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Closing the Loop: Stimulation Feedback Systems for Embodied MEA Cultures

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Advances in Network Electrophysiology

9.7 Conclusion

By combining MEA electrophysiology with long-term time-lapse imaging, it is possible to make correlations between changes in network function and changes in neuronal morphology. By re-embodying dissociated cultured networks, network function can be mapped onto behavior, and in vitro research can now make use of a new kind of behavioral studies that include detailed (submicron) imaging not possible in vivo. By closing the sensory-motor loop around MEA cultures, they are more likely to shed light on the mechanisms of learning, memory, and information processing in animals.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Georgia Institute of Technology, Emory Univrsity School of Medicine, Atlanta, GA, USA

    Steve M. Potter

  2. Department of Physics, California Institute of Technology, Pasadena, CA

    Daniel A. Wagenaar

  3. Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA

    Thomas B. DeMarse

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  1. Steve M. Potter
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  1. Panasonic Research and Development, Company of America, Cypress, CA, 92630, USA

    Makoto Taketani

  2. Department of Biological Sciences, University of Southern California, Los Angeles, Los Angeles, CA, USA

    Michel Baudry

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Potter, S.M., Wagenaar, D.A., DeMarse, T.B. (2006). Closing the Loop: Stimulation Feedback Systems for Embodied MEA Cultures. In: Taketani, M., Baudry, M. (eds) Advances in Network Electrophysiology. Springer, Boston, MA . https://doi.org/10.1007/0-387-25858-2_9

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