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Neuroprotection by cAMP

Another Brick in the Wall

  • Chapter
Brain Repair

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 557))

Abstract

Programmed cell death occurs in the nervous system both in normal development as well as in pathologic conditions, and is a key issue related to both brain repair and neurodegenerative diseases. Modulation of cell death in the nervous system may involve neurotrophic factors and other peptides, neurotransmitters and neuromodulators, that activate various signal transduction pathways, which in turn interact with the cell death execution machinery. Here we discuss the role of the second messenger cyclic adenosine 3′5′-monophosphate (cAMP) in cell death, and summarize current evidence that cAMP is a nodal point of neuroprotective signaling pathways.

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Authors and Affiliations

  1. Laboratório de Neurogênese, Instituto de Biofísica da UFRJ, Rio de Janeiro, Brazil

    Mariana S. Silveira

  2. Instituto de Biofísica da UFRJ CCS, Cidade Universitária, Rio de Janeiro, Brazil

    Rafael Linden

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  1. Mariana S. Silveira
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  2. Rafael Linden
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  1. Department of Neurology, University of Göttingen, Göttingen, Germany

    Mathias Bähr

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Silveira, M.S., Linden, R. (2006). Neuroprotection by cAMP. In: Bähr, M. (eds) Brain Repair. Advances in Experimental Medicine and Biology, vol 557. Springer, Boston, MA. https://doi.org/10.1007/0-387-30128-3_10

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