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Biomedical Photonics for Intraoperative Diagnostics: Review of Capabilities and Clinical Applications

  • Published:
Moscow University Physics Bulletin Aims and scope

Abstract

Optical spectroscopy and microscopy techniques are widely used for basic studies of living systems. However, their application in clinical practice has two fundamental limitations. First, the depth of probing biological tissues with light is small and varies from tenths to several of millimeters. Secondly, it is difficult to use exogenous labels, which increase the sensitivity and specificity of pathological tissue detection, in vivo measurements on patients. This raises the question of the place of biomedical photonics among other physical diagnostic methods used in clinical practice. This article presents an review of optical methods and relatively new certified commercially available medical devices that use photonics to solve intraoperative diagnostic problems, i.e., the discrimination between pathological and healthy tissue sites in vivo and ex vivo by an endogenous optical response. This work discusses a wide range of medical fields in which researchers and engineers have been able to achieve high rates of sensitivity and specificity in solving the problem of classifying such tissues. The advantages and disadvantages of optical imaging and diagnostic methods, which determine their place in clinical practice, are discussed by the example of intraoperative diagnostics.

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Funding

This work was carried out within the program of the development of the Interdisciplinary Scientific and Educational School of the Lomonosov Moscow State University ‘‘Photonic and Quantum Technologies. Digital Medicine.’’

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Authors and Affiliations

  1. Department of Physics, Lomonosov Moscow State University, Moscow, 119991, Russia

    E. A. Shirshin, B. P. Yakimov, N. V. Zlobina, D. A. Davydov, V. V. Fadeev & N. N Sysoev

  2. Medical Research and Educational Center, LomonosovMoscow State University, Moscow, 119192, Russia

    E. A. Shirshin, B. P. Yakimov, G. S. Budylin, N. V. Zlobina, D. A. Davydov, A. G. Armaganov & A. A. Kamalov

  3. Institute of Spectroscopy, Russia Academy of Sciences, Moscow, 108840, Russia

    G. S. Budylin

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Correspondence to E. A. Shirshin, B. P. Yakimov, N. V. Zlobina, D. A. Davydov, A. G. Armaganov, V. V. Fadeev, N. N Sysoev or A. A. Kamalov.

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Shirshin, E.A., Yakimov, B.P., Budylin, G.S. et al. Biomedical Photonics for Intraoperative Diagnostics: Review of Capabilities and Clinical Applications. Moscow Univ. Phys. 77, 777–800 (2022). https://doi.org/10.3103/S002713492206011X

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