, T. and Takabe, T. (2000) Overproduction of spinach betaine aldehyde dehydrogenase in Escherichia coli. Structural and functional properties of wild-type, mutants and E. coli enzymes. Eur. J. Biochem. 267, 7015-7023.
Hayashi, H., Alia., Mustardy, L., Deshnium, P., Ida, M. and Murata, N. (1997) Transformation of Arabidopsis thaliana with the codA gene for choline oxidase; accumulation of glycinebetaine and enhanced tolerance to salt and cold stress. Plant J. 12, 133-42.
McNeil, S.D., Nuccio, M.L., Ziemak, M.J. and Hanson, A.D. (2001) Enhanced synthesis of choline and glycine betaine in transgenic tobacco plants that overexpress phosphoethanolamine N-methyltransferase. Proc. Natl. Acad. Sci. USA 98, 10001-10005.
Moffatt, B.A., Stevens, Y.Y., Allen, M.S., Snider, J.D., Pereira, L.A., Todorova, M.I., Summers, P.S., Weretilnyk, E.A., Martin-McCaffrey, L. and Wagner, C. (2002) Adenosine kinase deficiency is associated with developmental abnormalities and reduced transmethylation. Plant Physiol. 128, 812-821.
Park, E.J., Jeknic, Z., Sakamoto, A., DeNoma, J., Yuwansiri, R., Murata, N. and Chen, T.H. (2004) Genetic engineering of glycinebetaine synthesis in tomato protects seeds, plants, and flowers from chilling damage. Plant J. 40, 474-487.
Jagendorf, A.T. and Takabe, T. (2001) Inducers of glycinebetaine synthesis in barley. Plant Physiol. 127, 1827-1835.
Waditee, R., Bhuiyan, M.N., Rai, V., Aoki, K., Tanaka, Y., Hibino, T., Suzuki, S., Takano, J., Jagendorf, A.T., Takabe, T. and Takabe T. (2005) Genes for direct methylation of glycine provide high levels of glycinebetaine and abiotic-stress tolerance in Synechococcus and Arabidopsis. Proc. Natl. Acad. Sci. USA 102, 1318-1323.
Schwacke, R., Grallath, S., Breitkreuz, K.E., Stransky, E., Stransky, H., Frommer, W.B. and Rentsch, D. (1999) LeProT1, a transporter for proline, glycine betaine, and gamma-amino butyric acid in tomato pollen. Plant Cell 11, 377-392.
Waditee, R., Hibino, T., Tanaka, Y., Nakamura, T., Incharoensakdi, A., Hayakawa, S., Suzuki, S., Futsuhara, Y., Kawamitsu, Y., Takabe, T. and Takabe, T. (2001) Functional characterization of betaine/proline transporters in betaine-accumulating mangrove. J. Biol. Chem. 277, 18373-18382.
Fetterer, R.H., Augustine, P.C., Allen, P.C. and Barfield, R.C. (2003) The effect of dietary betaine on intestinal and plasma levels of betaine in uninfected and coccidia-infected broiler chicks. Parasitol Res. 90, 343-348.
Fernandez-Figares, I., Wray-Cahen, D., Steele, N.C., Campbell, R.G., Hall, D.D., Virtanen, E. and Caperna, T.J. (2002) Effect of dietary betaine on nutrient utilization and partitioning in the young growing feed-restricted pig. J. Anim. Sci. 80, 421-428.
Olthof, M.R. and Verhoef, P. (2005) Effects of betaine intake on plasma homocysteine concentrations and consequences for health. Curr. Drug Metab. 6, 15-22.
Zeisel, S.H., Mar, M.H., Howe, J.C. and Holden, J.M. (2003) Concentrations of choline-containing compounds and betaine in common foods. J. Nutr. 133, 1302-1307.
Schwahn, B.C., Hafner, D., Hohlfeld, T., Balkenhol, N., Laryea, M.D. and Wendel, U. (2003) Pharmacokinetics of oral betaine in healthy subjects and patients with homocystinuria. Br. J. Clin. Pharmacol. 55, 6-13.
Lever, M., Sizeland, P.C., Bason, L.M., Hayman, C.M., Robson, R.A. and Chambers, S.T. (1994) Abnormal glycine betaine content of the blood and urine of diabetic and renal patients. Clin. Chim. Acta 230, 69-79.
Hayes, K.C., Pronczuk, A., Cook, M.W., Robbins, M.C. (2003) Betaine in sub-acute and sub-chronic rat studies. Food Chem. Toxicol. 41, 1685-1700.
Evans, J.C., Huddler, D.P., Jiracek, J., Castro, C., Millian, N.S., Garrow, T.A. and Ludwig, M.L. (2002) Betaine-homocysteine methyltransferase: zinc in a distorted barrel. Structure (Camb) 10, 1159-1171.
Park, E.I., Renduchintala, M.S., Garrow, T.A. (1997) Diet-induced changes in hepatic betaine-homocysteine methyltransferase activity are mediated by changes in steady-state levels of its mRNA. J. Nutr. Biochem. 8, 541-545.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Springer
About this chapter
Cite this chapter
TAKABE, T., RAI, V., HIBINO, T. (2006). Metabolic engineering of glycinebetaine. In: RAI, A.K., TAKABE, T. (eds) Abiotic stress tolerance in plants. Springer, Dordrecht. https://doi.org/10.1007/1-4020-4389-9_9
Download citation
DOI: https://doi.org/10.1007/1-4020-4389-9_9
Publisher Name: Springer, Dordrecht
Print ISBN: 978-1-4020-4388-8
Online ISBN: 978-1-4020-4389-5
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)