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fMRI of Language Systems: Methods and Applications

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Functional MRI

Abstract

Language functions were among the first to be ascribed a specific location in the human brain1 and have been the subject of intense research for over a century. Many researchers across the globe—working in disciplines as varied as linguistics, psychology, neurology, anthropology, and philosophy—have devoted their careers to understanding language processes and their biological bases.

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References

  1. Broca P. Remarques sur le siège de la faculté du langage articulé; suivies d’une observation d’aphemie. Bull Soc Anat Paris. 1861;6:330-357.

    Google Scholar 

  2. Loring DW, Meador KJ, Lee GP, King DW. Amobarbital Effects and Lateraized Brain Function: The Wada Test. New York: Springer-Verlag; 1992.

    Google Scholar 

  3. Lesser RP, Lueders H, Klem G, Dinner DS, Morris HH, Hahn JF, et al. Extraoperative cortical functional localization in patients with epilepsy. J Clin Neurophysiol. 1987;4:27-53.

    Google Scholar 

  4. Ojemann G, Ojemann J, Lettich E, Berger M. Cortical language localization in left, dominant hemisphere: An electrical stimulation mapping investigation in 117 patients. J Neurosurg. 1989;71:316-326.

    Google Scholar 

  5. Pardo JV, Fox PT. Preoperative assessment of the cerebral hemispheric dominance for language with CBF PET. Hum Brain Mapp. 1993;1:57-68.

    Google Scholar 

  6. Breier JI, Simos PG, Zouridakis G, Wheless JW, Willmore LJ, Constantinou JE, et al. Language dominance determined by magnetic source imaging: a comparison with the Wada procedure. Neurology. 1999;53: 938-945.

    PubMed  CAS  Google Scholar 

  7. Binder JR, Swanson SJ, Hammeke TA, Morris GL, Mueller WM, Fischer M, et al. Determination of language dominance using functional MRI: A comparison with the Wada test. Neurology. 1996;46:978-984.

    Google Scholar 

  8. Desmond JE, Sum JM, Wagner AD, Demb JB, Shear PK, Glover GH, et al. Functional MRI measurement of language lateralization in Wada-tested patients. Brain. 1995;118:1411-1419.

    Google Scholar 

  9. Bahn MM, Lin W, Silbergeld DL, Miller JW, Kuppusamy K, Cook RJ, et al. Localization of language cortices by functional MR imaging compared with intracarotid amobarbital hemispheric sedation. Am J Radiol. 1997;169:575-579.

    CAS  Google Scholar 

  10. Hertz-Pannier L, Gaillard WD, Mott S, Cuenod CA, Bookheimer S, Weinstein S, et al. Noninvasive assessment of language dominance in children and adolescents with functional MRI: a preliminary study. Neurology. 1997;48:1003-1012.

    PubMed  CAS  Google Scholar 

  11. Worthington C, Vincent DJ, Bryant AE, Roberts DR, Vera CL, Ross DA, et al. Comparison of functional magnetic resonance imaging for language localization and intracarotid speech amytal testing in presurgical evaluation for intractable epilepsy. Stereotact Funct Neurosurg. 1997;69: 197-201.

    PubMed  CAS  Google Scholar 

  12. Benbadis SR, Binder JR, Swanson SJ, Fischer M, Hammeke TA, Morris GL, et al. Is speech arrest during Wada testing a valid method for determining hemispheric representation of language? Brain Lang. 1998;65:441-446.

    PubMed  CAS  Google Scholar 

  13. Yetkin FZ, Swanson S, Fischer M, Akansel G, Morris G, Mueller W, et al. Functional MR of frontal lobe activation: Comparison with Wada language results. Am J Neuroradiol. 1998;19:1095-1098.

    PubMed  CAS  Google Scholar 

  14. Benson RR, FitzGerald DB, LeSeuer LL, Kennedy DN, Kwong KK, Buchbinder BR, et al. Language dominance determined by whole brain functional MRI in patients with brain lesions. Neurology. 1999;52: 798-809.

    PubMed  CAS  Google Scholar 

  15. Hirsch J, Ruge MI, K.H.S. K, Correa DD, Victor JD, Relkin NR, et al. An integrated functional magnetic resonance imaging procedure for pre-operative mapping of cortical areas associated with tactile, motor, language, and visual functions. Neurosurgery. 2000;47:711-722.

    Google Scholar 

  16. Lehéricy S, Cohen L, Bazin B, Samson S, Giacomini E, Rougetet R, et al. Functional MR evaluation of temporal and frontal language dominance compared with the Wada test. Neurology. 2000;54:1625-1633.

    PubMed  Google Scholar 

  17. Spreer J, Quiske A, Altenmüller DM, Arnold S, Schulze-Bonhage A, Steinhoff BJ, et al. Unsuspected atypical hemispheric dominance for language as determined by fMRI. Epilepsia. 2001;52:957-959.

    Google Scholar 

  18. Liégois F, Connelly A, Salmond CH, Gadian DG, Vargha-Khadem F, Baldeweg T. A direct test for lateralization of language activation using fMRI: Comparison with invasive assessments in children with epilepsy. Neuroimage. 2002;17:1861-1867.

    Google Scholar 

  19. Spreer J, Arnold S, Quiske A, Ziyeh S, Altenmüller DM, Herpers M, et al. Determination of hemisphere dominance for language: comparison of frontal and temporal fMRI activation with intracarotid amytal testing. Neuroradiology. 2002;44:467-474.

    PubMed  CAS  Google Scholar 

  20. Adcock JE, Wise RG, Oxbury JM, Oxbury SM, Matthews PM. Quantitative fMRI assessment of the differences in lateralization of language related brain activation in patients with temporal lobe epilepsy.Neuroimage. 2003;18:423-438.

    PubMed  CAS  Google Scholar 

  21. Sabbah P, Chassoux F, Leveque C, Landre E, Baudoin-Chial S, evaux B, et al. Functional MR imaging in assessment of language dominance in epileptic patients. Neuroimage. 2003;18:460-467.

    CAS  Google Scholar 

  22. Rutten G-J, Ramsey N, van Rijen P, Alpherts W, van Veelen C. fMRI-determined language lateralization in patients with unilateral or mixed language dominance according to the Wada test. Neuroimage. 2002;17: 447-460.

    PubMed  CAS  Google Scholar 

  23. Fitzgerald DB, Cosgrove GR, Ronner S, Jiang H, Buchbinder BR, Belliveau JW, et al. Location of language in the cortex: A comparison between functional MR imaging and electrocortical stimulation. Am J Neuroradiol. 1997;18:1529-1539.

    PubMed  CAS  Google Scholar 

  24. Stapleton SR, Kiriakipoulos E, Mikulis D, Drake JM, Hoffman HJ, Humphreys R, et al. Combined utility of functional MRI, cortical mapping, and frameless stereotaxy in the resection of lesions in eloquent areas of brain in children. Pediatr Neurosurg. 1997;26:68-82.

    PubMed  CAS  Google Scholar 

  25. Yetkin FZ, Mueller WM, Morris GL, McAuliffe TL, Ulmer JL, Cox RW, et al. Functional MR activation correlated with intraoperative cortical mapping. Am J Neuroradiol. 1997;18:1311-1315.

    PubMed  CAS  Google Scholar 

  26. Ruge MI, Victor JD, Hosain S, Correa DD, Relkin NR, Tabar V, et al. Con-cordance between functional magnetic resonance imaging and intraoperative language mapping. Stereotact Funct Neurosurg. 1999;72:95-102.

    PubMed  CAS  Google Scholar 

  27. Schlosser MJ, Luby M, Spencer DD, Awad IA, McCarthy G. Comparative localization of auditory comprehension by using functional magnetic resonance imaging and cortical stimulation. J Neurosurg. 1999;91:626-635.

    PubMed  CAS  Google Scholar 

  28. Lurito JT, Lowe MJ, Sartorius C, Mathews VP. Comparison of fMRI and intraoperative direct cortical stimulation in localization of receptive language areas. J Comput Assist Tomogr. 2000;24:99-105.

    PubMed  CAS  Google Scholar 

  29. Rutten GJM, van Rijen PC, van Veelen CWM, Ramsey NF. Language area localization with three-dimensional functional magnetic resonance imaging matches intrasulcal electrostimulation in Broca’s area. Ann Neurol. 1999;46:405-408.

    PubMed  CAS  Google Scholar 

  30. Rutten GJM, Ramsey NF, van Rijen PC, Noordmans HJ, van Veelen CW. Development of a functional magnetic resonance imaging protocol for intraoperative localization of critical temporoparietal language areas. Ann Neurol. 2002;51:350-360.

    PubMed  CAS  Google Scholar 

  31. Rutten GJ, Ramsey N, van Rijen P, van Veelen C. Reproducibility of fMRI-determined language lateralization in individual subjects. Brain Lang. 2002;80:421-437.

    PubMed  CAS  Google Scholar 

  32. Sabsevitz DS, Swanson SJ, Hammeke TA, Spanaki MV, Possing ET, Morris GL, et al. Use of preoperative functional neuroimaging to predict language deficits from epilepsy surgery. Neurology. 2003;60:1788-1792.

    PubMed  CAS  Google Scholar 

  33. Binder J. FMRI: Language mapping. Neurosurg Clin N Am. 1997;8:383-392.

    PubMed  CAS  Google Scholar 

  34. Gaillard WD, Theodore WH. Mapping language in epilepsy with functional neuroimaging. Neuroscientist. 2000;6:391-401.

    Google Scholar 

  35. Hammeke TA, Bellgowan PSF, Binder JR. FMRI methodology: Cognitive function mapping. Adv Neurol. 2000;83:221-233.

    PubMed  CAS  Google Scholar 

  36. Detre JA, Floyd TF. Functional MRi and its applications to the clinical neurosciences. Neuroscientist. 2001;7:64-79.

    PubMed  CAS  Google Scholar 

  37. Binder JR, Achten E, Constable RT, Detre JA, Gaillard WD, Jack CR, et al. Functional MRI in epilepsy. Epilepsia. 2002;43 (Suppl 1):51-63.

    Google Scholar 

  38. Carpentier A, Pugh KR, Westerveld M, et al. Functional MRI of language processing: dependence on input modality and temporal lobe epilepsy. Epilepsia. 2001;42:1241-1254.

    PubMed  CAS  Google Scholar 

  39. Fernández G, Specht K, Weis S, Tendolkar I, Reuber M, Fell J, et al. Intrasubject reproducibility of presurgical language lateralization and mapping using fMRI. Neurology. 2003;60:969-975.

    PubMed  Google Scholar 

  40. Kertesz A, Harlock W, Coates R. Computer tomographic localization, lesion size, and prognosis in aphasia and nonverbal impairment. Brain Lang. 1979;8:34-50.

    PubMed  CAS  Google Scholar 

  41. Porch BE, Collins M, Wertz RT, Friden TP. Statistical prediction of change in aphasia. J Speech Hear Res. 1980;23:312-321.

    PubMed  CAS  Google Scholar 

  42. Selnes OA, Knopman DS, Niccum N, Rubens AB, Larson D. Computed tomographic scan correlates of auditory comprehension deficits in aphasia: A prospective recovery study. Ann Neurol. 1983;13:558-566.

    PubMed  CAS  Google Scholar 

  43. Metter EJ, Jackson CA, Kempler D, Hanson WR. Temporoparietal cortex and the recovery of language comprehension in aphasia. Aphasiology. 1992;6:349-358.

    Google Scholar 

  44. Ferro JM. The influence of infarct location on recovery from global aphasia. Aphasiology. 1992;6:415-430.

    Google Scholar 

  45. Code C, Rowley D, Kertesz A. Predicting recovery from aphasia with connectionist networks: Preliminary comparisons with multiple regression. Cortex. 1994;30:527-532.

    PubMed  CAS  Google Scholar 

  46. Karbe H, Kessler J, Herholz K, Fink GR, Heiss W-D. Long-term prognosis of poststroke aphasia studied with positron emission tomography Arch Neurol. 1995;52:186-190.

    CAS  Google Scholar 

  47. Pedersen PM, Jorgensen HS, Nakayama H, Raaschou HO, Olsen TS. Aphasia in acute stroke: Incidence, determinants, and recovery. Ann Neurol. 1995;38:659-666.

    PubMed  CAS  Google Scholar 

  48. Cao Y, Vikingstad BS, George PK, Johnson AF, Welch KMA. Cortical language activation in stroke patients recovering from aphasia with functional MRI. Stroke. 1999;30:2331-2340.

    PubMed  CAS  Google Scholar 

  49. Thulborn KR, Carpenter PA, Just MA. Plasticity of language-related brain function during recovery from stroke. Stroke. 1999;30:749-754.

    PubMed  CAS  Google Scholar 

  50. Calvert GA, Brammer MJ, Morris RG, Williams SCR, King N, Matthews PM. Using fMRI to study recovery from acquired dysphasia. Brain Lang. 2000;71:391-399.

    PubMed  CAS  Google Scholar 

  51. Rosen HJ, Petersen SE, Linenweber MR, Snyder AZ, White DA, Chapman L, et al. Neural correlates of recovery from aphasia after damage to left inferior frontal cortex. Neurology. 2000;55:1883-1894.

    PubMed  CAS  Google Scholar 

  52. Eden GF, VanMeter JW, Rumsey JM, Maisog JM, Woods RP, Zeffiro TA.Abnormal processing of visual motion in dyslexia revealed by functional brain imaging. Nature. 1996;382:66-69.

    PubMed  CAS  Google Scholar 

  53. Demb JB, Boynton GM, Heeger DJ. Brain activity in visual cortex predicts individual differences in reading performance. PNAS. 1997;94: 13363-13366.

    PubMed  CAS  Google Scholar 

  54. Shaywitz SE, Shaywitz BA, Pugh KR, Fulbright RK, Constable RT, Mencl WE, et al. Functional disruption in the organization of the brain for reading in dyslexia. PNAS. 1998;95:2636-2641.

    PubMed  CAS  Google Scholar 

  55. Temple E, Deutsch GK, Poldrack RA, Miller SL, Tallal P, Merzenich MM, et al. Neural deficits in children with dyslexia ameliorated by behavioral remediation: Evidence from functional MRI. PNAS. 2003;100:2860-2865.

    PubMed  CAS  Google Scholar 

  56. Petersen SE, Fox PT, Posner MI, Mintun M, Raichle ME. Positron emission tomographic studies of the cortical anatomy of single-word processing. Nature. 1988;331:585-589.

    PubMed  CAS  Google Scholar 

  57. Wise R, Chollet F, Hadar U, Friston K, Hoffner E, Frackowiak R. Distribution of cortical neural networks involved in word comprehension and word retrieval. Brain. 1991;114:1803-1817.

    PubMed  Google Scholar 

  58. Démonet J-F, Chollet F, Ramsay S, Cardebat D, Nespoulous J-L, Wise R, et al. The anatomy of phonological and semantic processing in normal subjects. Brain. 1992;115:1753-1768.

    PubMed  Google Scholar 

  59. Binder JR, Price CJ. Functional imaging of language. In: Cabeza R, Kingstone A, editors. Handbook of Functional Neuroimaging of Cognition. Cambridge, MA: MIT Press; 2001:187-251.

    Google Scholar 

  60. Macleod CM. Half a century of research on the Stroop effect: an integrative review. Psychol Bull. 1991;109:163-203.

    PubMed  CAS  Google Scholar 

  61. Reicher GM. Perceptual recognition as a function of meaningfulness of stimulus material. J Exp Psychol. 1969;81:274-280.

    Google Scholar 

  62. Warren RM, Obusek CJ. Speech perception and phonemic restorations.Percept Psychophys. 1971;9:358-362.

    Google Scholar 

  63. Ganong WF. Phonetic categorization in auditory word perception. J Exp Psychol Hum Percept Perform. 1980;6:110-115.

    PubMed  Google Scholar 

  64. Marslen-Wilson WD, Tyler LK. Central processes in speech understanding. Philos Trans R Soc London B Biol Sci. 1981;295:317-332.

    Google Scholar 

  65. Carr TH, McCauley C, Sperber RD, Parmalee CM. Words, pictures, and priming: On semantic activation, conscious identification, and the automaticity of information processing. J Exp Psychol Hum Percept Perform. 1982;8:757-777.

    PubMed  CAS  Google Scholar 

  66. Marcel AJ. Conscious and unconscious perception: Experiments on visual masking and word recognition. Cognit Psychol. 1983;15:197-237.

    Google Scholar 

  67. Van Orden GC. A ROWS is a ROSE: Spelling, sound, and reading. Mem Cognit. 1987;15:181-198.

    Google Scholar 

  68. Burton MW, Baum SR, Blumstein SE. Lexical effects on phonetic categorization of speech: The role of acoustic structure. J Exp Psychol Hum Percept Perform. 1989;15:567-575.

    PubMed  CAS  Google Scholar 

  69. Glaser WR. Picture naming. Cognition. 1992;42:61-105.

    PubMed  CAS  Google Scholar 

  70. Raichle ME, Fiez JA, Videen TO, MacLeod AM, Pardo JV, Fox PT, et al. Practice-related changes in human brain functional anatomy during nonmotor learning. Cereb Cortex. 1994;4:8-26.

    PubMed  CAS  Google Scholar 

  71. Buckner RL, Raichle ME, Petersen SE. Dissociation of human prefrontal cortical areas across different speech production tasks and gender groups. J Neurosci. 1995;74:2163-2173.

    CAS  Google Scholar 

  72. Bookheimer SY, Zeffiro TA, Blaxton T, Gaillard T, Theodore W. Regional cerebral blood flow during object naming and word reading. Hum Brain Mapp. 1995;3:93-106.

    Google Scholar 

  73. Price CJ, Wise RSJ, Frackowiak RSJ. Demonstrating the implicit processing of visually presented words and pseudowords. Cereb Cortex. 1996;6:62-70.

    PubMed  CAS  Google Scholar 

  74. Damasio H, Grabowski TJ, Tranel D, Hichwa RD, Damasio AR. A neural basis for lexical retrieval. Nature. 1996;380:499-505.

    PubMed  CAS  Google Scholar 

  75. Binder JR, Frost JA, Hammeke TA, Cox RW, Rao SM, Prieto T. Human brain language areas identified by functional MRI. J Neurosci. 1997;17: 353-362.

    PubMed  CAS  Google Scholar 

  76. James W. Principles of Psychology, vol. 1. New York: Dover Publications; 1890.

    Google Scholar 

  77. Hebb DO. The problem of consciousness and introspection. In: Adrian ED, Bremer F, Jasper HH, editors. Brain Mechanisms and Consciousness: A Symposium. Springfield, IL: Charles C. Thomas; 1954:402-421.

    Google Scholar 

  78. Miller GA, Galanter E, Pribram K. Plans and the Structure of Behavior. New York: Holt; 1960.

    Google Scholar 

  79. Pope KS, Singer JL. Regulation of the stream of consciousness: Toward a theory of ongoing thought. In: Schwartz GE, Shapiro D, editors. Consciousness and Self-Regulation. New York: Plenum Press; 1976:101-135.

    Google Scholar 

  80. Antrobus JS, Singer JL, Greenberg S. Studies in the stream of consciousness: Experimental enhancement and suppression of spontaneous cognitive processes. Percept Mot Skills. 1966;23:399-417.

    Google Scholar 

  81. Teasdale JD, Proctor L, Lloyd CA, Baddeley AD. Working memory and stimulus-independent thought: Effects of memory load and presentation rate. Eur J Cogn Psychol. 1993;5:417-433.

    Google Scholar 

  82. Révész G, editor. Thinking and Speaking: A symposium. Amsterdam: North Holland Publishing; 1954.

    Google Scholar 

  83. Weiskrantz L, editor. Thought without Language. Oxford: Clarendon; 1988.

    Google Scholar 

  84. Vygotsky LS. Thought and Language. New York: Wiley; 1962.

    Google Scholar 

  85. Karmiloff-Smith A. Beyond Modularity: A Developmental Perspective on Cognitive Science. Cambridge, MA: MIT Press; 1992.

    Google Scholar 

  86. Andreasen NC, O’Leary DS, Cizadlo T, Arndt S, Rezai K, Watkins GL, et al. Remembering the past: Two facets of episodic memory explored with positron emission tomography. Am J Psychiatry 1995;152:1576-1585.

    PubMed  CAS  Google Scholar 

  87. Shulman GL, Fiez JA, Corbetta M, Buckner RL, Meizin FM, Raichle ME, et al. Common blood flow changes across visual tasks: II. Decreases in cerebral cortex. J Cogn Neurosci. 1997;9:648-663.

    Google Scholar 

  88. Binder JR, Frost JA, Hammeke TA, Bellgowan PSF, Rao SM, Cox RW. Conceptual processing during the conscious resting state: a functional MRI study. J Cogn Neurosci. 1999;11:80-93.

    PubMed  CAS  Google Scholar 

  89. Mazoyer B, Zago L, Mellet E, Bricogne S, Etard O, Houdé O, et al. Cortical networks for working memory and executive functions sustain the conscious resting state in man. Brain Res Bull. 2001;54:287-298.

    PubMed  CAS  Google Scholar 

  90. Raichle ME, McLeod AM, Snyder AZ, Powers WJ, Gusnard DA, Shulman GL. A default mode of brain function. PNAS. 2001;98:676-682.

    PubMed  CAS  Google Scholar 

  91. Stark CE, Squire LR. When zero is not zero: The problem of ambiguous baseline conditions in fMRI. PNAS. 2001;98:12760-12766.

    PubMed  CAS  Google Scholar 

  92. McKiernan KA, Kaufman JN, Kucera-Thompson J, Binder JR. A parametric manipulation of factors affecting task-induced deactivation in functional neuroimaging. J Cogn Neurosci. 2003;15:394-408.

    PubMed  Google Scholar 

  93. Grabowski TJ, Damasio AR. Investigating language with functional neuroimaging. In: Toga AW, Mazziotta JC, editors. Brain Mapping: The Systems. San Diego, CA: Academic Press; 2000:425-461.

    Google Scholar 

  94. Binder JR. Wernicke aphasia: A disorder of central language processing. In: D’Esposito ME, editor. Neurological Foundations of Cognitive Neuro-science. Cambridge, MA: MIT Press; 2002:175-238.

    Google Scholar 

  95. Binder JR, Frost JA, Hammeke TA, Bellgowan PSF, Springer JA, Kaufman JN, et al. Human temporal lobe activation by speech and nonspeech sounds. Cereb Cortex. 2000;10:512-528.

    PubMed  CAS  Google Scholar 

  96. Scott SK, Blank C, Rosen S, Wise RJS. Identification of a pathway for intelligible speech in the left temporal lobe. Brain.2000;123:2400-2406.

    PubMed  Google Scholar 

  97. Liebenthal E, Binder JR, Piorkowski RL, Remez RE. Short-term reorganization of auditory analysis induced by phonetic experience. J Cogn Neurosci. 2003;15:549-558.

    PubMed  Google Scholar 

  98. Belin P, Zatorre RJ, Ahad P. Human temporal-lobe response to vocal sounds. Cogn Brain Res. 2002;13:17-26.

    Google Scholar 

  99. Cohen L, Lehéricy S, Chochon F, Lemer C, Rivaud S, Dehaene S.Language-specific tuning of visual cortex? Functional properties of the visual word form area. Brain. 2002;125:1054-1069.

    PubMed  Google Scholar 

  100. Wise RSJ, Scott SK, Blank SC, Mummery CJ, Murphy K, Warburton EA.Separate neural subsystems within “Wernicke’s area”. Brain. 2001;124:83-95.

    PubMed  CAS  Google Scholar 

  101. Mazoyer BM, Tzourio N, Frak V, Syrota A, Murayama N, Levrier O, et al. The cortical representation of speech. J Cogn Neurosci. 1993;5:467-479.

    Google Scholar 

  102. Price CJ, Wise RJS, Warburton EA, Moore CJ, Howard D, Patterson K, et al. Hearing and saying. The functional neuro-anatomy of auditory word processing. Brain. 1996;119:919-931.

    Google Scholar 

  103. Zatorre RJ, Evans AC, Meyer E, Gjedde A. Lateralization of phonetic and pitch discrimination in speech processing. Science. 1992;256:846-849.

    Google Scholar 

  104. Mummery CJ, Ashburner J, Scott SK, Wise RJS. Functional neuroimaging of speech perception in six normal and two aphasic subjects. J Acoust Soc Am. 1999;106:449-457.

    PubMed  CAS  Google Scholar 

  105. Belin P, Zatorre RJ, Lafaille P, Ahad P, Pike B. Voice-selective areas in human auditory cortex. Nature. 2000;403:309-312.

    PubMed  CAS  Google Scholar 

  106. Binder JR, Rao SM, Hammeke TA, Frost JA, Bandettini PA, Hyde JS. Effects of stimulus rate on signal response during functional magnetic resonance imaging of auditory cortex. Cogn Brain Res. 1994;2:31-38.

    Google Scholar 

  107. Eulitz C, Elbert T, Bartenstein P, Weiller C, Müller SP, Pantev C. Comparison of magnetic and metabolic brain activity during a verb generation task. Neuroreport. 1994;6:97-100.

    Google Scholar 

  108. Warburton E, Wise RJS, Price CJ, Weiller C, Hadar U, Ramsay S, et al. Noun and verb retrieval by normal subjects. Studies with PET. Brain. 1996;119:159-179.

    Google Scholar 

  109. Ojemann JG, Buckner RL, Akbudak E, Snyder AZ, Ollinger JM, McKinstry RC, et al. Functional MRI studies of word-stem completion: Reliability across laboratories and comparison to blood flow imaging with PET. Hum Brain Mapp. 1998;6:203-215.

    PubMed  CAS  Google Scholar 

  110. Palmer ED, Rosen HJ, Ojemann JG, Buckner RL, Kelley WM, Petersen SE. An event-related fMRI study of overt and covert word stem completion. Neuroimage. 2001;14:182-193.

    PubMed  CAS  Google Scholar 

  111. Thompson-Schill SL, D’Esposito M, Kan IP. Effects of repetition and competition on activity in left prefrontal cortex during word generation. Neuron. 1999;23:513-522.

    PubMed  CAS  Google Scholar 

  112. Malach R, Reppas JB, Benson RR, Kwong KK, Jiang H, Kennedy WA, et al. Object-related activity revealed by functional magnetic resonance imaging in human occipital cortex. PNAS. 1995;92:8135-8139.

    PubMed  CAS  Google Scholar 

  113. Kanwisher N, Woods R, Iacoboni M, Mazziotta J. A locus in human extrastriate cortex for visual shape analysis. J Cogn Neurosci. 1996;91:133-142.

    Google Scholar 

  114. Grill-Spector K, Kushnir T, Edelman S, Avidian-Carmel G, Itzchak Y, Malach R. Differential processing of objects under various viewing conditions in the human lateral occipital complex. Neuron. 1999;24:187-203.

    PubMed  CAS  Google Scholar 

  115. Martin A, Wiggs CL, Ungerleider LG, Haxby JV. Neural correlates of category-specific knowledge. Nature. 1996;379:649-652.

    PubMed  CAS  Google Scholar 

  116. Price CJ, Moore CJ, Humphreys GW, Frackowiak RSJ, Friston KJ. The neural regions sustaining object recognition and naming. Proc R Soc London B. 1996;263:1501-1507.

    CAS  Google Scholar 

  117. Zelkowicz BJ, Herbster AN, Nebes RD, Mintun MA, Becker JT. An examination of regional cerebral blood flow during object naming tasks. J Int Neuropsychol Soc. 1998;4:160-166.

    PubMed  CAS  Google Scholar 

  118. Murtha S, Chertkow H, Beauregard M, Evans A. The neural substrate of picture naming. J Cogn Neurosci. 1999;11:399-423.

    PubMed  CAS  Google Scholar 

  119. Kiasawa M, Inoue C, Kawasaki T, Tokoro T, Ishii K, Ohyama M, et al. Functional neuroanatomy of object naming: A PET study. Graefes Arch Clin Exp Ophthalmol. 1996;234:110-115.

    Google Scholar 

  120. Vandenberghe R, Price C, Wise R, Josephs O, Frackowiak RSJ. Functional anatomy of a common semantic system for words and pictures. Nature. 1996;383:254-256.

    PubMed  CAS  Google Scholar 

  121. Müller R-A, Kleinhans N, Courchesne E. Linguistic theory and neuroimaging evidence: an fMRI study of Broca’s area in lexical semantics. Neuropsychologia. In press.

    Google Scholar 

  122. Price CJ, Moore CJ, Humphreys GW, Wise RJS. Segregating semantic from phonological processes during reading. J Cogn Neurosci. 1997;9:727-733.

    Google Scholar 

  123. Mummery CJ, Patterson K, Hodges JR, Price CJ. Functional neuroanatomy of the semantic system: divisible by what? J Cogn Neurosci. 1998;10:766-777.

    PubMed  CAS  Google Scholar 

  124. Chee MWL, O’Craven KM, Bergida R, Rosen BR, Savoy RL. Auditory and visual word processing studied with fMRI. Hum Brain Mapp. 1999;7:15-28

    PubMed  CAS  Google Scholar 

  125. Roskies AL, Fiez JA, Balota DA, Raichle ME, Petersen SE. Task-dependent modulation of regions in the left inferior frontal cortex during semantic processing. J Cogn Neurosci. 2001;13:829-843.

    PubMed  CAS  Google Scholar 

  126. Bavelier D, Corina D, Jezzard P, Padmanabhan S, Clark VP, Karni A, et al. Sentence reading: a functional MRI study at 4 tesla. J Cogn Neurosci. 1997;9:664-686.

    Google Scholar 

  127. Herbster AN, Mintun MA, Nebes RD, Becker JT. Regional cerebral blood flow during word and nonword reading. Hum Brain Mapp. 1997;5:84-92.

    PubMed  CAS  Google Scholar 

  128. Indefrey P, Kleinschmidt A, Merboldt K-D, Krüger G, Brown C, Hagoort P, et al. Equivalent responses to lexical and nonlexical visual stimuli in occipital cortex: a functional magnetic resonance imaging study. Neuroimage. 1997;5:78-81.

    PubMed  CAS  Google Scholar 

  129. Chee MW, Caplan D, Soon CS, Sriram N, Tan EWL, Thiel T, et al. Processing of visually presented sentences in Mandarin and English studied with fMRI. Neuron. 1999;23:127-137.

    PubMed  CAS  Google Scholar 

  130. Pugh KR, Shaywitz BA, Shaywitz SE, Constable RT, Skudlarski P, Fulbright RK, et al. Cerebral organization of component processes in reading. Brain. 1996;119:1221-1238.

    PubMed  Google Scholar 

  131. Springer JA, Binder JR, Hammeke TA, Swanson SJ, Frost JA, Bellgowan PSF, et al. Language dominance in neurologically normal and epilepsy subjects: a functional MRI study. Brain. 1999;122:2033-2045.

    PubMed  Google Scholar 

  132. Pujol J, Deus J, Losilla JM, Capdevila A. Cerebral lateralization of language in normal left-handed people studied by functional MRI. Neurology. 1999;52:1038-1043.

    PubMed  CAS  Google Scholar 

  133. Vikingstad EM, George KP, Johnson AF, Cao Y. Cortical language lateralization in right handed normal subjects using functional magnetic resonance imaging. J Neurol Sci. 2000;175:17-27.

    PubMed  CAS  Google Scholar 

  134. Szaflarski JP, Binder JR, Possing ET, McKiernan KA, Ward DB, Hammeke TA. Language lateralization in left-handed and ambidextrous people: fMRI data. Neurology. 2002;59:238-244.

    PubMed  CAS  Google Scholar 

  135. Hund-Georgiadis M, Lex U, Friederici AD, von Cramon DY. Non-invasive regime for language lateralization in right- and left-handers by means of functional MRI and dichotic listening. Exp Brain Res. 2002; 145:166-176.

    PubMed  Google Scholar 

  136. Knecht S, Deppe M, Dräger B, Bobe L, Lohmann H, Ringelstein EB, et al.Language lateralization in healthy right-handers. Brain.2000;123:74-81.

    PubMed  Google Scholar 

  137. Shaywitz BA, Shaywitz SE, Pugh KR, Constable RT, Skudlarski P, Fulbright RK, et al. Sex differences in the functional organization of the brain for language. Nature. 1995;373:607-609.

    PubMed  CAS  Google Scholar 

  138. Price CJ, Moore CJ, Friston KJ. Getting sex into perspective. Neuroimage. 1996;3:S586.

    Google Scholar 

  139. Frost JA, Binder JR, Springer JA, Hammeke TA, Bellgowan PSF, Rao SM, et al. Language processing is strongly left lateralized in both sexes: Evidence from FMRI. Brain. 1999;122:199-208.

    PubMed  Google Scholar 

  140. Knecht S, Dräger B, Deppe M, Bobe L, Lohmann H, Flöel A, et al. Hand-edness and hemispheric language dominance in healthy humans. Brain. 2000;123:2512-2518.

    PubMed  Google Scholar 

  141. Rasmussen T, Milner B. The role of early left-brain injury in determining lateralization of cerebral speech functions. Ann N Y Acad Sci. 1977;299: 355-369.

    PubMed  CAS  Google Scholar 

  142. Loring DW, Meador KJ, Lee GP, Murro AM, Smith JR, Flanigin HF, et al. Cerebral language lateralization: Evidence from intracarotid amobarbital testing. Neuropsychologia. 1990;28:831-838.

    PubMed  CAS  Google Scholar 

  143. Grady CL, Maisog JM, Horwitz B, et al. Age-related changes in cortical blood flow activation during visual processing of faces and location. J Neurosci. 1994;14:1450-1462.

    PubMed  CAS  Google Scholar 

  144. Grady CL, McIntosh AR, Bookstein F, Horwitz B, Rapoport SI, Haxby JV. Age-related changes in regional cerebral blood flow during working memory for faces. Neuroimage. 1998;8:409-425.

    PubMed  CAS  Google Scholar 

  145. Woods RP, Dodrill CB, Ojemann GA. Brain injury, handedness, and speech lateralization in a series of amobarbital studies. Ann Neurol. 1988;23:510-518.

    PubMed  CAS  Google Scholar 

  146. Risse GL, Gates JR, Fangman MC. A reconsideration of bilateral language representation based on the intracarotid amobarbital procedure. Brain Lang. 1997;33:118-132.

    CAS  Google Scholar 

  147. Binder JR, Rao SM, Hammeke TA, Frost JA, Bandettini PA, Jesmanowicz A, et al. Lateralized human brain language systems demonstrated by task subtraction functional magnetic resonance imaging. Arch Neurol. 1995; 52:593-601.

    PubMed  CAS  Google Scholar 

  148. Cohen MS, Dubois RM. Stability, repeatability, and the expression of signal magnitude in functional magnetic resonance imaging. J Magn Reson Imaging. 1999;10:33-40.

    PubMed  CAS  Google Scholar 

  149. Binder JR, Hammeke TA, Possing ET, Swanson SJ, Spanaki MV, Morris GL, et al. Reliability and validity of language dominance assessment with functional MRI. Neurology. 2001;56 (Suppl 3):A158.

    Google Scholar 

  150. Xiong J, Rao S, Gao JH, Woldorff M, Fox PT. Evaluation of hemispheric dominance for language using functional MRI: a comparison with positron emission tomography. Hum Brain Mapp. 1998;6:42-58.

    PubMed  CAS  Google Scholar 

  151. Altenmüller DM, Kriechbaum W, Helber U, Moini S, Dichgans J, Petersen D. Cortical DC-potentials in identification of the language dominant hemisphere: linguistical and clinical aspects. Acta Neurochir (Wien).1993;56 (Suppl.):20-33.

    Google Scholar 

  152. Khedr EM, Hamed E, Said A, Basahi J. Handedness and language cerebral lateralization. Eur J Appl Physiol. 2002;87:469-473.

    PubMed  Google Scholar 

  153. Deppe M, Knecht S, Papke K, Lohmann H, Fleischer H, Heindel W, et al. Assessment of hemispheric language lateralization: A comparison between fMRI and fTCD. J Cereb Blood Flow Metab. 2000;20:263-268.

    PubMed  CAS  Google Scholar 

  154. Foundas AL, Leonard CM, Gilmore R, Fennell E, Heilman KM. Planum temporale asymmetry and language dominance. Neuropsychologia. 1994;32:1225-1231.

    PubMed  CAS  Google Scholar 

  155. Chelune GJ. Using neuropsychological data to forecast postsurgical cognitive outcome. In: Lüders H, editor. Epilepsy Surgery. New York: Raven Press; 1991:477-485.

    Google Scholar 

  156. Schwartz TH, Devinsky O, Doyle W, Perrine K. Preoperative predictors of anterior temporal language areas. J Neurosurg. 1998;89:962-970.

    PubMed  CAS  Google Scholar 

  157. Hermann BP, Perrine K, Chelune GJ, Barr W, Loring DW, Strauss E, et al. Visual confrontation naming following left anterior temporal lobectomy: A comparison of surgical approaches. Neuropsychology. 1999; 13:3-9.

    PubMed  CAS  Google Scholar 

  158. Grabowski TJ, Damasio H, Tranel D, Ponto LL, Hichwa RD, Damasio AR. A role for left temporal pole in the retrieval of words for unique entities. Hum Brain Mapp. 2001;13:199-212.

    PubMed  CAS  Google Scholar 

  159. Hamberger MJ, Goodman RR, Perrine K, Tamny TR. Anatomic dissociation of auditory and visual naming in the lateral temporal cortex. Neurology. 2001;56:56-61.

    PubMed  CAS  Google Scholar 

  160. Hermann BP, Wyler AR, Somes G, Clement L. Dysnomia after left anterior temporal lobectomy without functional mapping: frequency and correlates. Neurosurgery. 1994;35:52-57.

    PubMed  CAS  Google Scholar 

  161. Langfit JT, Rausch R. Word-finding deficits persist after left anterotemporal lobectomy. Arch Neurol. 1996;53:72-76.

    Google Scholar 

  162. Davies KG, Bell BD, Bush AJ, Hermann BP, Dohan FC, Jaap AS. Naming decline after left anterior temporal lobectomy correlates with pathological status of resected hippocampus. Epilepsia. 1998;39:407-419.

    PubMed  CAS  Google Scholar 

  163. Bell BD, Davies KG, Hermann BP, Walters G. Confrontation naming after anterior temporal lobectomy is related to age of acquisition of the object names. Neuropsychologia. 2000;38:83-92.

    PubMed  CAS  Google Scholar 

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Binder, J.R. (2006). fMRI of Language Systems: Methods and Applications. In: Faro, S.H., Mohamed, F.B. (eds) Functional MRI. Springer, New York, NY. https://doi.org/10.1007/0-387-34665-1_10

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