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Wnt Signaling in Human Cancer

  • Chapter
Signal Transduction in Cancer

Part of the book series: Cancer Treatment and Research ((CTAR,volume 115))

Conclusions

Activation of the Wnt pathway can proceed through at least three downstream signaling cascades mediating various cellular effects. We have described several findings that suggest important roles for the Wnt pathway in the development of human cancer. This role is not completely surprising considering the critical importance of this pathway in directing cell proliferation, migration and differentiation during vertebrate embryonic development.

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Authors and Affiliations

  1. Laboratory of Cellular and Molecular Biology, National Institute on Aging, NIH, 5600 Nathan Shock Drive, Baltimore, MD, 21224

    Patrice J. Morin

  2. Ashani Genetics Branch, National Human Genome Research Institute, NIH, 49 Convent Drive, Bethesda, MD, 20892

    Ashani T. Weeraratna

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  1. Patrice J. Morin
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  1. Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA

    David A. Frank MD, PhD

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Morin, P.J., Weeraratna, A.T. (2004). Wnt Signaling in Human Cancer. In: Frank, D.A. (eds) Signal Transduction in Cancer. Cancer Treatment and Research, vol 115. Springer, Boston, MA. https://doi.org/10.1007/0-306-48158-8_7

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  • DOI: https://doi.org/10.1007/0-306-48158-8_7

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