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Uterine Sarcomas

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Gynecologic Cancer

Part of the book series: M. D. Anderson Cancer Care Series ((MDCCS,volume 5))

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Suggested Readings

  • Arrastea CD, Fruchter RG, Clark M, et al. Uterine carcinosarcomas: incidence and trends in management and survival. Gynecol Oncol 1997;65:158–163.

    Google Scholar 

  • Berchuck A, Rubin SC, Hoskins WJ, et al. Treatment of uterine leiomyosarcoma. Obstet Gynecol 1988;71:845–850.

    CAS  PubMed  Google Scholar 

  • Berchuck A, Rubin SC, Hoskins WJ, et al. Treatment of endometrial stromal tumors. Gynecol Oncol 1990;36:60–65.

    Article  CAS  PubMed  Google Scholar 

  • Bitterman P, Chun B, Kurman RJ. The significance of epithelial differentiation in mixed mesodermal tumors of the uterus. Am J Surg Pathol 1990;14:317–328.

    CAS  PubMed  Google Scholar 

  • Callister M, Ramondetta LM, Jhingran A, et al. Malignant mixed mullerian tumors of the uterus: analysis of patterns of failure, prognostic factors, and treatment outcome. Int J Radiat Oncol Biol Phys 2004;58:786–796.

    Article  PubMed  Google Scholar 

  • Curtin JP, McGuire WP, Brooker D. Evaluation of paclitaxel in the treatment of persistent or recurrent mixed mesodermal tumors of the uterus. GOG Statistical Report, 1998. GOG protocol #130B (July).

    Google Scholar 

  • Dinh TA, Oliva EA, Fuller AF Jr., et al. The treatment of uterine leiomyosarcoma. Results from a 10-year experience (1990–1999) at the Massachusetts General Hospital. Gynecol Oncol 2004;92:648–652.

    Article  PubMed  Google Scholar 

  • DiSaia PJ, Castro JR, Rutledge FN. Mixed mesodermal sarcoma of uterus. Am J Roentgenol Radium Ther Nucl Med 1973;117:632–636.

    CAS  PubMed  Google Scholar 

  • Echt G, Jepson J, Steel J, et al. Treatment of uterine sarcomas. Cancer 1990;66:35–39.

    CAS  PubMed  Google Scholar 

  • Eltabbakh GH, Yadav R. Good response of malignant mixed mullerian tumor of the ovary to paclitaxel and cisplatin chemotherapy. Eur J Gynaecol Oncol 1999;20:355–356.

    CAS  PubMed  Google Scholar 

  • Ferrer F, Sabater S, Farrus B, et al. Impact of radiotherapy on local control and survival in uterine sarcomas: a retrospective study from the Group Oncologic Catala-Occita. Int J Radiat Oncol Biol Phys 1999;44:47–52.

    Article  CAS  PubMed  Google Scholar 

  • Fotiou S, Hatjieleftheriou G, Kyrousis G, et al. Long term tamoxifen treatment: a possible aetiological factor in the development of uterine carcinosarcoma: two case reports and review of the literature. Anticancer Res 2000;20:2015–2020.

    CAS  PubMed  Google Scholar 

  • Gershenson DM, Kavanagh JJ, Copeland LJ, et al. Cisplatin therapy for disseminated mixed mesodermal sarcoma of the uterus. J Clin Oncol 1987;5:618–621.

    CAS  PubMed  Google Scholar 

  • Hannigan EV, Freedman RS, Elder KW, et al. Treatment of advanced uterine sarcoma with adriamycin. Gynecol Oncol 1983;16:101–104.

    CAS  PubMed  Google Scholar 

  • Harlow BL, Weiss NS, Lofton S. The epidemiology of sarcomas of the uterus. J Natl Cancer Inst 1986;76:399–402.

    CAS  PubMed  Google Scholar 

  • Hoffmann W, Schmandt S, Kortmann RD, et al. Radiotherapy in the treatment of uterine sarcomas: a retrospective analysis of 54 cases. Gynecol Obstet Invest 1996;19:49–57.

    Google Scholar 

  • Hornback NB, Omura G, Major FJ. Observations on the use of adjuvant radiation therapy in patients with stage I and II uterine sarcoma. Int J Radiat Oncol Biol Phys 1986;12:2127–2130.

    CAS  PubMed  Google Scholar 

  • Knocke TH, Kurcera H, Dörfler D, et al. Results of postoperative radiotherapy in the treatment of sarcoma of the corpus uteri. Cancer 1998;83:1972–1979.

    Article  CAS  PubMed  Google Scholar 

  • Kushner DM, Webster KD, Belinson JL, et al. Safety and efficacy of adjuvant single-agent ifosfamide in uterine sarcomas. Gynecol Oncol 2000;78:221–227.

    Article  CAS  PubMed  Google Scholar 

  • Leunen M, Breugelmans M, DeSutter P, et al. Low-grade endometrial stromal sarcoma treated with the aromatase inhibitor letrozole. Gynecol Oncol 2004;95:769–771.

    Article  CAS  PubMed  Google Scholar 

  • Levenback C, Rubin SC, McCormack PM, et al. Resection of pulmonary metastases from uterine sarcomas. Gynecol Oncol 1992;45:202–205.

    Article  CAS  PubMed  Google Scholar 

  • Levenback CF, Tortolero-Luna G, Pandey DK, et al. Uterine sarcoma. Obstet Gynecol Clin North Am 1996;23:457–473.

    CAS  PubMed  Google Scholar 

  • Look KY, Sandler A, Blessing JA, et al. Phase II trial of gemcitabine as second-line chemotherapy of uterine leiomyosarcoma: a Gynecologic Oncology Group (GOG) study. Gynecol Oncol 2004;92:644–647.

    CAS  PubMed  Google Scholar 

  • Major FJ, Blessing JA, Silverberg SG, et al. Prognostic factors in early-stage uterine sarcoma: a Gynecologic Oncology Group study. Cancer 1993;71:1702–1709.

    CAS  PubMed  Google Scholar 

  • Manolitsas TP, Wain GV, Williams KE, et al. Multimodality therapy for patients with clinical stage I and II malignant mixed müllerian tumors of the uterus. Cancer 2001;91:1937–1943.

    Article  Google Scholar 

  • Markman M, Kennedy A, Webster K, et al. Persistent chemosensitivity to platinum and/or paclitaxel in metastatic endometrial cancer. Gynecol Oncol 1999;73:422–423.

    CAS  PubMed  Google Scholar 

  • Muss HB, Bundy B, DiSaia PJ, et al. Treatment of recurrent or advanced uterine sarcoma. A randomized trial of doxorubicin versus doxorubicin and cyclophosphamide (a phase III trial of the Gynecologic Oncology Group). Cancer 1985;55:1648–1653.

    CAS  PubMed  Google Scholar 

  • Nasu K, Kawano Y, Hirota Y, et al. Immunohistochemical study of c-erb B-2 expression on MMMT of the female genital tract. J Obstet Gynaecol Res 1996;22:347–351.

    CAS  PubMed  Google Scholar 

  • Omura GA, Blessing JA, Major F, et al. A randomized clinical trial of adjuvant adriamycin in uterine sarcomas: a Gynecologic Oncology Group Study. J Clin Oncol 1985;3:1240–1245.

    CAS  PubMed  Google Scholar 

  • Omura GA, Major FJ, Blessing JA, et al. A randomized study of adriamycin with and without dimethyl triazenoimidazole carboxamide in advanced uterine sarcomas. Cancer 1983;52:626–632.

    CAS  PubMed  Google Scholar 

  • Ramondetta LM, Burke TW, Levenback C, et al. Treatment of uterine papillary serous carcinoma with paclitaxel. Gynecol Oncol 2001;82:156–161.

    Article  CAS  PubMed  Google Scholar 

  • Resnick E, Chambers SK, Carcangiu ML, et al. A phase II study of etoposide, cisplatin, and doxorubicin chemotherapy in mixed mullerian tumors (MMT) of the uterus. Gynecol Oncol 1995;56:370–375.

    Google Scholar 

  • Rose PG, Boutselis JG, Sachs L. Adjuvant therapy for stage I uterine sarcoma. Am J Obstet Gynecol 1987;156:660–662.

    CAS  PubMed  Google Scholar 

  • Schwartz SM, Weiss NL, Saling JR, et al. Exogenous sex hormone use, correlates of endogenous hormone levels and the incidence of histologic types of sarcoma of the uterus. Cancer 1996;4:717–724.

    Google Scholar 

  • Silverberg SG, Major FJ, Blessing JA, et al. Carcinosarcoma (malignant mixed mesodermal tumor) of the uterus: a GOG pathologic study. Int J Gynecol Pathol 1990;9:1–19.

    CAS  PubMed  Google Scholar 

  • Sit AS, Price FV, Kelley JL, et al. Chemotherapy for malignant mixed mullerian tumors of the ovary. Gynecol Oncol 2000;79:196–200.

    Article  CAS  PubMed  Google Scholar 

  • Spanos WJ, Peters LJ, Oswald MJ. Patterns of recurrence in malignant mixed mullerian tumor of the uterus. Cancer 1986;57:155–159.

    PubMed  Google Scholar 

  • Sutton G, Blessing J, Hanjana P, et al. Phase II evaluation of liposomal doxorubicin (Doxil) in recurrent or advanced leiomyosarcoma of the uterus: a Gynecologic Oncology Group study. Gynecol Oncol 2005;96:749–752.

    CAS  PubMed  Google Scholar 

  • Sutton G, Blessing JA, Park R, et al. Ifosfamide treatment of recurrent or metastatic endometrial stromal sarcomas previously unexposed to chemotherapy: a study of the Gynecologic Oncology Group. Obstet Gynecol 1996a;87:747–750.

    Article  CAS  PubMed  Google Scholar 

  • Sutton GP, Ashbury R, Silverberg S. Adjuvant ifosfamide, mesna, and cisplatin in patients with completely resected stage I or II carcinosarcoma of the uterus: a study of the Gynecologic Oncology Group. Proceedings of the American Society of Clinical Oncology 1997;15:A1288.

    Google Scholar 

  • Sutton GP, Blessing JA, Barnhill DL. Phase II trial of ifosfamide and mesna in patients with recurrent or advanced endometrial stromal sarcoma of the uterus—preliminary report [abstract]. Proceedings of the American Society of Clinical Oncology 1991.

    Google Scholar 

  • Sutton GP, Blessing JA, Barrett RJ, et al. Phase II trial of ifosfamide and mesna in leiomyosarcoma of the uterus: a Gynecologic Oncology Group study. Am J Obstet Gynecol 1992;166:556–559.

    CAS  PubMed  Google Scholar 

  • Sutton GP, Blessing JA, Malfetano JH. Ifosfamide and doxorubicin in the treatment of advanced leiomyosarcomas of the uterus: a Gynecologic Oncology Group Study. Gynecol Oncol 1996b;62:226–229.

    Article  CAS  PubMed  Google Scholar 

  • Sutton GP, Blessing JA, Rosenshein N, Photopulos G, DiSaia PJ. Phase II trial of ifosfamide and mesna in mixed mesodermal tumors of the uterus (a Gynecologic Oncology Group study). Am J Obstet Gynecol 1989;191:309–312.

    Google Scholar 

  • Sutton GP, Williams SD, Hsiu JG. Ifosfamide and the uroprotector mesna with or without cisplatin in patients with advanced, persistent or recurrent mixed mesodermal tumors of the uterus [abstract]. Proceedings of the Society of Gynecologic Oncologists 1998.

    Google Scholar 

  • Swisher EM, Gown AM, Skelly M, et al. The expression of epidermal growth factor receptor, Her-2/Neu, p53, and Ki-67 antigen in uterine malignant mixed mesodermal tumors and adenosarcoma. Gynecol Oncol 1996;60:81–88.

    Article  CAS  PubMed  Google Scholar 

  • Szlosarek PW, Lofts FJ, Pettengell R, et al. Effective treatment of a patient with a high-grade endometrial stromal sarcoma with an accelerated regimen of carboplatin and paclitaxel. Anticancer Drugs 2000;11:275–278.

    Article  CAS  PubMed  Google Scholar 

  • Thigpen JT, Blessing JA, Beecham J, et al. Phase II trial of cisplatin as first line chemotherapy in patients with advanced or recurrent uterine sarcomas: a Gynecologic Oncology Group study. J Clin Oncol 1991;9:1962–1966.

    CAS  PubMed  Google Scholar 

  • Thigpen JT, Blessing JA, Orr JW, et al. Phase II trial of cisplatin in the treatment of patients with advanced or recurrent mixed mesodermal sarcomas of the uterus: a Gynecologic Oncology Group study. Cancer Treatment Reports 1986;70:271–274.

    CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Gynecologic Oncology, USA

    Lois M. Ramondetta MD (Associate Professor) & Diane C. Bodurka MD (Associate Professor)

  2. Department of Pathology, USA

    Michael T. Deavers MD (Associate Professor)

  3. Department of Radiation Oncology, USA

    Anuja Jhingran MD (Associate Professor)

Authors
  1. Lois M. Ramondetta MD
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  2. Diane C. Bodurka MD
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  3. Michael T. Deavers MD
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  4. Anuja Jhingran MD
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Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1202, Houston, TX, 77030-4009, USA

    Patricia J. Eifel MD

  2. Department of Gynecologic Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1362, Houston, TX, 77030-4009, USA

    David M. Gershenson MD

  3. Department of Gynecologic Medical Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1364, Houston, TX, 77030-4009, USA

    John J. Kavanagh MD

  4. Department of Pathology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 85, Houston, TX, 77030-4009, USA

    Elvio G. Silva MD

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Ramondetta, L.M., Bodurka, D.C., Deavers, M.T., Jhingran, A. (2006). Uterine Sarcomas. In: Eifel, P.J., Gershenson, D.M., Kavanagh, J.J., Silva, E.G. (eds) Gynecologic Cancer. M. D. Anderson Cancer Care Series, vol 5. Springer, New York, NY. https://doi.org/10.1007/0-387-28796-5_9

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  • DOI: https://doi.org/10.1007/0-387-28796-5_9

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-28794-2

  • Online ISBN: 978-0-387-28796-6

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