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Possible Involvement of Cytoskeletal Components in the Control of Hepatic Carnitine Palmitoyltransferase I Activity

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Current Views of Fatty Acid Oxidation and Ketogenesis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 466))

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References

  1. McGarry, J.D., Woeltje, K.F., Kuwajima, M. & Foster, D.W. (1989) Diabetes Metab. Rev. 5, 271–284. Regulation of ketogenesis and the renaissance of carnitine palmitoyltransferase.

    CAS  PubMed  Google Scholar 

  2. Zammit, V.A. (1994) Diabetes Rev. 2, 132–155. Regulation of ketone body metabolism. A cellular perspective.

    Google Scholar 

  3. Guzmán, M. & Geelen, M.J.H. (1993) Biochim. Biophys. Acta 1167, 227–241. Regulation of fatty acid oxidation in mammalian liver.

    PubMed  Google Scholar 

  4. Eaton, S., Bartlett, K. & Pourfarzam, M. (1996) Biochem. J. 320, 345–357. Mammalian mitochondrial β-oxidation.

    CAS  PubMed  Google Scholar 

  5. McGarry, J.D. & Brown, N.F. (1997) Eur. J. Biochem. 244, 1–14. The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis.

    Article  CAS  PubMed  Google Scholar 

  6. Drynan, L., Quant, P.A. & Zammit, V.A. (1996) Biochem. J. 317, 791–795. Flux control exerted by mitochondrial outer membrane carnitine palmitoyltransferase over β-oxidation, ketogenesis and tricarboxylic acid cycle activity in hepatocytes isolated from rats in different metabolic states.

    CAS  PubMed  Google Scholar 

  7. Spurway, T., Sherrat, H.S.A., Pogson, C.I. & Agius, L. (1997) Biochem. J. 323, 119–122. The flux control coefficient of carnitine palmitoyltransferase I on palmitate β-oxidation in rat hepatocyte cultures.

    CAS  PubMed  Google Scholar 

  8. McGarry, J.D. & Foster, D.W. (1980) Annu. Rev. Biochem. 49, 395–420. Regulation of hepatic fatty acid oxidation and ketone body production.

    Article  CAS  PubMed  Google Scholar 

  9. Guzmán, M. & Geelen, M.J.H. (1992) Biochem. J. 287, 487–492. Activity of carnitne palmitoyltransferase in mitochondrial outer membranes and peroxisomes in digitonin-permeabilized hepatocytes. Selective modulation of mitochondrial enzyme activity by okadaic acid.

    PubMed  Google Scholar 

  10. Guzman, M., Kolodziej, M.P., Caldwell, A., Costorphine, C.G. & Zammit, V.A. (1994) Biochem. J. 300, 693–699. Evidence against direct involvement of phosphorylation in the activation of carnitine palmitoyltransferase by okadaic acid in rat hepatocytes.

    CAS  PubMed  Google Scholar 

  11. Velasco, G., Guzmán, M., Zammit, V.A. & Geelen, M.J.H. (1997) Biochem. J. 321, 211–216. Involvement of Ca2+/calmodulin-dependent protein kinase II in the activation of carnitine palmitoyltransferase I by okadaic acid in rat hepatocytes.

    CAS  PubMed  Google Scholar 

  12. Velasco, G., Sánchez, C., Geelen, M.J.H. & Guzmán, M. (1996) Biochem. Biophys. Res. Commun. 224, 754–759. Are cytoskeletal components involved in the control of hepatic carnitine palmitoyltransferase I activity?

    Article  CAS  PubMed  Google Scholar 

  13. Braun, A.P. & Schulman, H. (1995) Annu. Rev. Physiol. 57, 417–445. The multifunctional calcium/calmodulin-dependent protein kinase: from form to function.

    Article  CAS  PubMed  Google Scholar 

  14. Bereiter-Hahn, J. & Vöth, M. (1994) Microsc. Res. Tech. 27, 198–219. Dynamics of mitochondria in living cells: shape changes, dislocations, fusion, and fission of mitochondria.

    Article  CAS  PubMed  Google Scholar 

  15. Leterrier, J.F., Rusakov, D.A., Nelson, B.D. & Lindén, M. (1994) Microsc. Res. Tech. 27, 233–261. Interactions between brain mitochondria and cytoskeleton: evidence for specialized outer membrane domains involved in the association of cytoskeleton-associated proteins to mitochondria in situ and in vivo.

    Article  CAS  PubMed  Google Scholar 

  16. Holen, I., Gordon, P.B. & Seglen, P.O. (1992) Biochem. J. 284, 633–636. Protein kinase-dependent effects of okadaic acid on hepatocytic autophagy and cytoskeletal integrity.

    CAS  PubMed  Google Scholar 

  17. Lindén, M. & Karlsson, G. (1996) Biochem. Biophys. Res. Commun. 218, 833–836. Identification of porin as a binding site for MAP2.

    PubMed  Google Scholar 

  18. Collier, N.C., Sheetz, M.P. & Schlesinger, M.J. (1993) J. Cell Biochem. 52, 297–397. Concomitant changes in mitochondria and intermediate filaments during heat shock and recovery of chicken embryo fibroblasts.

    Article  CAS  PubMed  Google Scholar 

  19. Fuchs E. & Cleveland D.W. (1998) Science 279, 514–519. A structural scaffolding of intermediate filaments in health and disease.

    Article  CAS  PubMed  Google Scholar 

  20. Omary, M.B. & Ku, N.O. (1997) Hepatology 25, 1043–1048. Intermediate filament proteins of the liver: emerging disease association and functions.

    Article  CAS  PubMed  Google Scholar 

  21. Paumen, M.P., Ishida, Y., Muramatsu, M., Yamamoto, M. & Honjo, T. (1997) J. Biol. Chem. 272. 3324–3329. Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis.

    CAS  PubMed  Google Scholar 

  22. Velasco, G., Passilly, P., Guzmán, M. & Latruffe, N. (1998) Biochem. Pharmacol. (in press). Loss of response of carnitine palmitoyltransferase I to okadaic acid in transformed hepatic cells.

    Google Scholar 

  23. Toivola, D.M., Goldman, R.D., Garrod, D.R. & Eriksson, J.E. (1997) J. Cell Sci. 110, 23–33. Protein phosphatases maintain the organization and structural interactions of hepatic keratin intermediate filaments.

    CAS  PubMed  Google Scholar 

  24. Inagaky, M., Inagaki, N., Takahashi, T. & Takay, Y. (1997) J. Biochem. (Tokyo) 121, 407–414. Phosphorylation-dependent control of structures of intermediate filaments: a novel approach using site-and phosphorylation state-specific antibodies.

    Google Scholar 

  25. Ku, N.O. & Omary, B. (1994) J. Cell Biol. 127, 161–171. Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization.

    Article  CAS  PubMed  Google Scholar 

  26. Cadrin, M., McFarlane-Anderson, N., Aasheim, L.H., Kawahara, H., Franks, D.J., Marceau, N. & French, S.W. (1992) Cell. Signal. 4, 715–722. Differential phosphorylation of CK8 and CKI8 by 12-O-tetradecanoyl-phorbol-13-acetate in primary cultures of mouse hepatocytes.

    Article  CAS  PubMed  Google Scholar 

  27. McGarry, J.D., Mannaerts, G.P. & Foster, D.W. (1977) J. Clin. Invest. 60, 265–270. A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis.

    CAS  PubMed  Google Scholar 

  28. Velasco, G., Geelen, M.J.H. & Guzmán, M. (1997) Arch. Biochem. Biophys. 337, 169–175. Control of hepatic fatty acid oxidation by 5’-AMP-activated protein kinase involves a malonyl-CoA-dependent and a malonyl-CoA-independent mechanism.

    Article  CAS  PubMed  Google Scholar 

  29. Geelen. M.J.H., Bijleveld, C., Velasco, G., Wanders, R.A.J. & Guzmán, M. (1997) Biochem. Biophys. Res. Commun. 233, 253–257. Studies on the intracellular localization of acetyl-CoA carboxylase.

    Article  CAS  PubMed  Google Scholar 

  30. Ha, J., Lee, J.K., Kirn, K.S., Witters, L.A. & Kim, K.H. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 11466–1147031. Cloning of human acetyl-CoA carboxylase-β and its unique features.

    CAS  PubMed  Google Scholar 

  31. Fraser, F., Costorphine, C.G. & Zammit, V.A. (1997) Biochem. J. 323, 711–718. Topology of carnitine palmitoyltransferase I in the mitochondrial outer membrane.

    CAS  PubMed  Google Scholar 

  32. Forgacs, G. (1995) J. Cell Sci. 108, 2131–2143. On the possible role of cytoskeletal filamentous networks in intracellular signaling: an approach based on percolation.

    CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology I School of Biology, Complutense University, 28040, Madrid, Spain

    Guillermo Velasco, Teresa Gómez del Pulgar & Manuel Guzmán

  2. Laboratory of Veterinary Biochemistry and Institute of Biomembranes, Utrecht University, P.O. Box 80.176, 3508-TD, Utrecht, The Netherlands

    Math J. H. Geelen

Authors
  1. Guillermo Velasco
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  2. Math J. H. Geelen
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  3. Teresa Gómez del Pulgar
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  4. Manuel Guzmán
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Editor information

Editors and Affiliations

  1. Unit of Paediatric Surgery Institute of Child Health & Great Ormond Street Hospital for Children NHS Trust, University College London Medical School, London, UK

    Patti A. Quant  & Simon Eaton  & 

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© 2002 Kluwer Academic Publishers

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Velasco, G., Geelen, M.J.H., del Pulgar, T.G., Guzmán, M. (2002). Possible Involvement of Cytoskeletal Components in the Control of Hepatic Carnitine Palmitoyltransferase I Activity. In: Quant, P.A., Eaton, S. (eds) Current Views of Fatty Acid Oxidation and Ketogenesis. Advances in Experimental Medicine and Biology, vol 466. Springer, Boston, MA. https://doi.org/10.1007/0-306-46818-2_4

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  • DOI: https://doi.org/10.1007/0-306-46818-2_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46200-9

  • Online ISBN: 978-0-306-46818-6

  • eBook Packages: Springer Book Archive

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