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Adenovirus-Mediated Herpes Simplex Thymidine Kinase Gene Therapy For Brain Tumors

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Cancer Gene Therapy

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 465))

Conclusions

Adenovirus-mediated HSVtk gene therapy has been shown to be eefective for the treatment of malignant glioma when the gene transfer efficiency is high. Adenoviruses are currently the most promising vectors for gene therapy of malignant glioma especially because of their high efficiency of gene transfer. Experiences from preclinical in vitro and in vivo studies are promising and in the near future the first reports of clinical phase I and II studies should be available. These results will significantly advance our understanding about the efficacy of adenovirus-mediated gene transfers in the treament of malignant glioma in man.

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References

  • Ammirati, M., Galicich, J.H., Arbit, E., and Liao, Y. 1987, Reoperation in the treatment of recurrent intracranial malignant gliomas. Neurosurgery 21:607–614.

    Article  CAS  Google Scholar 

  • Bi, W.L., Parysek, L.M., Warnick, R., and Stambrook, P.J., 1993, In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSVtk retroviral gene therapy. Hum. Gene Ther. 4:725–731.

    Article  CAS  Google Scholar 

  • Boviatsis, E.J., Chase, M., Wei, MX., Tamiya, T., Hurford, R.K.Jr., Kowall, N.W., Tepper, R.I., Breakefield, X.O., and Chiocca, E.A. 1994, Gene transfer into experimental brain tumors mediated by adenovirus, Herpes simplex virus, and retrovirus vectors. Hum Gene Ther 5:183–191.

    Article  CAS  Google Scholar 

  • Chen, S.-H., Shine, H.D., Goodman, J.C., Grossman, R.G., and Woo, S.L.C. 1994, Gene therapy for brain tumors: Regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. Proc Natl Acad Sci USA 91:3054–3057.

    Article  CAS  Google Scholar 

  • Colak, A., Goodman, J.C., Chen, S.H., Woo, S.L.C., Grossman, R.G., and Shine, H.D., 1995, Adenovirus-mediated gene therapy for experimental spinal cord tumors: tumoricidal efficacy and functional outcome. Brain Research. 691:76–82.

    Article  CAS  Google Scholar 

  • Davies, E., Clarke, C., and Hopkins, A., 1996, Malignant cerebral glioma-1: Survival, disability, and morbidity after radiotherapy. BMJ, 313:1507–1512.

    Article  CAS  Google Scholar 

  • Dietrich, P.Y., Walker, P.R., Saas, P., and de Tribolet, N., 1997, Immunobiology of Gliomas: New Perspectives for Therapy, Ann NY Acad Sci 824:124–140.

    Article  CAS  Google Scholar 

  • Fuller, G.N., and Burger, P.C., 1996, Gliomas: Pathology, in: Neurosurgery. Volume 1 (Wilkins, R.H., and Rengachary, S.S., eds). pp. 735–747, McGrawn-Hill, Health professions Division.

    Google Scholar 

  • Hildebrandt, J., Dewitte, O., Dietrich, P.Y., and de Tribolet, N., 1997, Eur Neurol, 38:238–253.

    Article  Google Scholar 

  • Kajiwara, K., Byrnes, A.P., Charlton, H.M., Wood, M.J.A., and Wood, K.J., 1997, Immune Responses to Adenoviral Vectors During Gene Transfer in the Brain. Hum. Gene Ther. 8:253–265.

    Article  CAS  Google Scholar 

  • Kaneko, Y., Kitamoto, T., Tateishi, J., and Yamaguchi, K. 1989, Ferritin immunohistochemistry as a marker for microglia. Acta Neuropathol, 79:129–136.

    Article  CAS  Google Scholar 

  • Kernohan, J.W., Mabon, R.F., Svien, H.J., and Adson, A.W., 1949, A simplified classification of the gliomas. Proc Staff Mtg Mayo Clin, 24:71–75.

    CAS  Google Scholar 

  • Kleilhues, P., Burger, P.C., and Scheithauer, B.W., 1993, The new WHO classification of brain tumours. Brain Pathol, 3:255–268.

    Article  Google Scholar 

  • Laitinen, M., Mäkinen, K., Manninen, H., Matsi, P., Kossila, M., Agrawal, R.S., Pakkanen, T., Luoma, J.S., Viita, H., Hartikainen, J., Alhava, E., Laakso, M., and Ylä-Herttuala, S., 1998, Adenovirus-mediated gene transfer to lower limb artery of patients with chronic critical leg ischaemia. Hum Gene Ther, 9:1481–1486.

    Article  CAS  Google Scholar 

  • Le Gal La Salle, G., Robert, J.J., Berrard, V, Ridoux. L.D., Stratford-Perricaudet, L.D., Perricaudet, M., and Mallet, J., 1993, An adenovirus vector for gene transfer into neurons and glia in the brain. Science 259:988–990.

    Article  Google Scholar 

  • Leibel, S.A., Gutin, P.H., Wara, W.M., Silver, P.S., Larson, D.A., Edwards, M.S., Lamb, S.A., Ham. B., Weaver, K.A., and Barnett, C., 1989, Survival and quality of life after interstitial implantation of removable high-activity iodine-125 sources for the treatment of patients with recurrent malignant gliomas. Int J Radiat Oncol Biol Phys, 17:1129–1139.

    Article  CAS  Google Scholar 

  • Levy, M.L., and Apuzzo, M.L.J., Immunobiolgy of Brain Tumors, in: Neurosurgery, Volume 1 (Wilkins, R.H., and Rengachary, S.S., eds), pp. 707–713, McGrawn-Hill, Health professions Division.

    Google Scholar 

  • Maron, A., Havaux, N., Le Roux, A., Knoops, B., Perricaudet, M., and Octave, J.N., 1997, Differential toxicity of ganciclovir for rat neurons and astrocytes in primary culture following adenovirus-mediated transfer of the HSVtk gene. Gene Ther. 4:25–31.

    Article  CAS  Google Scholar 

  • Maron, A., Le Roux, A.L., Mottet, I., Dedieu, J.F., Brion, J.P., Demeure, R., Perricaudet, M., and Octave, J.N., 1996, Gene therapy of rat C6 glioma using adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene: long-term follow-up by magnetic resonance imaging. Gene Therapy. 3:315–322.

    PubMed  CAS  Google Scholar 

  • Moolten, F.L., 1994, Drug sensitivity (“suicide”) genes for selective cancer chemotherapy. Cancer Gene Ther, 1:279–287.

    PubMed  CAS  Google Scholar 

  • Perez-Cruet, M.J., Trask, T.W., Chen, S.H., Goodman, J.C., Woo, S.L.C., Grossman, R.G., and Shine, H.D., 1994, Adenovirus-Mediated Gene Therapy of Experimental Gliomas. Journal of Neuroscience Research. 39:506–511.

    Article  CAS  Google Scholar 

  • Puumalainen, A.M., Puranen, P., Loimas, S., Puranen, M., Hurskainen, H., Kossila, M., Tyynelä, K., Turunen, M., Vanninen, R., Lehtolainen, P., Paljärvi, L., Johansson, R., Vapalahti, M., and Ylä-Herttuala, S. Thymidine kinase gene therapy for human malignant glioma using replication-deficient retroviruses or adenoviruses. Phase I safety and efficacy trial. Submitted.

    Google Scholar 

  • Puumalainen, A.M., Turunen, M., Loimas, S., Vainio, P., Tyynelä, K.., Vanninen, R., Vapalahti, M., Bjerkvig, R., Jänne, J., and Ylä-Herttuala, S., Herpes Simplex virus thymidine kinase gene therapy in experimental rat BT4C glioma model. Submitted.

    Google Scholar 

  • Puumalainen, A.M., Vapalahti, M., Agrawal, R., Kossila, M., Laukkanen, M., Lehtolainen, P., Viita, H., Paljärvi, L., Vanninen, R., and Ylä-Herttuala, S., 1998, B-galactosidase gene transfer to human malignant glioma in vivo using replication-deficientretroviruses and adenoviruses. Hum. Gene Ther. 9:1769–1774.

    Article  CAS  Google Scholar 

  • Ram, Z., Culver, K.W., Oshiro, E.M., Viola, J.J., DeVroom, H.L., Otto, E., Long, Z., Chiang, Y., McCarrity, G.J., Muul, L.M., Katz, D., Blaese, M., and Oldfield, E.H., 1997, Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells. Nature Medicine 3:1354–1361.

    Article  CAS  Google Scholar 

  • Salcman, M., 1980, Survival in glioblastoma. Historical prespective. Neurosurgery, 7:435–439.

    Article  CAS  Google Scholar 

  • Salcman, M., 1996, Supratentorial Gliomas: Clinical Features and Surgical Therapy, in: Neurosurgery, Volume 1 (Wilkins, R.H., and Rengachary, S.S., eds), pp. 777–788, McGrawn-Hill, Health professions Division.

    Google Scholar 

  • Tyynelä, K., Puumalainen, A.M., Turunen, M., Hakumäki, J., Kauppinen, R., Johansson, R., and Ylä-Herttuala, S., 1998, Adenovirus-mediated Herpes simplex virus-thymidine kinase gene therapy in BT4C rat glioma in vivo. Submitted.

    Google Scholar 

  • Vincent, A.J.P.E., Esandi, M.C., Avezaat, C.J.J., Vecht, C, Smitt, P.S., Bekkum, D.W., Valerio, D., Hoogerbrugge, P.M., and Bout, A., 1997, Preclinical Testing of Recombinant Adenoviral Herpes Simplex Virus-Thymidine Kinase Gene Therapy for Central Nervous System Malignancies. Neurosurgery. 41:442–452.

    Article  CAS  Google Scholar 

  • Vincent, A.J.P.E., Esandi, M.C., Someren, G., Notebloom, J.L., Avezaat, C.J.J., Vecht, C., Smitt, P.A.E.S., Bekkum, D.W., Valerio, D., Hoogerbrugge, P.M., and Bout, A., 1996, Treatment of leptomeningeal metastases in a rat model using a recombinant adenovirus containing the HSV-tk gene. J Neurosurg. 85:648–654.

    Article  CAS  Google Scholar 

  • Vincent, A.J.P.E., Vogels, R., Someren, G.V., Esandi, M.C., Notebloom, J.L., Avezaat, C.J.J., Vecht, C., Bekkum, D.W.V., Valerio, D., Bout, A., and Hoogerbrugge, P.M., 1996, Herpes Simplex Virus Thymidine Kinase Gene Therapy for Rat Malignant Brain Tumors. Human Gene Therapy. 7:197–205.

    Article  CAS  Google Scholar 

  • Viola, J.J., Ram, Z., Walbridge, S., Oshiro, E.M., Trapnell, B., Tao-Cheng, J.H., and Oldfield, E.H., Adenovirally mediated gene transfer into experimental solid brain tumors and leptomeningeal cancer cells. J Neurosurg 82:pp70–76.

    Google Scholar 

  • Walker, M.D., Alexander, E., Hunt, W.E., MacCarty, C.S., Mahaley, J., and Norell, H.A., et al., 1978, J Neurosurg, 49:333–343.

    Article  CAS  Google Scholar 

  • Walker, M.D., Green, S.B., Byar, D.P., Alexander, E., Batzdorf, U., Brooks, W.H., Hunt, WE., MacCarty, C.S., Mahaley, M.S., Mealey, J., Owens, G., Ransohoff, J., Robertson, J.T., Saphiro, W.R., Smith, K.R. Jr., Wilson, C.B., and Strike, T.A., 1980, Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. N Engl J Med, 303:1323–1329.

    Article  CAS  Google Scholar 

  • Watkins, D., and Rouleau, G.A., 1994, Genetics, Prognosis and Therapy of Central Nervous System Tumors. Cancer Detection and Prevention, 18:139–144.

    PubMed  CAS  Google Scholar 

  • Wilson, J., 1995, Adenoviruses as Gene-Delivery Vehicles. N Engl J Med 334:1185–1187.

    Article  Google Scholar 

  • Ylä-Herttuala, S., 1998, Gene therapy for cancer. In: Tumor Invasion: Biological, Clinical and Therapeutical Considerations. (Mikkelsen, Bjerkvig, Laerum, Rosenblum eds), pp. 435–445, John Wiley & Sons.

    Google Scholar 

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Author information

Authors and Affiliations

  1. A.I. Virtanen Institute, University of Kuopio, P.O.B. 1627, FIN-70211, Kuopio, Finland

    Anu-Maaria Sandmair & Seppo Ylä-Herttuala

  2. Department of Neurosurgery, University Hospital of Kuopio, P.O.B. 1777, FIN-70110, Kuopio, Finland

    Anu-Maaria Sandmair & Matti Vapalahti

  3. Gene Therapy Unit, University Hospital of Kuopio, P.O.B. 1777, FIN-70110, Kuopio, Finland

    Matti Vapalahti & Seppo Ylä-Herttuala

  4. Department of Medicine, University Hospital of Kuopio, P.O.B. 1777, FIN-70110, Kuopio, Finland

    Seppo Ylä-Herttuala

Authors
  1. Anu-Maaria Sandmair
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  2. Matti Vapalahti
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  3. Seppo Ylä-Herttuala
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Editor information

Editors and Affiliations

  1. Imperial College School of Medicine, Hammersmith Hospital, London, UK

    Nagy A. Habib

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© 2002 Kluwer Academic Publishers

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Sandmair, AM., Vapalahti, M., Ylä-Herttuala, S. (2002). Adenovirus-Mediated Herpes Simplex Thymidine Kinase Gene Therapy For Brain Tumors. In: Habib, N.A. (eds) Cancer Gene Therapy. Advances in Experimental Medicine and Biology, vol 465. Springer, New York, NY. https://doi.org/10.1007/0-306-46817-4_15

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  • DOI: https://doi.org/10.1007/0-306-46817-4_15

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-306-46191-0

  • Online ISBN: 978-0-306-46817-9

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