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The Roles of Map Kinases in Controling Cancer Metastasis

  • Chapter
Cancer Metastasis — Related Genes

Part of the book series: Cancer Metastasis — Biology and Treatment ((CMBT,volume 3))

Concluding Remarks

The MAP kinases have been implicated in cell growth and differentiation. Dysregulation of these pathways results in the increased incidence of tumorgenicity and metastasis. The mechanisms by which these pathways lead to cancer have yet to be elucidated. Recently, Taguchi et al. have shown that blocking the interaction of the receptor for advanced glycation end products (RAGE) and its ligand, amphoterin by various strategies, such as the administration of the soluble, extracellular region of RAGE, resulted in the reduction of tumour volume and metastases in mice (95). interestingly, the inhibition of RAGE-amphoterin interaction resulted in decreased ERK1/2, SAPK, and p38 MAP kinase activities, and reduced expression of MMP-2 and MMP-9 (95).

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  1. Medical Services, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Massachasetts, USA

    Alessandro Alessandrini

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  1. Jake Gittlen Cancer Research Institute, The Pennsylvania State University College of Medicine, Pennsylvania, USA

    Danny R. Welch

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Alessandrini, A. (2002). The Roles of Map Kinases in Controling Cancer Metastasis. In: Welch, D.R. (eds) Cancer Metastasis — Related Genes. Cancer Metastasis — Biology and Treatment, vol 3. Springer, Dordrecht. https://doi.org/10.1007/0-306-47821-8_2

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  • DOI: https://doi.org/10.1007/0-306-47821-8_2

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