Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
7. References
P.L. Yeagle, Modulation of membrane function by cholesterol. Biochimie 73(10), 1303–13110 (1991).
L.J. Pike, Lipid rafts: bringing order to chaos. J Lipid Res 44(4), 655–667 (2003).
D.A. Brown and E. London, Structure and function of sphingolipid-and cholesterolrich membrane rafts. J Biol Chem 275(23), 17221–17224 (2000).
T. Harder, Lipid raft domains and protein networks in T-cell receptor signal transduction. Curr Opin Immunol 16(3), 353–359 (2004).
H.T. He, A. Lellouch, and D. Marguet, Lipid rafts and the initiation of T cell receptor signaling. Sem Immunol 17(1), 23–33 (2005).
H.A. Lucero and P.W. Robbins, Lipid rafts-protein association and the regulation of protein activity. Arch Biochem Biophys 426(2), 208–224 (2004).
A.K. Rouquette-Jazdanian, C. Pelassy, J.P. Breitmayer and C. Aussel, Revaluation of the role of cholesterol in stabilizing rafts implicated in T cell receptor signaling. Cell Signal 18(1),105–122 (2006).
T. Fulop, A. Larbi, A. Wikby, E. Mocchegiani, K. Hirokawa and G, Pawelec, Dysregulation of T-cell function in the elderly: scientific basis and clinical implications. Drugs Aging 22(7), 589–603 (2005).
K.G. Harikumar, V. Puri, R. Singh, K. Hanada, R.E. Pagano and L.J. Miller, Differential effects of modification of membrane cholesterol and sphingolipids on the conformation, function, and trafficking of the G protein-coupled cholecystokinin receptor. J Biol Chem 280(3), 2176–2185 (2005).
Y.K. Ho, M.S. Brown, D.W. Bilheimer and J.L. Goldstein, Regulation of low density lipoprotein receptor activity in freshly isolated human lymphocytes. J Clin Invest 58(6), 1465–1474 (1976).
F.R. Verhoeye, O. Descamps, B. Husson, J.C. Hodekijn, M.F. Ronveaux-Dupal, J.F. Lontie and F.R. Heller, An improved method for detection of low density lipoprotein receptor defects in human T lymphocytes. J Lipid Res 37(6), 1377–1384 (1996).
J.G. LeHoux, N. Kandalaft, S. Belisle and D. Belabarba, Characterization of 3-hydroxy-3-methylglutaryl coenzyme A reductase in human adrenal cortex. Endocrinology 117(4), 1462–1468 (1985).
M.S. Brown and J.L. Godstein, Receptor-mediated control of cholesterol metabolism. Science 191(4223), 150–154 (1976).
L.O. Martinez, S. Jacquet, F. Tercé F, X. Collet, B. Perret and R. Barbaras, New insight on the molecular mechanisms of high-density lipoprotein cellular interactions. Cell Mol Life Sci 61(18), 2343–2360 (2004).
A. von Eckardstein, M. Hersberger and L. Rohrer, Current understanding of the metabolism and biological actions of HDL. Curr Opin Clin Nutr Metab Care 8(2), 147–152 (2005).
A. Monjas, A. Alcover and B. Alarcon, Engaged and bystander T cell receptors are down-modulated by different endocytotic pathways. J Biol Chem 279(53), 55367–55384 (2004).
E.P. Kilsdonk, P.G. Yancey, G.W. Stoudt, F.W. Bangerter, W.J. Johnson, M.C. Phillips and G.A. Rothblat, Cellular cholesterol efflux mediated by cyclodextrins. J. Biol Chem 270(29), 17250–17256 (1995).
A. Larbi, N. Douziech, A. Khalil, G. Dupuis, S. Gheraïri, P. Guérard and T. Fülöp, Effects of Methyl-β-cyclodextrin on T lymphocytes lipid rafts with aging. Exp. Gerontol 39(4), 551–558 (2004).
V. Horejsi, Transmembrane adaptor proteins in membrane microdomains: important regulators of immunoreceptor signaling. Immunol Lett 92(1–2), 43–49 (2004).
P.S. Kabouridis, J. Janzen, A.L. Magee and S.C. Ley, Cholesterol depletion disrupts lipid rafts and modulates the activity of multiple signalling pathways in T lymphocytes. Eur J Immunol 30(3), 954–963 (2000).
S. Tani-Ichi, K. Maruyama, N. Kondo, M. Nagafuko, K. Kabayama, J. Inokuchi, Y. Shimada, Y. Ohno-Iwashita, H. Yagita, S. Kawano and A. Kosugi, Structure and function of lipid rafts in human activated T cells. Int Immunol 17(6), 749–758 (2005).
P. Pizzo, E. Giurisato, A. Bigsten, M. Tassi, R. Tavano, A. Shaw and A. Viola, Physiological T cell activation starts and propagates in lipid rafts. Immunol Lett 91(1), 3–9 (2004).
A. Larbi, N. Douziech, G. Dupuis, A. Khalil, H. Pelletier, K.P. Guerard and T. Fulop, Age-associated alterations in the recruitment of signal-transduction proteins to lipid rafts in human T lymphocytes. J Leukoc Biol 75(2), 373–381 (2004).
T. Fülöp, N. Douziech, A.C. Goulet, S. Desgeorges, A. Linteau, G. Lacombe and G. Dupuis, Cyclodextrin modulation of T lymphocyte signal transduction with aging. Mech Age Dev 122(13), 1413–1431 (2001).
K. Gaus, J.J. Gooding, R.T. Dean, L. Kitharides and W. Jessup, A kinetic model to evaluate cholesterol efflux from THP-1 macrophages to apolipoprotein A-1. Biochemistry 40(31), 9363–9373 (2001)
D.H. Nguyen, J.C. Espinoza and D.D. Taub, Celular cholesterol enrichment impairs T cell activation and chemotaxis. Mech Age Dev 125(9), 641–650 (2004).
W.G. Wood, F. Schroeder, U. Igbavboa, N.A. Avdulov and S.V. Chochina, Brain membrane cholesterol domains, aging and amyloid beta-peptides. Neurobiol Aging 23(5), 685–694 (2002).
A, Subtil, I. Gaidarov, K. Kobylarz, M.A. Lampson, J.H. Ken and T.E. McGraw, Acute cholesterol depletion inhibits clathrin-coated pit budding. Proc Natl Acad Sci. USA 96(12), 6775–6780 (1999).
A. Bellacosa, C.C. Kumar, A. Di Critofano and J.R. Testa, Activation of AKT kinases in cancer: implications for therapeutic targeting. Adv Cancer Res 94, 29–86 (2005).
T.M. Razzaq, P. Ozegbe, E.C. Jury, P. Sembi, N.M. Blackwell and P.S. Kabouridis, Regulation of T-cell receptor signalling by membrane microdomains. Immunology 113(4), 413–426 (2004).
M.M. Zatz and A.L. Goldstein, Thymosins, lymphokines, and the immunology of aging. Gerontology 31(4), 263–269 (1985).
M.P. Chang, T. Makinodan, W.J. Peterson and B.L. Strehler, Role of T cells and adherent cells in age-related decline in murine interleukin 2 production. J Immunol 129(6), 2426–2434 (1983).
N. Douziech, I. Seres, A. Larbi, E. Szikszay, P.M. Roy, M. Arcand, G. Dupuis and T. Fülöp, Modulation of human lymphocyte proliferative response with aging. Exp. Gerontol 37(2–3), 369–387 (2002).
A.A. Sadighi-Akha and R.A. Miller, Signal transduction in the aging immune system. Curr Opin Immunol 17(5), 486–491 (2005).
G. Pawelec, K. Hirokawa and T. Fülöp, Altered T cell signaling with aging. Mech. Age Dev 122(14), 1623–1637 (2001).
L. Zhuang, J. Kim, R.M. Adam, K.R. Solomon and M.R. Freeman, Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts. J Clin Invest 115(4), 959–968 (2005).
F. Mach, Satatins as Immunomodulatory agents. Circulation 109(21 Suppl 1), II15–117 (2004).
J.C. Plana and P.H. Jones, The use of statins in acute coronary syndromes: the mechanisms behind the outcomes. Curr Atheroscler Rep 3(5), 355–364 (2001).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Springer Science+Business Media, LLC
About this paper
Cite this paper
Fulop, T., Dupuis, G., Fortin, C., Douziech, N., Larbi, A. (2006). T Cell Response in Aging: Influence of Cellular Cholesterol Modulation. In: Tsoukas, C. (eds) Lymphocyte Signal Transduction. Advances in Experimental Medicine and Biology, vol 584. Springer, Boston, MA. https://doi.org/10.1007/0-387-34132-3_12
Download citation
DOI: https://doi.org/10.1007/0-387-34132-3_12
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-31335-1
Online ISBN: 978-0-387-34132-3
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)