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Hypoacetylaspartia: Clinical and Biochemical Follow-Up of a Patient

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N-Acetylaspartate

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5. References

  1. E. Martin, A. Capone, J. Schneider, J. Hennig, and T. Thiel, Absence of N-acetylaspartate in the human brain: impact on neurospectroscopy?, Ann. Neurol. 49, 518–521 (2001).

    Article  PubMed  CAS  Google Scholar 

  2. E.V. Sullivan, E. Adalsteinsson, D.M. Spielman, R.E. Hurd, and A. Pfefferbaum, N-acetylaspartate — A marker of neuronal integrity, Ann. Neurol. 50, 823 (2001).

    Article  PubMed  CAS  Google Scholar 

  3. D.L. Arnold, N. de Stefano, P.M. Matthews, and B. Trapp, N-acetylaspartate: usefulness as an indicator of viable neuronal tissue, Ann. Neurol. 50, 823 (2001).

    Article  PubMed  CAS  Google Scholar 

  4. E. Boltshauser, B. Schmitt, R.A. Wevers, U. Engelke, A.B. Burlina and A.P. Burlina, Follow-up of a child with hypoacetylaspartia, Neuropediatrics 35, 255–258 (2004).

    Article  PubMed  CAS  Google Scholar 

  5. U.F.H. Engelke, M.L.F. Liebrand-Van Sambeek, J.G.N. De Jong, J.G. Leroy, E. Morava, J.A.M. Smeitink and R.A. Wevers, N-acetylated metabolites in urine: proton nuclear magnetic resonance spectroscopic study on patients with inborn errors of metabolism, Clin. Chem. 50, 58–66 (2004).

    Article  PubMed  CAS  Google Scholar 

  6. A.P. Burlina, V. Ferrari, P. Divry, W. Gradowska, C. Jakobs, M.J. Bennett, A.C. Sewell, C. Dionisi-Vici, and A.B. Burlina, N-acetylaspartylglutamate in Canavan disease: an adverse effector?, Eur. J. Pediatr. 158, 406–409 (1999).

    Article  PubMed  CAS  Google Scholar 

  7. K.F. Faull, R. Rafie, N. Pascoe, L. Marsh, and A. Pfefferbaum, N-acetyl aspartic acid (NAA) and N-acetyl aspartylglutamic acid (NAAG) in human ventricular, subarachnoid, and lumbar cerebrospinal fluid, Neurochem. Res. 24, 1249–1261 (1999).

    Article  PubMed  CAS  Google Scholar 

  8. V. Brovia, A. Ricciardi, and L. Barbeito, N-acetyl-aspartylglutamate (NAAG) in human cerebrospinal fluid: determination by high performance liquid chromatography, and influence of biological variables, Amino Acids 9, 175–184 (1995).

    CAS  Google Scholar 

  9. L.M. Gehl, O.H. Saab, T. Bzdega, B. Wroblewska, and J.H. Neale, Biosynthesis of NAAG by an enzyme-mediated process in rat central nervous system neurons and glia, J. Neurochem. 90, 989–997 (2004).

    Article  PubMed  CAS  Google Scholar 

  10. A.P. Burlina, V. Ferrari, L. Bonafé, and A.B. Burlina, Clinical and biochemical follow-up of a patient with Canavan disease, J. Inherit. Metab. Dis. 21(suppl. 2), 48 (1998).

    Google Scholar 

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Burlina, A.P., Schmitt, B., Engelke, U., Wevers, R.A., Burlina, A.B., Boltshauser, E. (2006). Hypoacetylaspartia: Clinical and Biochemical Follow-Up of a Patient. In: Moffett, J.R., Tieman, S.B., Weinberger, D.R., Coyle, J.T., Namboodiri, A.M.A. (eds) N-Acetylaspartate. Advances in Experimental Medicine and Biology, vol 576. Springer, Boston, MA . https://doi.org/10.1007/0-387-30172-0_20

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