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Age-Related Effects of Alcohol on Memory and Memory-Related Brain Function in Adolescents and Adults

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Recent Developments in Alcoholism

Part of the book series: Recent Developments in Alcoholism ((RDIA,volume 17))

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References

  • Acheson S, Stein R., Swartzwelder HS (1998) Impairment of semantic and figural memory by acute alcohol: Age-dependent effects. Alc Clin Exp Res 22:1437–1442.

    Google Scholar 

  • Aguayo L, Peoples R, Yeh H, Yevenes G (2002) GABAA receptors as molecular sites of alcohol action: Direct or indirect actions? Current Topics in Medicinal Chemistry 2:869–885.

    Article  PubMed  Google Scholar 

  • Becker HC, Hale RL (1993) Repeated episodes of alcohol withdrawal potentiate the severity of subsequent withdrawal seizures: An animal model of alcohol withdrawal "kindling." Alc Clin Exp Res 17:94–98.

    Article  Google Scholar 

  • Behringer K, Gault L, Siegel R (1996) Differential regulation of GABAA receptor subunit mRNAs in rat cerebellar granule neurons: Importance of environmental cues. J Neurochem 66:1347–1353.

    Article  PubMed  Google Scholar 

  • Best PJ, White AM. (1998) Hippocampal cellular activity: a brief history of space. Proc Natl Acad Sci 95:2717–2719.

    Article  PubMed  Google Scholar 

  • Bliss TVP, Collinridge GL (1993) A synaptic model of memory: Long-term potentiation in the hippocampus. Nature 361:31–39.

    Article  PubMed  Google Scholar 

  • Blitzer RD, Gil O, Landau EM (1990) Long-term potentiation in rat hippocampus is inhibited by low concentrations of ethanol. Brain Res 537:203–208.

    Article  PubMed  Google Scholar 

  • Bond NW (1979) Impairment of shuttlebox avoidance learning following repeated alcohol with-drawal episodes in rats. Pharmacol Biochem Behav 11:589–591.

    Article  PubMed  Google Scholar 

  • Bray RM (1996) Department of defense survey of health related behaviors among military personnel. The Research Triangle Institute, February.

    Google Scholar 

  • Brown AS, Tapert SF, Granholm E, Delis DC (2000) Neurocognitive functioning of adolescents: effects of protracted alcohol use. Alcohol Clin Exp Res 24:164–171.

    Article  PubMed  Google Scholar 

  • Brown M, Anton R, Malcolm R, Ballenger J (1988) Alcohol detoxification and withdrawal seizures: Clinical support for a kindling hypothesis. Biol Psychiat 23:507–514.

    Article  PubMed  Google Scholar 

  • Casey B (1999) Images in neuroscience. Brain development, XII: maturation in brain activation. Am J Psychiatry 156:504.

    PubMed  Google Scholar 

  • Cherubini E, Gaiarsa J, Ben-Ari Y (1991) GABA: An excitatory transmitter in early postnatal life. Trends Neurosci 14:515–519.

    Article  PubMed  Google Scholar 

  • Chin JH, Goldstein DB (1977) Effects of low concentrations of ethanol on the fluidity of spinlabeled erythrocyte and brain membranes. Molec Pharmacol 13:435–441.

    Google Scholar 

  • Chugani H (1998) Biological Basis of Emotions: Brain Systems and Brain Development. Pediatrics 102:1225–1229.

    Google Scholar 

  • Crews F, Chandler L (1993) Excitotoxicity and the neuropathology of alcohol. In: Alcohol Induced Brain Damage (W.A. Hunt and S.J. Nixon, Eds.). NIH Publication No. 93–3549: 355–371.

    Google Scholar 

  • Criswell HE, Simson PE, Duncan GE, McCown TJ, Herbert JS, Morrow AL, Breese GR (1993) Molecular basis for regionally specific action of ethanol on gamma-aminobutyric acidA receptors: Generalization to other ligand-gated ion channels. J Pharmacol Exp Ther 267:522–537.

    PubMed  Google Scholar 

  • De Bellis MD, Clark DB, Beers SR, Soloff PH, Boring AM, Hall J, Kersh A, Keshavan MS (2000) Hippocampal volume in adolescent-onset alcohol use disorders. Am J Psychiatry 157:737–744.

    Article  PubMed  Google Scholar 

  • Dolin SJ, Little HJ (1989) Are changes in neuronal calcium channels involved in ethanol tolerance?. J Pharmacol Exp Ther 250:985–91.

    PubMed  Google Scholar 

  • Fleming R (1935) A psychiatric concept of acute alcoholic intoxification. Am J Psychiatry 92:89–108.

    Google Scholar 

  • Giedd J, Blumenthal J, Jeffries N, Castllanos F, Liu H, Zijdenbos A, Paus T, Evans A, Rapoport, J (1999) Brain development during childhood and adolescence: a longitudinal MRI study. Nature Neurosci 2:861–863.

    Article  PubMed  Google Scholar 

  • Grant K, Valverius P, Hudspith M, Tabakoff B (1990) Alcohol withdrawal seizures and the NMDA receptor complex. Fur J Pharmacol 176:289–296.

    Google Scholar 

  • Hoffman P, Tabakoff B (1994) The role of the NMDA receptor in alcohol withdrawal. EXS 71: 61–70.

    PubMed  Google Scholar 

  • Huttenlocher P (1979) Synaptic density in human frontal cortex — developmental changes and effects of aging. Brain Res 163:195–205.

    Article  PubMed  Google Scholar 

  • Iorio K, Reinlib L, Tabakoff B, Hoffman P (1991) NMDA-induced [Ca2+]i enhanced by chronic alcohol treatment in cultured cerebellar granule cells. Alc Clin Exp Res 15:333.

    Google Scholar 

  • Iorio K, Reinlib L, Tabakoff B, Hoffman P (1992) Chronic exposure of cerebellar granule cells to alcohol results in increased NMDA receptor function. Mol Pharmacol 41:1142–1148.

    PubMed  Google Scholar 

  • Johnston LD, O'Malley PM, Bachman JG (2003) Monitoring the Future national survey results on drug use, 1975–2002. Volume I: Secondary school students (NIH Publication No. 03-5375). Bethesda, MD: National Institute on Drug Abuse, 520 pp.

    Google Scholar 

  • Kapur J, MacDonald R (1996) Pharmacological properties of GABAA receptors from acutely dissociated rat dentate granule cells. Mol Pharmacol 50:458–466.

    PubMed  Google Scholar 

  • Kapur J, MacDonald R (1999) Postnatal development of hippocampal dentate granule cell GABAA receptor pharmacological properties. J Pharmacol Exp Ther 55:444–452.

    Google Scholar 

  • Li Q, Wilson WA, Swartzwelder HS (2002) Differential effect of alcohol on NMDA receptor-mediated EPSCs in pyramidal cells in the posterior cingulate cortex of adolescent and adult rats. J Neurophysiol 87: 705–711.

    PubMed  Google Scholar 

  • Lidow M, Goldman-Rakic P, Rakic P (1991) Synchronized overproduction of neurotransmitter receptors in diverse regions of the primate cerebral cortex. Proc Nat Acad Sci 88:10218–10221.

    PubMed  Google Scholar 

  • Liljequist S, Engel J (1982) Effects of GABAergic agonists and antagonists on various alcohol-induced behavioral changes. Psychopharmacol 78:71–75.

    Article  Google Scholar 

  • Lister RG, Gorenstein C, Fisher-Flowers D, Weingartner HJ, Eckardt MJ (1991) Dissociation of the acute effects of alcohol on implicit and explicit memory processes. Neuropsychologia 29:1205–1212.

    Article  PubMed  Google Scholar 

  • Little HJ (1999) The contribution of electrophysiology to knowledge of the acute and chronic effects of ethanol. Pharmacol Ther 84:333–353.

    Article  PubMed  Google Scholar 

  • Little PJ, Kuhn CM, Wilson WA, Swartzwelder HS (1996) Differential effects of alcohol in adolescent and adult rats. Alc Clin Exp Res 20:1346–1351.

    Article  Google Scholar 

  • Luna B, Thulborn K, Munoz D, Merriam E, Garver K, Minshew N, Keshavan M, Genovese C, Eddy W, Sweeney J (2001) Maturation of widely distributed brain function subserves cognitive development. Neuroimage 13:786–793.

    Article  PubMed  Google Scholar 

  • Markwiese BJ, Acheson SK, Levin ED, Wilson WA, Swartzwelder HS (1998) Differential effects of ethanol on memory in adolescent and adult rats. Alc Clin Exp Res 22:416–421.

    Article  Google Scholar 

  • Martin SJ, Morris RGM (2002) New life in an old idea: The synaptic plasticity and memory hypothesis revisited. Hippocampus 12:609–636.

    Article  PubMed  Google Scholar 

  • Mereu G, Gess G (1985) Low doses of alcohol inhibit the firing of neurons in the substantial nigra, pars reticulara: a GABAergic effect? Brain Res 360:325–330.

    Article  PubMed  Google Scholar 

  • Moy S, Duncan G, Knapp D, Breese G (1998) Sensitivity to alcohol across development in rats: comparison to [3H]zolpidem binding. Alc Clin Exp Res 22:1485 1492.

    Google Scholar 

  • Mueller R-A, Rothermel RD, Behen ME, Muzik O, Mangner TJ, Chugani HT (1998) Developmental changes of cortical and cerebellar motor control: A clinical positron emission tomography study with children and adults. J Child Neurol 13:550–556.

    Article  Google Scholar 

  • Peoples RW, Li C, Weight FF (1996) Lipid vs protein theories of alcohol action in the nervous system. Annu Rev Pharmacol Toxicol 36:185–201.

    Article  PubMed  Google Scholar 

  • Peoples RW, Stewart RR (2000) Alcohols inhibit N-methyl-D-aspartate receptors via a site exposed to the extracellular environment. Neuropharmacology 10:1681–1691.

    Article  Google Scholar 

  • Pyapali G, Turner D, Wilson W, Swartzwelder HS (1999) Age and dose-dependent effects of alcohol on the induction of hippocampal long-term potentiation. Alcohol 19: 107–111.

    Article  PubMed  Google Scholar 

  • Rubia K, Overmeyer S, Taylor E, Brammer M, Williams SC, Simmons A, Andrew C, Bullmore, ET (2000) Functional frontalisation with age: mapping neurodevelopmental trajectories with fMRI. Neurosci Biobehav Rev 24:13–19.

    Article  PubMed  Google Scholar 

  • Ryback RS (1970) Alcohol amnesia: observations in seven drinking inpatient alcoholics. Q J Stud Alcohol 31:616–632.

    PubMed  Google Scholar 

  • Ryback RS (1971) The continuum and specificity of the effects of alcohol on memory. Quart J Stud Alc 32:995–1016.

    Google Scholar 

  • Schummers J, Browning MD (2001) Evidence for a role for GABA(A) and NMDA receptors in ethanol inhibition of long-term potentiation. Brain Research 94:9–14.

    Article  PubMed  Google Scholar 

  • Seeman P (1999) Images in neuroscience. Brain development, X: pruning during development. Am J Psychiatry 156:168.

    PubMed  Google Scholar 

  • Silveri M, Spear L (1998) Decreased sensitivity to hypnotic effects of alcohol early in ontogeny. Alc Clin Exp Res 22:670–676.

    Google Scholar 

  • Smith RF (2003) Animal models of periadolescent substance abuse. Neurotox Teratol 25:291–301.

    Article  Google Scholar 

  • Snell L, Tabakoff B, Hoffman P (1993) Radioligand binding to the NMDA receptor/ionophore complex: Alterations by alcohol invitro and by chronic in-vivo alcohol ingestion. Brain Res 602:91–98.

    Article  PubMed  Google Scholar 

  • Spear L (2000) The adolescent brain and age-related behavioral manifestations. Neurosci Biobehav Rev 24:417–463.

    Article  PubMed  Google Scholar 

  • Spear LP (2002) The adolescent brain and the college drinker: biological basis of propensity to use and misuse alcohol. J Stud Alcohol Suppl (14):71–81

    PubMed  Google Scholar 

  • Swartzwelder HS, Wilson WA, Tayyeb MI (1995a). Differential sensitivity of NMDA receptor-mediated synaptic potentials to alcohol in immature vs. mature hippocampus. Alc Clin. Exp Res 19:320–323.

    Article  Google Scholar 

  • Swartzwelder HS, Wilson WA, Tayyeb MI (1995b). Age-dependent inhibition of long-term potentiation by alcohol in immature vs. mature hippocampus. Alc Clin. Exp Res 19:1480–1485.

    Article  Google Scholar 

  • Swartzwelder HS, Richardson R, Markwiese B, Wilson W, Little P (1998) Developmental differences in the acquisition of tolerance to alcohol. Alcohol 15:311–314.

    Article  PubMed  Google Scholar 

  • Teicher MH, Andersen SL, Hostetter JC (1995) Evidence for dopamine receptor pruning between adolescence and adulthood in striatum but not nucleus accumbens. Dev Brain Res 89:167–172.

    Article  Google Scholar 

  • Weissenborn R, Duka T (2003) Acute alcohol effects on cognitive function in social drinkers: Their relationship to drinking habits. Psychopharmacol 165:306–312.

    Google Scholar 

  • White A, Bae J, Truesdale M, Ahmad S, Wilson W, Swartzwelder HS (2002c) Chronic intermittent alcohol exposure during adolescence prevents normal developmental changes in sensitivity to alcohol-induced motor impairments. Alc Clin Exp Res 26:960–968.

    Article  Google Scholar 

  • White AM, Best PJ (2000) Effects of ethanol on hippocampal place-cell and interneuron activity. Brain Res 876:154–165.

    Article  PubMed  Google Scholar 

  • White, A.M., Ghia, A.J., Levin, E.D. and Swartzwelder, H.S. Binge pattern alcohol exposure: differential impact on subsequent responsiveness to alcohol. Alcoholism: Clin. Exp. Res. 24:1251–1256, 2000.

    Article  Google Scholar 

  • White AM, Jamieson-Drake D, Swartzwelder HS (2002a) Prevalence and correlates of alcohol-induced blackouts among college students: Results of an e-mail survey. J Am College Health 51:117–131.

    Article  Google Scholar 

  • White AM, Matthews DB, Best PJ (2000) Ethanol, memory and hippocampal function: a review of recent findings. Hippocampus 10:88–93.

    Article  PubMed  Google Scholar 

  • White A, Truesdale M, Bae J, Ahmad S, Wilson W, Best P, Swartzwelder HS (2002b) Differential effects of alcohol on motor coordination in adolescent and adult rats. Pharmacol Biochem Behav 73:673–677.

    Article  PubMed  Google Scholar 

  • Xia Y, Haddad G (1992) Ontogeny and distribution of GABAA receptors in rat brainstem and rostral brain regions. Neurosci 49:973–989.

    Article  Google Scholar 

  • Zhang L, Spigelman I, Carlen P (1991) Development of GABA mediated, chloride dependent inhibition in CA1 pyramidal neurons of immature rat hippocampal slices. J Physiol 444: 25–49.

    PubMed  Google Scholar 

  • Zola-Morgan S, Squire LR, Amaral DG (1986). Human amnesia and the medial temporal lobe region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus. J Neurosci 16:2950–2967.

    Google Scholar 

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Authors and Affiliations

  1. Neurobiology Research Labs, Veterans Affairs Medical Center, Duke University Medical Center, Durham, North Carolina, 27710

    Aaron M. White & H. Scott Swartzwelder

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  1. Aaron M. White
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  2. H. Scott Swartzwelder
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Editors and Affiliations

  1. New York University School of Medicine, New York, New York

    Marc Galanter

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© 2005 Kluwer Academic/Plenum Publishers

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White, A.M., Scott Swartzwelder, H. (2005). Age-Related Effects of Alcohol on Memory and Memory-Related Brain Function in Adolescents and Adults. In: Galanter, M., Lowman, C., Boyd, G.M., Faden, V.B., Witt, E., Lagressa, D. (eds) Recent Developments in Alcoholism. Recent Developments in Alcoholism, vol 17. Springer, Boston, MA. https://doi.org/10.1007/0-306-48626-1_8

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