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PI3K/PTEN/Akt Pathway

A critical mediator of oncogenic signaling

  • Chapter
Signal Transduction in Cancer

Part of the book series: Cancer Treatment and Research ((CTAR,volume 115))

Conclusion

In conclusion, direct genetic alterations leading to deregulated PI3K/Akt signalling are common in a significant fraction of human malignancies. The forthcoming decade should witness the development and clinical deployment of a number of novel small molecule inhibitors specifically designed to disrupt the function of members of this pathway. It is hoped and perhaps likely that such inhibitors, either alone or in combination with current therapeutics, will ultimately proof clinically efficacious.

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  1. Department of Adult Oncology Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02115

    Juan Paez & William R. Sellers

  2. Department of Medicine Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02115

    Juan Paez & William R. Sellers

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  1. Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA

    David A. Frank MD, PhD

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Paez, J., Sellers, W.R. (2004). PI3K/PTEN/Akt Pathway. In: Frank, D.A. (eds) Signal Transduction in Cancer. Cancer Treatment and Research, vol 115. Springer, Boston, MA. https://doi.org/10.1007/0-306-48158-8_6

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