Abstract
The expression of several oxygen-regulated nuclear genes in the yeast Saccharomyces cerevisiae is affected by the mitochondrion. Recent evidence suggests two levels of mitochondrial involvement. On the one hand, mitochondrial respiratory function is essential for the anoxic induction of some hypoxic genes. On the other hand, the mitochondrial genome itself functions independently of its respiratory function, in the optimal expression of some aerobic genes. These findings suggest that the mitochondrion release at least two types of ‘signals’ that function in the expression of oxygen-regulated genes.
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© 2002 Kluwer Academic Publishers
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Poyton, R.O., Dagsgaard, C.J. (2002). Mitochondrial-Nuclear Crosstalk is Involved in Oxygen-Regulated Gene Expression in Yeast. In: Lahiri, S., Prabhakar, N.R., Forster, R.E. (eds) Oxygen Sensing. Advances in Experimental Medicine and Biology, vol 475. Springer, Boston, MA. https://doi.org/10.1007/0-306-46825-5_17
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DOI: https://doi.org/10.1007/0-306-46825-5_17
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