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Rox1 Medited Repression

Oxygen dependent repression in yeast

  • Chapter
Oxygen Sensing

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 475))

Abstract

For a large number of oxygen-regulated genes in the facultative aerobe, Saccharomyces cerevisiae, the presence of oxygen is sensed through the ability to use oxygen for heme biosynthesis. Heme induces the transcription of oxygen-induced genes and represses the transcription of hypoxic genes. Repression is mediated by the Rox1 protein in conjunction with the Ssn6/Tupl general repression complex. The differential repression of hypoxic genes results from a combination of the tightness of Rox1 binding to the regulatory region of specific hypoxic genes and the presence or absence of binding sites for Mot3 which enhances Rox1 repression.

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Authors and Affiliations

  1. Dept. Biol. Sci., University at Albany, SUNY, Albany, USA

    Alexander J. Kastaniotis & Richard S. Zitomer

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  1. Alexander J. Kastaniotis
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  2. Richard S. Zitomer
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Editors and Affiliations

  1. University of Pennsylvania Medical Center, Philadelphia, Pennsylvania

    Sukhamay Lahiri  & Robert E. Forster II  & 

  2. Case Western Reserve University, Cleveland, Ohio

    Naduri R. Prabhakar

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© 2002 Kluwer Academic Publishers

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Kastaniotis, A.J., Zitomer, R.S. (2002). Rox1 Medited Repression. In: Lahiri, S., Prabhakar, N.R., Forster, R.E. (eds) Oxygen Sensing. Advances in Experimental Medicine and Biology, vol 475. Springer, Boston, MA. https://doi.org/10.1007/0-306-46825-5_18

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  • DOI: https://doi.org/10.1007/0-306-46825-5_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46367-9

  • Online ISBN: 978-0-306-46825-4

  • eBook Packages: Springer Book Archive

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