Abstract
Nuclear factor κB (NF-κB) is regarded as a key regulator of inflammation; hence, several inflammatory diseases result from deregulation of NF-κB signaling. There is, however, also increasing evidence for a preponderant role of NF-κB in tumor development and progression. Constitutive activation of NF-κB activity by signaling defects, mutations or chromosomal rearrangements can be found in a wide variety of cancers. Additionally, a causal link between inflammation and cancer has been noted, which makes NF-κB an interesting target for development of both anti-inflammatory and anti-cancer therapeutics. Here, we review current knowledge of NF-κB signal transduction, focusing on the regulation of its transcriptional activity by post-translational modification of the NF-κB subunits.
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Vermeulen, L., Vanden Berghe, W., Haegeman, G. (2006). Regulation if NF-κB Transcriptional Activity. In: Dalgleish, A.G., Haefner, B. (eds) The Link Between Inflammation and Cancer. Cancer Treatment and Research, vol 130. Springer, Boston, MA. https://doi.org/10.1007/0-387-26283-0_4
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DOI: https://doi.org/10.1007/0-387-26283-0_4
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